Standard

New genetic lineage within the Siberian subtype of tick-borne encephalitis virus found in Western Siberia, Russia. / Tkachev, Sergey E.; Chicherina, Galina S.; Golovljova, Irina et al.

In: Infection, Genetics and Evolution, Vol. 56, 12.2017, p. 36-43.

Research output: Contribution to journalArticlepeer-review

Harvard

Tkachev, SE, Chicherina, GS, Golovljova, I, Belokopytova, PS, Tikunov, AY, Zadora, OV, Glupov, VV & Tikunova, NV 2017, 'New genetic lineage within the Siberian subtype of tick-borne encephalitis virus found in Western Siberia, Russia', Infection, Genetics and Evolution, vol. 56, pp. 36-43. https://doi.org/10.1016/j.meegid.2017.10.020

APA

Tkachev, S. E., Chicherina, G. S., Golovljova, I., Belokopytova, P. S., Tikunov, A. Y., Zadora, O. V., Glupov, V. V., & Tikunova, N. V. (2017). New genetic lineage within the Siberian subtype of tick-borne encephalitis virus found in Western Siberia, Russia. Infection, Genetics and Evolution, 56, 36-43. https://doi.org/10.1016/j.meegid.2017.10.020

Vancouver

Tkachev SE, Chicherina GS, Golovljova I, Belokopytova PS, Tikunov AY, Zadora OV et al. New genetic lineage within the Siberian subtype of tick-borne encephalitis virus found in Western Siberia, Russia. Infection, Genetics and Evolution. 2017 Dec;56:36-43. doi: 10.1016/j.meegid.2017.10.020

Author

Tkachev, Sergey E. ; Chicherina, Galina S. ; Golovljova, Irina et al. / New genetic lineage within the Siberian subtype of tick-borne encephalitis virus found in Western Siberia, Russia. In: Infection, Genetics and Evolution. 2017 ; Vol. 56. pp. 36-43.

BibTeX

@article{afdeb28d110b4de7a819f247bac7eb07,
title = "New genetic lineage within the Siberian subtype of tick-borne encephalitis virus found in Western Siberia, Russia",
abstract = "Tick-borne encephalitis virus (TBEV), a member of the Flaviviridae family, is a causative agent of a severe neurological disease. There are three main TBEV subtypes: the European (TBEV-Eu), Far Eastern (TBEV-FE), and Siberian (TBEV-Sib). Currently, three lineages within TBEV-Sib have been recorded. In this study, the genetic and biological characteristics of a new original strain, TBEV-2871, isolated in the Novosibirsk province of Western Siberia, Russia were investigated. The strain has low neuroinvasiveness in mice. Phylogenetic analysis demonstrated that TBEV-2871 belongs to TBEV-Sib, but does not cluster with any of the TBEV-Sib lineages. The TBEV-2871 strain has 88–89% nucleotide sequence identity with the other TBEV-Sib strains, 84–86% nucleotide sequence identity with the TBEV-FE and TBEV-Eu subtypes and is genetically close to the subtype division border. The TBEV-2871 polyprotein sequence includes 43 unique amino acid substitutions, 30 of which are recorded at positions that are conserved among all TBEV subtypes. Strain TBEV-2871 and two similar but not identical isolates found in Kemerovo province, Western Siberia are separated into a new lineage tentatively named Obskaya after the name of Ob riber, in the vicinity of which the TBEV-2871 was first found. A molecular evolution investigation demonstrated that within TBEV-Sib, the Obskaya lineage likely separated 1535 years ago, which is even earlier than the Baltic lineage.",
keywords = "Lineages, Siberian subtype, Tick-borne encephalitis virus, Western Siberia, Genome, Viral, Open Reading Frames, Phylogeny, Sequence Analysis, DNA, Animals, Encephalitis Viruses, Tick-Borne/classification, Mice, Siberia/epidemiology, Encephalitis, Tick-Borne/epidemiology",
author = "Tkachev, {Sergey E.} and Chicherina, {Galina S.} and Irina Golovljova and Belokopytova, {Polina S.} and Tikunov, {Artem Yu} and Zadora, {Oksana V.} and Glupov, {Victor V.} and Tikunova, {Nina V.}",
note = "Funding Information: This study was supported by the Russian Scientific Foundation (project No. 15-14-20020 ). Publisher Copyright: {\textcopyright} 2017 Elsevier B.V. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "2017",
month = dec,
doi = "10.1016/j.meegid.2017.10.020",
language = "English",
volume = "56",
pages = "36--43",
journal = "Infection, Genetics and Evolution",
issn = "1567-1348",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - New genetic lineage within the Siberian subtype of tick-borne encephalitis virus found in Western Siberia, Russia

AU - Tkachev, Sergey E.

