Research output: Contribution to journal › Article › peer-review
How intramolecular coordination bonding (ICB) controls the homolysis of the C-ON bond in alkoxyamines. / Audran, Gérard; Bagryanskaya, Elena; Bagryanskaya, Irina et al.
In: RSC Advances, Vol. 9, No. 44, 18.08.2019, p. 25776-25789.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - How intramolecular coordination bonding (ICB) controls the homolysis of the C-ON bond in alkoxyamines
AU - Audran, Gérard
AU - Bagryanskaya, Elena
AU - Bagryanskaya, Irina
AU - Edeleva, Mariya
AU - Joly, Jean Patrick
AU - Marque, Sylvain R.A.
AU - Iurchenkova, Anna
AU - Kaletina, Polina
AU - Cherkasov, Sergey
AU - Hai, Tung To
AU - Tretyakov, Evgeny
AU - Zhivetyeva, Svetlana
N1 - This journal is © The Royal Society of Chemistry.
PY - 2019/8/18
Y1 - 2019/8/18
N2 - Because the C-ON bond homolysis rate constant kd is an essential parameter of alkoxyamine reactivity, it is especially important to tune kd without a major alteration of the structure of the molecule. Recently, several approaches have become known, e.g., protonation of functional groups and formation of metal complexes. In this paper, coordination reactions of [Zn(hfac)2(H2O)2] with a series of new SG1-based alkoxyamines affording complexes with different structures are presented. The kd values of the complexed forms of the alkoxyamines were compared to those of free and protonated ones to reveal the contribution of the electron-withdrawing property and structure stabilization. Together with previously published data, this work provides clues to the design of alkoxyamines that can be effectively activated upon coordination with metal ions. Furthermore, our results provide insight into the mechanism underlying the influence of complexation on the reactivity of alkoxyamines. This led us to describe different types of coordination: Intramolecular in nitroxyl fragment, intramolecular in alkyl fragment, intramolecular between alkyl and nitroxyl fragment, and intermolecular one. All of them exhibit different trends which are dramatically altered by changes in conformation.
AB - Because the C-ON bond homolysis rate constant kd is an essential parameter of alkoxyamine reactivity, it is especially important to tune kd without a major alteration of the structure of the molecule. Recently, several approaches have become known, e.g., protonation of functional groups and formation of metal complexes. In this paper, coordination reactions of [Zn(hfac)2(H2O)2] with a series of new SG1-based alkoxyamines affording complexes with different structures are presented. The kd values of the complexed forms of the alkoxyamines were compared to those of free and protonated ones to reveal the contribution of the electron-withdrawing property and structure stabilization. Together with previously published data, this work provides clues to the design of alkoxyamines that can be effectively activated upon coordination with metal ions. Furthermore, our results provide insight into the mechanism underlying the influence of complexation on the reactivity of alkoxyamines. This led us to describe different types of coordination: Intramolecular in nitroxyl fragment, intramolecular in alkyl fragment, intramolecular between alkyl and nitroxyl fragment, and intermolecular one. All of them exhibit different trends which are dramatically altered by changes in conformation.
KW - NITROXIDE-MEDIATED POLYMERIZATION
KW - FREE-ENERGY RELATIONSHIPS
KW - POLAR
KW - QUATERNIZATION
KW - IMIDAZOLINE
KW - ZINC(II)
KW - FAMILY
KW - AGENTS
UR - http://www.scopus.com/inward/record.url?scp=85071165823&partnerID=8YFLogxK
U2 - 10.1039/c9ra05334d
DO - 10.1039/c9ra05334d
M3 - Article
C2 - 35530086
AN - SCOPUS:85071165823
VL - 9
SP - 25776
EP - 25789
JO - RSC Advances
JF - RSC Advances
SN - 2046-2069
IS - 44
ER -
ID: 21345028