Features of retinal neurogenesis as a key factor of age-related neurodegeneration: Myth or reality?

Standard

Features of retinal neurogenesis as a key factor of age-related neurodegeneration: Myth or reality? / Telegina, Darya V.; Kozhevnikova, Oyuna S.; Antonenko, Anna K. et al.

In: International Journal of Molecular Sciences, Vol. 22, No. 14, 7373, 02.07.2021.

Research output: Contribution to journal › Review article › peer-review

Harvard

Telegina, DV, Kozhevnikova, OS, Antonenko, AK & Kolosova, NG 2021, 'Features of retinal neurogenesis as a key factor of age-related neurodegeneration: Myth or reality?', International Journal of Molecular Sciences, vol. 22, no. 14, 7373. https://doi.org/10.3390/ijms22147373

APA

Telegina, D. V., Kozhevnikova, O. S., Antonenko, A. K., & Kolosova, N. G. (2021). Features of retinal neurogenesis as a key factor of age-related neurodegeneration: Myth or reality? International Journal of Molecular Sciences, 22(14), [7373]. https://doi.org/10.3390/ijms22147373

Vancouver

Telegina DV, Kozhevnikova OS, Antonenko AK, Kolosova NG. Features of retinal neurogenesis as a key factor of age-related neurodegeneration: Myth or reality? International Journal of Molecular Sciences. 2021 Jul 2;22(14):7373. doi: 10.3390/ijms22147373

Author

Telegina, Darya V. ; Kozhevnikova, Oyuna S. ; Antonenko, Anna K. et al. / Features of retinal neurogenesis as a key factor of age-related neurodegeneration: Myth or reality?. In: International Journal of Molecular Sciences. 2021 ; Vol. 22, No. 14.

BibTeX

@article{9e57cfbfe2784d1d8a8cb6259095bc9d,

title = "Features of retinal neurogenesis as a key factor of age-related neurodegeneration: Myth or reality?",

abstract = "Age-related macular degeneration (AMD) is a complex multifactorial neurodegenerative disease that constitutes the most common cause of irreversible blindness in the elderly in the developed countries. Incomplete knowledge about its pathogenesis prevents the search for effective methods of prevention and treatment of AMD, primarily of its “dry” type which is by far the most common (90% of all AMD cases). In the recent years, AMD has become “younger”: late stages of the disease are now detected in relatively young people. It is known that AMD pathogenesis—according to the age-related structural and functional changes in the retina—is linked with inflammation, hypoxia, oxidative stress, mitochondrial dysfunction, and an impairment of neurotrophic support, but the mechanisms that trigger the conversion of normal age-related changes to the pathological process as well as the reason for early AMD development remain unclear. In the adult mammalian retina, de novo neurogenesis is very limited. Therefore, the structural and functional features that arise during its maturation and formation can exert long-term effects on further ontogenesis of this tissue. The aim of this review was to discuss possible contributions of the changes/disturbances in retinal neurogenesis to the early development of AMD.",

keywords = "Aging, AMD, Development, Neurodegeneration, Neurogenesis, Retina, Transcription factor, Aging/genetics, Macular Degeneration/etiology, Humans, Retina/growth & development, Transcription Factors/genetics, Neurodegenerative Diseases/genetics, Neurogenesis/drug effects, Animals, Inflammation/genetics",

author = "Telegina, {Darya V.} and Kozhevnikova, {Oyuna S.} and Antonenko, {Anna K.} and Kolosova, {Nataliya G.}",

note = "Funding Information: Funding: This research was funded by the Russian Science Foundation, grant number 21-15-00047. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = jul,

day = "2",

doi = "10.3390/ijms22147373",

language = "English",

volume = "22",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "14",