AU - Chicherina, Galina S.

AU - Golovljova, Irina

AU - Belokopytova, Polina S.

AU - Tikunov, Artem Yu

AU - Zadora, Oksana V.

AU - Glupov, Victor V.

AU - Tikunova, Nina V.

N1 - Funding Information: This study was supported by the Russian Scientific Foundation (project No. 15-14-20020 ). Publisher Copyright: © 2017 Elsevier B.V. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2017/12

Y1 - 2017/12

N2 - Tick-borne encephalitis virus (TBEV), a member of the Flaviviridae family, is a causative agent of a severe neurological disease. There are three main TBEV subtypes: the European (TBEV-Eu), Far Eastern (TBEV-FE), and Siberian (TBEV-Sib). Currently, three lineages within TBEV-Sib have been recorded. In this study, the genetic and biological characteristics of a new original strain, TBEV-2871, isolated in the Novosibirsk province of Western Siberia, Russia were investigated. The strain has low neuroinvasiveness in mice. Phylogenetic analysis demonstrated that TBEV-2871 belongs to TBEV-Sib, but does not cluster with any of the TBEV-Sib lineages. The TBEV-2871 strain has 88–89% nucleotide sequence identity with the other TBEV-Sib strains, 84–86% nucleotide sequence identity with the TBEV-FE and TBEV-Eu subtypes and is genetically close to the subtype division border. The TBEV-2871 polyprotein sequence includes 43 unique amino acid substitutions, 30 of which are recorded at positions that are conserved among all TBEV subtypes. Strain TBEV-2871 and two similar but not identical isolates found in Kemerovo province, Western Siberia are separated into a new lineage tentatively named Obskaya after the name of Ob riber, in the vicinity of which the TBEV-2871 was first found. A molecular evolution investigation demonstrated that within TBEV-Sib, the Obskaya lineage likely separated 1535 years ago, which is even earlier than the Baltic lineage.

AB - Tick-borne encephalitis virus (TBEV), a member of the Flaviviridae family, is a causative agent of a severe neurological disease. There are three main TBEV subtypes: the European (TBEV-Eu), Far Eastern (TBEV-FE), and Siberian (TBEV-Sib). Currently, three lineages within TBEV-Sib have been recorded. In this study, the genetic and biological characteristics of a new original strain, TBEV-2871, isolated in the Novosibirsk province of Western Siberia, Russia were investigated. The strain has low neuroinvasiveness in mice. Phylogenetic analysis demonstrated that TBEV-2871 belongs to TBEV-Sib, but does not cluster with any of the TBEV-Sib lineages. The TBEV-2871 strain has 88–89% nucleotide sequence identity with the other TBEV-Sib strains, 84–86% nucleotide sequence identity with the TBEV-FE and TBEV-Eu subtypes and is genetically close to the subtype division border. The TBEV-2871 polyprotein sequence includes 43 unique amino acid substitutions, 30 of which are recorded at positions that are conserved among all TBEV subtypes. Strain TBEV-2871 and two similar but not identical isolates found in Kemerovo province, Western Siberia are separated into a new lineage tentatively named Obskaya after the name of Ob riber, in the vicinity of which the TBEV-2871 was first found. A molecular evolution investigation demonstrated that within TBEV-Sib, the Obskaya lineage likely separated 1535 years ago, which is even earlier than the Baltic lineage.

KW - Lineages

KW - Siberian subtype

KW - Tick-borne encephalitis virus

KW - Western Siberia

KW - Genome, Viral

KW - Open Reading Frames

KW - Phylogeny

KW - Sequence Analysis, DNA

KW - Animals

KW - Encephalitis Viruses, Tick-Borne/classification

KW - Mice

KW - Siberia/epidemiology

KW - Encephalitis, Tick-Borne/epidemiology

UR - http://www.scopus.com/inward/record.url?scp=85032380215&partnerID=8YFLogxK

U2 - 10.1016/j.meegid.2017.10.020

DO - 10.1016/j.meegid.2017.10.020

M3 - Article

C2 - 29069610

AN - SCOPUS:85032380215

VL - 56

SP - 36

EP - 43

JO - Infection, Genetics and Evolution

JF - Infection, Genetics and Evolution

SN - 1567-1348

ER -

ID: 27709743