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Nuclear and mitochondrial DNA sequences from two Denisovan individuals. / Sawyer, Susanna; Renaud, Gabriel; Viola, Bence et al.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, No. 51, 22.12.2015, p. 15696-15700.

Research output: Contribution to journal › Article › peer-review

Harvard

Sawyer, S, Renaud, G, Viola, B, Hublin, JJ, Gansauge, MT, Shunkov, MV, Derevianko, AP, Prüfer, K, Kelso, J & Pääbo, S 2015, 'Nuclear and mitochondrial DNA sequences from two Denisovan individuals', Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 51, pp. 15696-15700. https://doi.org/10.1073/pnas.1519905112

APA

Sawyer, S., Renaud, G., Viola, B., Hublin, J. J., Gansauge, M. T., Shunkov, M. V., Derevianko, A. P., Prüfer, K., Kelso, J., & Pääbo, S. (2015). Nuclear and mitochondrial DNA sequences from two Denisovan individuals. Proceedings of the National Academy of Sciences of the United States of America, 112(51), 15696-15700. https://doi.org/10.1073/pnas.1519905112

Vancouver

Sawyer S, Renaud G, Viola B, Hublin JJ, Gansauge MT, Shunkov MV et al. Nuclear and mitochondrial DNA sequences from two Denisovan individuals. Proceedings of the National Academy of Sciences of the United States of America. 2015 Dec 22;112(51):15696-15700. doi: 10.1073/pnas.1519905112

Author

Sawyer, Susanna ; Renaud, Gabriel ; Viola, Bence et al. / Nuclear and mitochondrial DNA sequences from two Denisovan individuals. In: Proceedings of the National Academy of Sciences of the United States of America. 2015 ; Vol. 112, No. 51. pp. 15696-15700.

BibTeX

@article{af25a4c2872e4be48dafbd98eddcf9b9,
title = "Nuclear and mitochondrial DNA sequences from two Denisovan individuals",
abstract = "Denisovans, a sister group of Neandertals, have been described on the basis of a nuclear genome sequence from a finger phalanx (Denisova 3) found in Denisova Cave in the Altai Mountains. The only other Denisovan specimen described to date is a molar (Denisova 4) found at the same site. This tooth carries a mtDNA sequence similar to that of Denisova 3. Here we present nuclear DNA sequences from Denisova 4 and a morphological description, as well as mitochondrial and nuclear DNA sequence data, from another molar (Denisova 8) found in Denisova Cave in 2010. This new molar is similar to Denisova 4 in being very large and lacking traits typical of Neandertals and modern humans. Nuclear DNA sequences from the two molars form a clade with Denisova 3. The mtDNA of Denisova 8 is more diverged and has accumulated fewer substitutions than the mtDNAs of the other two specimens, suggesting Denisovans were present in the region over an extended period. The nuclear DNA sequence diversity among the three Denisovans is comparable to that among six Neandertals, but lower than that among present-day humans.",
keywords = "Ancient DNA, Denisovans, Neandertals",
author = "Susanna Sawyer and Gabriel Renaud and Bence Viola and Hublin, {Jean Jacques} and Gansauge, {Marie Theres} and Shunkov, {Michael V.} and Derevianko, {Anatoly P.} and Kay Pr{\"u}fer and Janet Kelso and Svante P{\"a}{\"a}bo",
year = "2015",
month = dec,
day = "22",
doi = "10.1073/pnas.1519905112",
language = "English",
volume = "112",
pages = "15696--15700",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "51",

}

RIS

TY - JOUR

T1 - Nuclear and mitochondrial DNA sequences from two Denisovan individuals

AU - Sawyer, Susanna

AU - Renaud, Gabriel

AU - Viola, Bence

AU - Hublin, Jean Jacques

AU - Gansauge, Marie Theres

AU - Shunkov, Michael V.

AU - Derevianko, Anatoly P.

AU - Prüfer, Kay

AU - Kelso, Janet

AU - Pääbo, Svante

PY - 2015/12/22

Y1 - 2015/12/22

N2 - Denisovans, a sister group of Neandertals, have been described on the basis of a nuclear genome sequence from a finger phalanx (Denisova 3) found in Denisova Cave in the Altai Mountains. The only other Denisovan specimen described to date is a molar (Denisova 4) found at the same site. This tooth carries a mtDNA sequence similar to that of Denisova 3. Here we present nuclear DNA sequences from Denisova 4 and a morphological description, as well as mitochondrial and nuclear DNA sequence data, from another molar (Denisova 8) found in Denisova Cave in 2010. This new molar is similar to Denisova 4 in being very large and lacking traits typical of Neandertals and modern humans. Nuclear DNA sequences from the two molars form a clade with Denisova 3. The mtDNA of Denisova 8 is more diverged and has accumulated fewer substitutions than the mtDNAs of the other two specimens, suggesting Denisovans were present in the region over an extended period. The nuclear DNA sequence diversity among the three Denisovans is comparable to that among six Neandertals, but lower than that among present-day humans.

AB - Denisovans, a sister group of Neandertals, have been described on the basis of a nuclear genome sequence from a finger phalanx (Denisova 3) found in Denisova Cave in the Altai Mountains. The only other Denisovan specimen described to date is a molar (Denisova 4) found at the same site. This tooth carries a mtDNA sequence similar to that of Denisova 3. Here we present nuclear DNA sequences from Denisova 4 and a morphological description, as well as mitochondrial and nuclear DNA sequence data, from another molar (Denisova 8) found in Denisova Cave in 2010. This new molar is similar to Denisova 4 in being very large and lacking traits typical of Neandertals and modern humans. Nuclear DNA sequences from the two molars form a clade with Denisova 3. The mtDNA of Denisova 8 is more diverged and has accumulated fewer substitutions than the mtDNAs of the other two specimens, suggesting Denisovans were present in the region over an extended period. The nuclear DNA sequence diversity among the three Denisovans is comparable to that among six Neandertals, but lower than that among present-day humans.

KW - Ancient DNA

KW - Denisovans

KW - Neandertals

UR - http://www.scopus.com/inward/record.url?scp=84952705913&partnerID=8YFLogxK

U2 - 10.1073/pnas.1519905112

DO - 10.1073/pnas.1519905112

M3 - Article

C2 - 26630009

AN - SCOPUS:84952705913

VL - 112

SP - 15696

EP - 15700

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 51

ER -

ID: 25377826