Influence of pyridine-like ligands on the structure, photochemical and biological properties of nitro-nitrosyl ruthenium complexes

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Influence of pyridine-like ligands on the structure, photochemical and biological properties of nitro-nitrosyl ruthenium complexes. / Kostin, G. A.; Mikhailov, A. A.; Kuratieva, N. V. et al.

In: New Journal of Chemistry, Vol. 41, No. 15, 07.08.2017, p. 7758-7765.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{4eac33794f49485482d93218188611c8,

title = "Influence of pyridine-like ligands on the structure, photochemical and biological properties of nitro-nitrosyl ruthenium complexes",

abstract = "Under identical synthetic conditions, the reaction of aqua-nitro complexes of ruthenium nitrosyl with methyl-substituted pyridines results in drastically different products. While 3- and 4-MePy react similarly to pyridine giving monomeric complexes [RuNO(NO2)2L2OH] with good yields (70-80%), the sterically hindered 2-MePy forms a dimeric complex [(RuNO(2-MePy)(NO2)(μ-NO2))2μ-O] with only one N-heterocycle coordinated to the ruthenium center. Further investigation of photoinduced (445 nm) isomerization of Ru-NO (GS) to Ru-ON (MS1) at 80 K also shows different behaviors. Complexes with 3- and 4-MePy form metastable states with populations equal to 25% and 40% according to IR spectroscopy data. Activation parameters for the reverse decay reaction (MS1 → GS) determined from DSC are lgk0 = 12.0(0.2), Ea = 56.0(0.7) kJ mole-1 and lgk0 = 13.7(0.1), Ea = 61.8(0.4) kJ mole-1 for the 3-MePy and 4-MePy complex. A dimeric complex with 2-MePy does not undergo any changes after irradiation. Estimates of cytotoxicity in human mammary adenocarcinoma (MCF-7) and immortalized human embryonic kidney (HEK-293) cell lines demonstrate that complexes with 3-MePy and 4-MePy exhibited a 50% decrease in the growth of cancer cells at remarkably low and comparable concentrations (0.82-3.2 μM).",

keywords = "CRYSTAL-STRUCTURES, ELECTROCHEMICAL PROPERTIES, CELLULAR ACCUMULATION, ARENE COMPLEXES, IN-VITRO, OXIDE, NO, CYTOTOXICITY, LIGHT, REACTIVITY",

author = "Kostin, {G. A.} and Mikhailov, {A. A.} and Kuratieva, {N. V.} and Pischur, {D. P.} and Zharkov, {D. O.} and Grin, {I. R.}",

year = "2017",

month = aug,

day = "7",

doi = "10.1039/c7nj01602f",

language = "English",

volume = "41",

pages = "7758--7765",

journal = "New Journal of Chemistry",

issn = "1144-0546",

publisher = "ROYAL SOC CHEMISTRY",

number = "15",

}

RIS

TY - JOUR

T1 - Influence of pyridine-like ligands on the structure, photochemical and biological properties of nitro-nitrosyl ruthenium complexes

AU - Kostin, G. A.

AU - Mikhailov, A. A.

AU - Kuratieva, N. V.

AU - Pischur, D. P.

AU - Zharkov, D. O.

AU - Grin, I. R.

PY - 2017/8/7

Y1 - 2017/8/7

N2 - Under identical synthetic conditions, the reaction of aqua-nitro complexes of ruthenium nitrosyl with methyl-substituted pyridines results in drastically different products. While 3- and 4-MePy react similarly to pyridine giving monomeric complexes [RuNO(NO2)2L2OH] with good yields (70-80%), the sterically hindered 2-MePy forms a dimeric complex [(RuNO(2-MePy)(NO2)(μ-NO2))2μ-O] with only one N-heterocycle coordinated to the ruthenium center. Further investigation of photoinduced (445 nm) isomerization of Ru-NO (GS) to Ru-ON (MS1) at 80 K also shows different behaviors. Complexes with 3- and 4-MePy form metastable states with populations equal to 25% and 40% according to IR spectroscopy data. Activation parameters for the reverse decay reaction (MS1 → GS) determined from DSC are lgk0 = 12.0(0.2), Ea = 56.0(0.7) kJ mole-1 and lgk0 = 13.7(0.1), Ea = 61.8(0.4) kJ mole-1 for the 3-MePy and 4-MePy complex. A dimeric complex with 2-MePy does not undergo any changes after irradiation. Estimates of cytotoxicity in human mammary adenocarcinoma (MCF-7) and immortalized human embryonic kidney (HEK-293) cell lines demonstrate that complexes with 3-MePy and 4-MePy exhibited a 50% decrease in the growth of cancer cells at remarkably low and comparable concentrations (0.82-3.2 μM).

AB - Under identical synthetic conditions, the reaction of aqua-nitro complexes of ruthenium nitrosyl with methyl-substituted pyridines results in drastically different products. While 3- and 4-MePy react similarly to pyridine giving monomeric complexes [RuNO(NO2)2L2OH] with good yields (70-80%), the sterically hindered 2-MePy forms a dimeric complex [(RuNO(2-MePy)(NO2)(μ-NO2))2μ-O] with only one N-heterocycle coordinated to the ruthenium center. Further investigation of photoinduced (445 nm) isomerization of Ru-NO (GS) to Ru-ON (MS1) at 80 K also shows different behaviors. Complexes with 3- and 4-MePy form metastable states with populations equal to 25% and 40% according to IR spectroscopy data. Activation parameters for the reverse decay reaction (MS1 → GS) determined from DSC are lgk0 = 12.0(0.2), Ea = 56.0(0.7) kJ mole-1 and lgk0 = 13.7(0.1), Ea = 61.8(0.4) kJ mole-1 for the 3-MePy and 4-MePy complex. A dimeric complex with 2-MePy does not undergo any changes after irradiation. Estimates of cytotoxicity in human mammary adenocarcinoma (MCF-7) and immortalized human embryonic kidney (HEK-293) cell lines demonstrate that complexes with 3-MePy and 4-MePy exhibited a 50% decrease in the growth of cancer cells at remarkably low and comparable concentrations (0.82-3.2 μM).

KW - CRYSTAL-STRUCTURES

KW - ELECTROCHEMICAL PROPERTIES

KW - CELLULAR ACCUMULATION

KW - ARENE COMPLEXES

KW - IN-VITRO

KW - OXIDE

KW - NO

KW - CYTOTOXICITY

KW - LIGHT

KW - REACTIVITY

UR - http://www.scopus.com/inward/record.url?scp=85026321033&partnerID=8YFLogxK

U2 - 10.1039/c7nj01602f

DO - 10.1039/c7nj01602f

M3 - Article

AN - SCOPUS:85026321033

VL - 41

SP - 7758

EP - 7765

JO - New Journal of Chemistry

JF - New Journal of Chemistry

SN - 1144-0546

IS - 15

ER -

ID: 8672843