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Expression pattern and alternative splicing of HTT gene in human tissues. / Malakhova, A. A.; Elisaphenko, E. A.

In: Genes and Cells, Vol. 12, No. 4, 01.01.2017, p. 26-32.

Research output: Contribution to journal › Article › peer-review

Harvard

Malakhova, AA & Elisaphenko, EA 2017, 'Expression pattern and alternative splicing of HTT gene in human tissues', Genes and Cells, vol. 12, no. 4, pp. 26-32. https://doi.org/10.23868/201707026

APA

Malakhova, A. A., & Elisaphenko, E. A. (2017). Expression pattern and alternative splicing of HTT gene in human tissues. Genes and Cells, 12(4), 26-32. https://doi.org/10.23868/201707026

Vancouver

Malakhova AA, Elisaphenko EA. Expression pattern and alternative splicing of HTT gene in human tissues. Genes and Cells. 2017 Jan 1;12(4):26-32. doi: 10.23868/201707026

Author

Malakhova, A. A. ; Elisaphenko, E. A. / Expression pattern and alternative splicing of HTT gene in human tissues. In: Genes and Cells. 2017 ; Vol. 12, No. 4. pp. 26-32.

BibTeX

@article{7ed1d895e7344962aa539d2f8a61e951,
title = "Expression pattern and alternative splicing of HTT gene in human tissues",
abstract = "The HTT gene (Huntingtin, IT-15) was described in 1993 as highly expressed in various parts of the brain and other human and rodent tissues. The interest to this gene is due to the fact that the expansion of trinucleotide repeats in the first exon leads to the Huntington{\textquoteright}s disease. However, the causes of selective death of striata neurons in the course of the disease development are still unknown. Studying the HTT expression pattern in different tissues allows us to understand the role of HTT isoforms in different human tissues and organs. We studied the expression and alternative splicing of HTT in different parts of the brain and other human tissues in healthy people and Huntington{\textquoteright}s disease patients. No aberrant HTT forms were found in striatal neurons. This confirms the important role of the HTT gene for this type of neurons.",
keywords = "Alternative splicing, HTT gene, Striatal neurons",
author = "Malakhova, {A. A.} and Elisaphenko, {E. A.}",
year = "2017",
month = jan,
day = "1",
doi = "10.23868/201707026",
language = "English",
volume = "12",
pages = "26--32",
journal = "Genes and Cells",
issn = "2313-1829",
publisher = "Human Stem Cells Institute OJSC (HSCI)",
number = "4",

}

RIS

TY - JOUR

T1 - Expression pattern and alternative splicing of HTT gene in human tissues

AU - Malakhova, A. A.

AU - Elisaphenko, E. A.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - The HTT gene (Huntingtin, IT-15) was described in 1993 as highly expressed in various parts of the brain and other human and rodent tissues. The interest to this gene is due to the fact that the expansion of trinucleotide repeats in the first exon leads to the Huntington’s disease. However, the causes of selective death of striata neurons in the course of the disease development are still unknown. Studying the HTT expression pattern in different tissues allows us to understand the role of HTT isoforms in different human tissues and organs. We studied the expression and alternative splicing of HTT in different parts of the brain and other human tissues in healthy people and Huntington’s disease patients. No aberrant HTT forms were found in striatal neurons. This confirms the important role of the HTT gene for this type of neurons.

AB - The HTT gene (Huntingtin, IT-15) was described in 1993 as highly expressed in various parts of the brain and other human and rodent tissues. The interest to this gene is due to the fact that the expansion of trinucleotide repeats in the first exon leads to the Huntington’s disease. However, the causes of selective death of striata neurons in the course of the disease development are still unknown. Studying the HTT expression pattern in different tissues allows us to understand the role of HTT isoforms in different human tissues and organs. We studied the expression and alternative splicing of HTT in different parts of the brain and other human tissues in healthy people and Huntington’s disease patients. No aberrant HTT forms were found in striatal neurons. This confirms the important role of the HTT gene for this type of neurons.

KW - Alternative splicing

KW - HTT gene

KW - Striatal neurons

UR - http://www.scopus.com/inward/record.url?scp=85044571803&partnerID=8YFLogxK

U2 - 10.23868/201707026

DO - 10.23868/201707026

M3 - Article

AN - SCOPUS:85044571803

VL - 12

SP - 26

EP - 32

JO - Genes and Cells

JF - Genes and Cells

SN - 2313-1829

IS - 4

ER -

ID: 12300833