Research output: Contribution to journal › Article › peer-review
Food, drug and model mix analysis by organic monolithic columns based on heterocyclic monomers. / Sotnikova, Yulia S.; Patrushev, Yuri V.
In: Journal of Liquid Chromatography and Related Technologies, Vol. 46, No. 11-15, 2023, p. 211-217.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Food, drug and model mix analysis by organic monolithic columns based on heterocyclic monomers
AU - Sotnikova, Yulia S.
AU - Patrushev, Yuri V.
N1 - This work was supported Ministry of Science and Higher Education of the Russian Federation within the governmental order for Boreskov Institute of Catalysis (project АААА-А21-121011390053-4).
PY - 2023
Y1 - 2023
N2 - This paper presents examples of separation on monolithic columns prepared by two different methods: copolymerization and post-modification. In the first method, monoliths were prepared from styrene, divinylbenzene, and heterocyclic nitrogen-containing monomers. In the second, a styrene/divinylbenzene/4-vinylbenzyl chloride copolymer was obtained and in situ modified with 1-methylimidazole. It has been shown that monolithic columns are capable of separating macromolecules and low-molecular compounds. A comparison was made between a styrene/divinylbenzene/1-vinylimidazole copolymer column and a ProSwift™ RP-3U monolithic column. It has been established that a monolithic column based on 1-vinylimidazole is capable of separating proteins and low molecular weight test substances. However, the ProSwift™ RP-3U column is only capable of separating proteins. Separation examples are given: a test mixture of proteins, natural milk proteins, carbohydrates and drugs on a column with a sorbent based on styrene/divinylbenzene. A modified column was used to study the content of salicylic acid in medicinal preparations containing acetylsalicylic acid.
AB - This paper presents examples of separation on monolithic columns prepared by two different methods: copolymerization and post-modification. In the first method, monoliths were prepared from styrene, divinylbenzene, and heterocyclic nitrogen-containing monomers. In the second, a styrene/divinylbenzene/4-vinylbenzyl chloride copolymer was obtained and in situ modified with 1-methylimidazole. It has been shown that monolithic columns are capable of separating macromolecules and low-molecular compounds. A comparison was made between a styrene/divinylbenzene/1-vinylimidazole copolymer column and a ProSwift™ RP-3U monolithic column. It has been established that a monolithic column based on 1-vinylimidazole is capable of separating proteins and low molecular weight test substances. However, the ProSwift™ RP-3U column is only capable of separating proteins. Separation examples are given: a test mixture of proteins, natural milk proteins, carbohydrates and drugs on a column with a sorbent based on styrene/divinylbenzene. A modified column was used to study the content of salicylic acid in medicinal preparations containing acetylsalicylic acid.
KW - HPLC
KW - macromolecules separating
KW - mixed-mode chromatography
KW - monolithic columns
KW - porous polymer
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85165259456&origin=inward&txGid=b14f19d3d6abf47ac1b317a0778d7c29
UR - https://www.mendeley.com/catalogue/1282b78c-36b7-3048-a4f9-98d75b34835f/
U2 - 10.1080/10826076.2023.2235402
DO - 10.1080/10826076.2023.2235402
M3 - Article
VL - 46
SP - 211
EP - 217
JO - Journal of Liquid Chromatography and Related Technologies
JF - Journal of Liquid Chromatography and Related Technologies
SN - 1082-6076
IS - 11-15
ER -
ID: 59126760