Introducing an expanded CAG tract into the huntingtin gene causes a wide spectrum of ultrastructural defects in cultured human cells

Research output: Contribution to journal › Article › peer-review

CRISPR-Cas Systems, Clone Cells/metabolism, Endoplasmic Reticulum/ultrastructure, Gene Knockout Techniques, HEK293 Cells, Humans, Huntingtin Protein/antagonists & inhibitors, Huntington Disease/genetics, Lysosomes/ultrastructure, Microscopy, Electron, Transmission, Mitochondria/ultrastructure, Mutant Proteins/genetics, Mutation, Trinucleotide Repeat Expansion, MUTANT HUNTINGTIN, MITOPHAGY, AUTOPHAGY, NUCLEAR-MEMBRANE, PATHOGENESIS, PLURIPOTENT STEM-CELLS, MITOCHONDRIAL DYNAMICS, DISEASE, BRAIN, LYSOSOMAL ACTIVITY

ID: 17179797