Research output: Contribution to journal › Article › peer-review
Generation of induced pluripotent stem cell line, ICGi007-A, by reprogramming peripheral blood mononuclear cells from a patient with Huntington's disease. / Grigor'eva, E. V.; Malankhanova, T. B.; Surumbayeva, A. et al.
In: Stem Cell Research, Vol. 34, 101382, 01.01.2019.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Generation of induced pluripotent stem cell line, ICGi007-A, by reprogramming peripheral blood mononuclear cells from a patient with Huntington's disease
AU - Grigor'eva, E. V.
AU - Malankhanova, T. B.
AU - Surumbayeva, A.
AU - Minina, J. M.
AU - Morozov, V. V.
AU - Abramycheva, N. Yu
AU - Illarioshkin, S. N.
AU - Malakhova, A. A.
AU - Zakian, S. M.
N1 - Publisher Copyright: © 2019 The Authors
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by mutation in the HTT gene encoding HTT protein. The mutant protein leads to the neuronal death through dysregulation of multiple cellular processes. HD human induced pluripotent stem cells (iPSCs) represent a useful and valid model for the disease study. iPSC line from HD patient with 47 CAG repeats in HTT was generated from blood mononuclear cells by non-integrating episomal vectors. The iPSC line retained the mutation, expressed pluripotency markers, had a normal karyotype and displayed in vitro differentiation to the three germ layers.
AB - Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by mutation in the HTT gene encoding HTT protein. The mutant protein leads to the neuronal death through dysregulation of multiple cellular processes. HD human induced pluripotent stem cells (iPSCs) represent a useful and valid model for the disease study. iPSC line from HD patient with 47 CAG repeats in HTT was generated from blood mononuclear cells by non-integrating episomal vectors. The iPSC line retained the mutation, expressed pluripotency markers, had a normal karyotype and displayed in vitro differentiation to the three germ layers.
KW - Adult
KW - Cell Culture Techniques/methods
KW - Cell Line
KW - Cellular Reprogramming
KW - Female
KW - Humans
KW - Huntington Disease/blood
KW - Induced Pluripotent Stem Cells/pathology
KW - Leukocytes, Mononuclear/pathology
UR - http://www.scopus.com/inward/record.url?scp=85059966398&partnerID=8YFLogxK
U2 - 10.1016/j.scr.2018.101382
DO - 10.1016/j.scr.2018.101382
M3 - Article
C2 - 30658253
AN - SCOPUS:85059966398
VL - 34
JO - Stem Cell Research
JF - Stem Cell Research
SN - 1873-5061
M1 - 101382
ER -
ID: 18142199