Generation of an induced pluripotent stem cell line, ICGi014-A, by reprogramming peripheral blood mononuclear cells from a patient with homozygous D90A mutation in SOD1 causing Amyotrophic lateral sclerosis

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Generation of an induced pluripotent stem cell line, ICGi014-A, by reprogramming peripheral blood mononuclear cells from a patient with homozygous D90A mutation in SOD1 causing Amyotrophic lateral sclerosis. / Ustyantseva, E. I.; Medvedev, S. P.; Vetchinova, A. S. et al.

In: Stem Cell Research, Vol. 42, 101675, 01.2020.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{1ec240b225904832b11e07a37f2cbca0,

title = "Generation of an induced pluripotent stem cell line, ICGi014-A, by reprogramming peripheral blood mononuclear cells from a patient with homozygous D90A mutation in SOD1 causing Amyotrophic lateral sclerosis",

abstract = "Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by death of motor neurons. To date, neither etiology nor pathogenesis of ALS are known, which leads to the absence of an effective treatment strategy. ALS patient-specific induced pluripotent stem cells (iPSCs) represent an excellent tool for the disease study. We obtained iPSCs line from peripheral blood mononuclear cells of the patient with homozygous Asp90Ala mutation in the SOD1 gene using non-integrating episomal vectors. The iPSCs line retained pathological genotype and expressed pluripotency markers. It also displayed a normal karyotype and the ability to differentiate into derivatives of three germ layers.",

author = "Ustyantseva, {E. I.} and Medvedev, {S. P.} and Vetchinova, {A. S.} and Illarioshkin, {S. N.} and Leonov, {S. V.} and Zakian, {S. M.}",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2020",

month = jan,

doi = "10.1016/j.scr.2019.101675",

language = "English",

volume = "42",

journal = "Stem Cell Research",

issn = "1873-5061",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Generation of an induced pluripotent stem cell line, ICGi014-A, by reprogramming peripheral blood mononuclear cells from a patient with homozygous D90A mutation in SOD1 causing Amyotrophic lateral sclerosis

AU - Ustyantseva, E. I.

AU - Medvedev, S. P.

AU - Vetchinova, A. S.

AU - Illarioshkin, S. N.

AU - Leonov, S. V.

AU - Zakian, S. M.

PY - 2020/1

Y1 - 2020/1

N2 - Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by death of motor neurons. To date, neither etiology nor pathogenesis of ALS are known, which leads to the absence of an effective treatment strategy. ALS patient-specific induced pluripotent stem cells (iPSCs) represent an excellent tool for the disease study. We obtained iPSCs line from peripheral blood mononuclear cells of the patient with homozygous Asp90Ala mutation in the SOD1 gene using non-integrating episomal vectors. The iPSCs line retained pathological genotype and expressed pluripotency markers. It also displayed a normal karyotype and the ability to differentiate into derivatives of three germ layers.

AB - Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by death of motor neurons. To date, neither etiology nor pathogenesis of ALS are known, which leads to the absence of an effective treatment strategy. ALS patient-specific induced pluripotent stem cells (iPSCs) represent an excellent tool for the disease study. We obtained iPSCs line from peripheral blood mononuclear cells of the patient with homozygous Asp90Ala mutation in the SOD1 gene using non-integrating episomal vectors. The iPSCs line retained pathological genotype and expressed pluripotency markers. It also displayed a normal karyotype and the ability to differentiate into derivatives of three germ layers.

UR - http://www.scopus.com/inward/record.url?scp=85076030585&partnerID=8YFLogxK

U2 - 10.1016/j.scr.2019.101675

DO - 10.1016/j.scr.2019.101675

M3 - Article

C2 - 31830646

AN - SCOPUS:85076030585

VL - 42

JO - Stem Cell Research

JF - Stem Cell Research

SN - 1873-5061

M1 - 101675

ER -

ID: 22600169