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Platinum Polyoxoniobates Form Adducts with DNA. / Yudkina, A. V.; Sokolov, M. N.; Abramov, P. A. et al.

In: Russian Journal of Bioorganic Chemistry, Vol. 45, No. 6, 01.11.2019, p. 641-646.

Research output: Contribution to journal › Article › peer-review

Harvard

Yudkina, AV, Sokolov, MN, Abramov, PA, Grin, IR & Zharkov, DO 2019, 'Platinum Polyoxoniobates Form Adducts with DNA', Russian Journal of Bioorganic Chemistry, vol. 45, no. 6, pp. 641-646. https://doi.org/10.1134/S1068162019060414

APA

Yudkina, A. V., Sokolov, M. N., Abramov, P. A., Grin, I. R., & Zharkov, D. O. (2019). Platinum Polyoxoniobates Form Adducts with DNA. Russian Journal of Bioorganic Chemistry, 45(6), 641-646. https://doi.org/10.1134/S1068162019060414

Vancouver

Yudkina AV, Sokolov MN, Abramov PA, Grin IR, Zharkov DO. Platinum Polyoxoniobates Form Adducts with DNA. Russian Journal of Bioorganic Chemistry. 2019 Nov 1;45(6):641-646. doi: 10.1134/S1068162019060414

Author

Yudkina, A. V. ; Sokolov, M. N. ; Abramov, P. A. et al. / Platinum Polyoxoniobates Form Adducts with DNA. In: Russian Journal of Bioorganic Chemistry. 2019 ; Vol. 45, No. 6. pp. 641-646.

BibTeX

@article{ac78a5aa2a8b429ab2e0d4f81aa5df17,
title = "Platinum Polyoxoniobates Form Adducts with DNA",
abstract = "Platinum complexes are among the most commonly prescribed drugs in cancer therapy but show significant toxicity to healthy tissues as a side effect. Platinum polyoxometalates are platinum complexes liganded with cluster anions consisting of oxygen atoms and transition metals. Their properties related to a potential use as anticancer drugs have never been studied. In this paper, we have investigated the effect of platinum (IV) polyoxoniobate of the [Nb6O19{Pt(OH)2}]2 structure containing two platinum centers and two polynuclear Lindqvist type anions on the activity of a number of DNA polymerases belonging to different families (Klenow fragment of Escherichia coli DNA polymerase I, bacteriophage RB69 DNA polymerase, human DNA polymerases β and κ, DNA polymerase IV from Sulfolobus solfataricus). On its own, platinum polyoxoniobate did not act as an inhibitor of DNA polymerases, but was capable of forming adducts with DNA.",
keywords = "DNA damage, DNA polymerases, polyoxometalates, IN-VITRO, POLYOXOMETALATE COMPLEX, POLYMERASES, FUTURE, ANTITUMOR-ACTIVITY",
author = "Yudkina, {A. V.} and Sokolov, {M. N.} and Abramov, {P. A.} and Grin, {I. R.} and Zharkov, {D. O.}",
year = "2019",
month = nov,
day = "1",
doi = "10.1134/S1068162019060414",
language = "English",
volume = "45",
pages = "641--646",
journal = "Russian Journal of Bioorganic Chemistry",
issn = "1068-1620",
publisher = "MAIK NAUKA/INTERPERIODICA/SPRINGER",
number = "6",

}

RIS

TY - JOUR

T1 - Platinum Polyoxoniobates Form Adducts with DNA

AU - Yudkina, A. V.

AU - Sokolov, M. N.

AU - Abramov, P. A.

AU - Grin, I. R.

AU - Zharkov, D. O.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Platinum complexes are among the most commonly prescribed drugs in cancer therapy but show significant toxicity to healthy tissues as a side effect. Platinum polyoxometalates are platinum complexes liganded with cluster anions consisting of oxygen atoms and transition metals. Their properties related to a potential use as anticancer drugs have never been studied. In this paper, we have investigated the effect of platinum (IV) polyoxoniobate of the [Nb6O19{Pt(OH)2}]2 structure containing two platinum centers and two polynuclear Lindqvist type anions on the activity of a number of DNA polymerases belonging to different families (Klenow fragment of Escherichia coli DNA polymerase I, bacteriophage RB69 DNA polymerase, human DNA polymerases β and κ, DNA polymerase IV from Sulfolobus solfataricus). On its own, platinum polyoxoniobate did not act as an inhibitor of DNA polymerases, but was capable of forming adducts with DNA.

AB - Platinum complexes are among the most commonly prescribed drugs in cancer therapy but show significant toxicity to healthy tissues as a side effect. Platinum polyoxometalates are platinum complexes liganded with cluster anions consisting of oxygen atoms and transition metals. Their properties related to a potential use as anticancer drugs have never been studied. In this paper, we have investigated the effect of platinum (IV) polyoxoniobate of the [Nb6O19{Pt(OH)2}]2 structure containing two platinum centers and two polynuclear Lindqvist type anions on the activity of a number of DNA polymerases belonging to different families (Klenow fragment of Escherichia coli DNA polymerase I, bacteriophage RB69 DNA polymerase, human DNA polymerases β and κ, DNA polymerase IV from Sulfolobus solfataricus). On its own, platinum polyoxoniobate did not act as an inhibitor of DNA polymerases, but was capable of forming adducts with DNA.

KW - DNA damage

KW - DNA polymerases

KW - polyoxometalates

KW - IN-VITRO

KW - POLYOXOMETALATE COMPLEX

KW - POLYMERASES

KW - FUTURE

KW - ANTITUMOR-ACTIVITY

UR - http://www.scopus.com/inward/record.url?scp=85077850998&partnerID=8YFLogxK

U2 - 10.1134/S1068162019060414

DO - 10.1134/S1068162019060414

M3 - Article

AN - SCOPUS:85077850998

VL - 45

SP - 641

EP - 646

JO - Russian Journal of Bioorganic Chemistry

JF - Russian Journal of Bioorganic Chemistry

SN - 1068-1620

IS - 6

ER -

ID: 23145286