TY - JOUR

T1 - Meet your MAKR: the membrane-associated kinase regulator protein family in the regulation of plant development

AU - Novikova, Daria D.

AU - Korosteleva, Anastasia L.

AU - Mironova, Victoria

AU - Jaillais, Yvon

N1 - Funding Information: We thank Nadya Omelyanchuk, Alexey Doroshkov, Mar Marquès and Laia Armengot for fruitful discussions as well as all the members of the SiCE group. We thank Wei Xuan and Tom Beeckman for providing the MAKR4prom::GFP‐MAKR4 micrograph, as well as Yeon Hee Kang and Christian Hardtke for the MAKR5prom::MAKR5‐GFP micrograph. Promoter analysis was funded by RFBR and Novosibirsk Region according to the research project No 19‐44‐543006; phylogenetic analysis was funded by the Budget Project 0259‐2021‐0009. Research on MAKRs in YJ lab was founded by ERC grant 3363360‐APPL under FP/2007–2013 and an ANR‐supported ERA‐CAPS project (SICOPID: ANR‐17‐CAPS‐0003‐01). Publisher Copyright: © 2021 Federation of European Biochemical Societies.

PY - 2022/10

Y1 - 2022/10

N2 - A small family composed of BRI1 KINASE INHIBITOR1 (BKI1) and MEMBRANE-ASSOCIATED KINASE REGULATORS (MAKRs) has recently captured the attention of plant biologists, due to their involvement in developmental processes downstream of hormones and Receptor-Like Kinases (RLK) signalling. BKI1/MAKRs are intrinsically disordered proteins (so-called unstructured proteins) and as such lack specific domains. Instead, they are defined by the presence of two conserved linear motifs involved in the interaction with lipids and proteins, respectively. Here, we first relate the discovery of the MAKR gene family. Then, we review the individual function of characterized family members and discuss their shared and specific modes of action. Finally, we explore and summarize the structural, comparative and functional genomics data available on this gene family. Together, this review aims at building a comprehensive reference about BKI1/MAKR protein function in plants.

AB - A small family composed of BRI1 KINASE INHIBITOR1 (BKI1) and MEMBRANE-ASSOCIATED KINASE REGULATORS (MAKRs) has recently captured the attention of plant biologists, due to their involvement in developmental processes downstream of hormones and Receptor-Like Kinases (RLK) signalling. BKI1/MAKRs are intrinsically disordered proteins (so-called unstructured proteins) and as such lack specific domains. Instead, they are defined by the presence of two conserved linear motifs involved in the interaction with lipids and proteins, respectively. Here, we first relate the discovery of the MAKR gene family. Then, we review the individual function of characterized family members and discuss their shared and specific modes of action. Finally, we explore and summarize the structural, comparative and functional genomics data available on this gene family. Together, this review aims at building a comprehensive reference about BKI1/MAKR protein function in plants.

KW - auxin

KW - brassinosteroids

KW - lateral root

KW - receptor-like kinase

KW - vascular development

KW - Hormones/metabolism

KW - Intrinsically Disordered Proteins/metabolism

KW - Signal Transduction/genetics

KW - Arabidopsis/genetics

KW - Membrane Proteins/genetics

KW - Brassinosteroids

KW - Plants/genetics

KW - Protein Kinases/metabolism

KW - Gene Expression Regulation, Plant

KW - Plant Development/genetics

KW - Arabidopsis Proteins/metabolism

UR - http://www.scopus.com/inward/record.url?scp=85111818012&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/a55706f7-d11b-351b-bd9c-7db72717e383/

U2 - 10.1111/febs.16132

DO - 10.1111/febs.16132

M3 - Review article

C2 - 34288456

AN - SCOPUS:85111818012

VL - 289

SP - 6172

EP - 6186

JO - FEBS Journal

JF - FEBS Journal

SN - 1742-464X

IS - 20

ER -