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Single-crystal to single-crystal conformational polymorphic transformation in tolbutamide at 313 K. Relation to other polymorphic transformations in tolbutamide and chlorpropamide. / Drebushchak, T. N.; Drebushchak, V. A.; Pankrushina, N. A. et al.

In: CrystEngComm, Vol. 18, No. 30, 2016, p. 5736-5743.

Research output: Contribution to journal › Article › peer-review

Harvard

Drebushchak, TN, Drebushchak, VA, Pankrushina, NA & Boldyreva, EV 2016, 'Single-crystal to single-crystal conformational polymorphic transformation in tolbutamide at 313 K. Relation to other polymorphic transformations in tolbutamide and chlorpropamide', CrystEngComm, vol. 18, no. 30, pp. 5736-5743. https://doi.org/10.1039/c6ce00764c

APA

Drebushchak, T. N., Drebushchak, V. A., Pankrushina, N. A., & Boldyreva, E. V. (2016). Single-crystal to single-crystal conformational polymorphic transformation in tolbutamide at 313 K. Relation to other polymorphic transformations in tolbutamide and chlorpropamide. CrystEngComm, 18(30), 5736-5743. https://doi.org/10.1039/c6ce00764c

Vancouver

Drebushchak TN, Drebushchak VA, Pankrushina NA, Boldyreva EV. Single-crystal to single-crystal conformational polymorphic transformation in tolbutamide at 313 K. Relation to other polymorphic transformations in tolbutamide and chlorpropamide. CrystEngComm. 2016;18(30):5736-5743. doi: 10.1039/c6ce00764c

Author

Drebushchak, T. N. ; Drebushchak, V. A. ; Pankrushina, N. A. et al. / Single-crystal to single-crystal conformational polymorphic transformation in tolbutamide at 313 K. Relation to other polymorphic transformations in tolbutamide and chlorpropamide. In: CrystEngComm. 2016 ; Vol. 18, No. 30. pp. 5736-5743.

BibTeX

@article{a3265802eb7842f384afd258dee67926,
title = "Single-crystal to single-crystal conformational polymorphic transformation in tolbutamide at 313 K. Relation to other polymorphic transformations in tolbutamide and chlorpropamide",
abstract = "Three polymorphs of tolbutamide (IL, II, and III) were studied using single-crystal X-ray diffraction, from 100 K to room temperature (forms II and III) and to 350 K (form I), and differential scanning calorimetry. The reversible transformation, IL IH, was found to be of the single-crystal to single-crystal type and the structure of the high-temperature form (IH) was solved and refined. The structure of IH differs from that of IL only in the conformation of the molecule, with molecular arrangements being practically unchanged (isostructural conformational transformation). The transition takes place at 313 K with no sign of hysteresis. The volume change, ΔV/V, across the reversible transformation IL IH was calculated and compared to those for the other conformational transformations. Two types of conformational polymorphic transformations (irreversible reconstructive and reversible isostructural) in tolbutamide and chlorpropamide were compared.",
author = "Drebushchak, {T. N.} and Drebushchak, {V. A.} and Pankrushina, {N. A.} and Boldyreva, {E. V.}",
year = "2016",
doi = "10.1039/c6ce00764c",
language = "English",
volume = "18",
pages = "5736--5743",
journal = "CrystEngComm",
issn = "1466-8033",
publisher = "Royal Society of Chemistry",
number = "30",

}

RIS

TY - JOUR

T1 - Single-crystal to single-crystal conformational polymorphic transformation in tolbutamide at 313 K. Relation to other polymorphic transformations in tolbutamide and chlorpropamide

AU - Drebushchak, T. N.

AU - Drebushchak, V. A.

AU - Pankrushina, N. A.

AU - Boldyreva, E. V.

PY - 2016

Y1 - 2016

N2 - Three polymorphs of tolbutamide (IL, II, and III) were studied using single-crystal X-ray diffraction, from 100 K to room temperature (forms II and III) and to 350 K (form I), and differential scanning calorimetry. The reversible transformation, IL IH, was found to be of the single-crystal to single-crystal type and the structure of the high-temperature form (IH) was solved and refined. The structure of IH differs from that of IL only in the conformation of the molecule, with molecular arrangements being practically unchanged (isostructural conformational transformation). The transition takes place at 313 K with no sign of hysteresis. The volume change, ΔV/V, across the reversible transformation IL IH was calculated and compared to those for the other conformational transformations. Two types of conformational polymorphic transformations (irreversible reconstructive and reversible isostructural) in tolbutamide and chlorpropamide were compared.

AB - Three polymorphs of tolbutamide (IL, II, and III) were studied using single-crystal X-ray diffraction, from 100 K to room temperature (forms II and III) and to 350 K (form I), and differential scanning calorimetry. The reversible transformation, IL IH, was found to be of the single-crystal to single-crystal type and the structure of the high-temperature form (IH) was solved and refined. The structure of IH differs from that of IL only in the conformation of the molecule, with molecular arrangements being practically unchanged (isostructural conformational transformation). The transition takes place at 313 K with no sign of hysteresis. The volume change, ΔV/V, across the reversible transformation IL IH was calculated and compared to those for the other conformational transformations. Two types of conformational polymorphic transformations (irreversible reconstructive and reversible isostructural) in tolbutamide and chlorpropamide were compared.

UR - http://www.scopus.com/inward/record.url?scp=84979902284&partnerID=8YFLogxK

U2 - 10.1039/c6ce00764c

DO - 10.1039/c6ce00764c

M3 - Article

AN - SCOPUS:84979902284

VL - 18

SP - 5736

EP - 5743

JO - CrystEngComm

JF - CrystEngComm

SN - 1466-8033

IS - 30

ER -

ID: 25461686