Modern approaches to modification of bile acids for the synthesis of compounds possessing valuable physicochemical and biological properties

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Modern approaches to modification of bile acids for the synthesis of compounds possessing valuable physicochemical and biological properties. / Popadyuk, Irina I.; Salomatina, Oksana V.; Salakhutdinov, Nariman F.

In: Russian Chemical Reviews, Vol. 86, No. 5, 2017, p. 388-443.

Research output: Contribution to journal › Review article › peer-review

BibTeX

@article{20d79412a3b942e2addc5ce69597bb24,

title = "Modern approaches to modification of bile acids for the synthesis of compounds possessing valuable physicochemical and biological properties",

abstract = "Data published in the period from 2000 to 2015 on chemical transformations of the major human bile acids (cholic, chenodeoxycholic, deoxycholic and lithocholic acids) and ursodeoxycholic acid are integrated and described systematically. Characteristic features of their structures, biosynthesis, main sources and biological functions are considered. The data on chemical transformations of the indicated bile acids include reactions involving modifications of the side chain or the steroid nucleus. The biological activities and applications of these derivatives are surveyed in brief. The bibliography includes 227 references.",

keywords = "RECEPTOR 1 GP-BAR1, PALLADIUM-CATALYZED AMINATION, CARBONIC-ANHYDRASE INHIBITORS, RING-CLOSING METATHESIS, O-IODOXYBENZOIC ACID, FARNESOID-X-RECEPTOR, ALPHA-AMINO-ACIDS, CHOLIC-ACID, URSODEOXYCHOLIC ACID, IN-VITRO",

author = "Popadyuk, {Irina I.} and Salomatina, {Oksana V.} and Salakhutdinov, {Nariman F.}",

year = "2017",

doi = "10.1070/RCR4683",

language = "English",

volume = "86",

pages = "388--443",

journal = "Russian Chemical Reviews",

issn = "0036-021X",

publisher = "Turpion Ltd.",

number = "5",

}

RIS

TY - JOUR

T1 - Modern approaches to modification of bile acids for the synthesis of compounds possessing valuable physicochemical and biological properties

AU - Popadyuk, Irina I.

AU - Salomatina, Oksana V.

AU - Salakhutdinov, Nariman F.

PY - 2017

Y1 - 2017

N2 - Data published in the period from 2000 to 2015 on chemical transformations of the major human bile acids (cholic, chenodeoxycholic, deoxycholic and lithocholic acids) and ursodeoxycholic acid are integrated and described systematically. Characteristic features of their structures, biosynthesis, main sources and biological functions are considered. The data on chemical transformations of the indicated bile acids include reactions involving modifications of the side chain or the steroid nucleus. The biological activities and applications of these derivatives are surveyed in brief. The bibliography includes 227 references.

AB - Data published in the period from 2000 to 2015 on chemical transformations of the major human bile acids (cholic, chenodeoxycholic, deoxycholic and lithocholic acids) and ursodeoxycholic acid are integrated and described systematically. Characteristic features of their structures, biosynthesis, main sources and biological functions are considered. The data on chemical transformations of the indicated bile acids include reactions involving modifications of the side chain or the steroid nucleus. The biological activities and applications of these derivatives are surveyed in brief. The bibliography includes 227 references.

KW - RECEPTOR 1 GP-BAR1

KW - PALLADIUM-CATALYZED AMINATION

KW - CARBONIC-ANHYDRASE INHIBITORS

KW - RING-CLOSING METATHESIS

KW - O-IODOXYBENZOIC ACID

KW - FARNESOID-X-RECEPTOR

KW - ALPHA-AMINO-ACIDS

KW - CHOLIC-ACID

KW - URSODEOXYCHOLIC ACID

KW - IN-VITRO

UR - http://www.scopus.com/inward/record.url?scp=85020265352&partnerID=8YFLogxK

U2 - 10.1070/RCR4683

DO - 10.1070/RCR4683

M3 - Review article

AN - SCOPUS:85020265352

VL - 86

SP - 388

EP - 443

JO - Russian Chemical Reviews

JF - Russian Chemical Reviews

SN - 0036-021X

IS - 5

ER -

ID: 9560787