Elemental Boron-10 Nanoparticles Synthesized by Laser Fragmentation for Boron Neutron Capture Therapy: In Vitro Experiments. / Касатова, Анна Исмагиловна; Кузьмина, Ксения Сергеевна; Касатов, Дмитрий Александрович et al.
In: Bulletin of the Lebedev Physics Institute, Vol. 52, No. 2, 02.2025, p. 95-102.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Elemental Boron-10 Nanoparticles Synthesized by Laser Fragmentation for Boron Neutron Capture Therapy: In Vitro Experiments
AU - Касатова, Анна Исмагиловна
AU - Кузьмина, Ксения Сергеевна
AU - Касатов, Дмитрий Александрович
AU - Бармина, Екатерина Владимировна
AU - Айыыжы, Кудер Омакович
AU - Котельникова, Полина Александровна
AU - Григорьева, Мария Сергеевна
AU - Петруня, Дмитрий Сергеевич
AU - Завьялов, Евгений Леонидович
AU - Таскаев, Сергей Юрьевич
AU - Деев, Сергей Михайлович
AU - Завестовская, Ирина Николаевна
N1 - Elemental Boron-10 Nanoparticles Synthesized by Laser Fragmentation for Boron Neutron Capture Therapy: In Vitro Experiments / A. I. Kasatova, K. S. Kuzmina, D. A. Kasatov [et al.] // Bulletin of the Lebedev Physics Institute. – 2025. – Vol. 52. - No. 2. – P. 95-102. – DOI 10.3103/S1068335624602541. – EDN MGMBCG. The work was supported by the Russian Science Foundation (grant no. 24-62-00018, Advanced Combined Technologies of Neutron Capture Therapy Program).
PY - 2025/2
Y1 - 2025/2
N2 - Elemental boron-10 nanoparticles synthesized by laser fragmentation of micropowder in isopropanol are used for the first time as a boron-containing agent for boron neutron capture therapy. The study is conducted on human cell cultures U87, BT474, and BJ-5TA. It is found that these nanoparticles are nontoxic to all three cell cultures at boron-10 concentrations required for successful boron neutron capture therapy. The cell cultures are pre-incubated with nanoparticles and then irradiated for 30 min with a beam of epithermal neutrons generated by the VITA accelerator source (BINP SB RAS, Novosibirsk). Using in vitro study results (MTT assay and clonogenic analysis), an enhancement of the therapeutic effect of boron neutron capture therapy is observed.
AB - Elemental boron-10 nanoparticles synthesized by laser fragmentation of micropowder in isopropanol are used for the first time as a boron-containing agent for boron neutron capture therapy. The study is conducted on human cell cultures U87, BT474, and BJ-5TA. It is found that these nanoparticles are nontoxic to all three cell cultures at boron-10 concentrations required for successful boron neutron capture therapy. The cell cultures are pre-incubated with nanoparticles and then irradiated for 30 min with a beam of epithermal neutrons generated by the VITA accelerator source (BINP SB RAS, Novosibirsk). Using in vitro study results (MTT assay and clonogenic analysis), an enhancement of the therapeutic effect of boron neutron capture therapy is observed.
KW - BORON NEUTRON CAPTURE THERAPY
KW - ELEMENTAL BORON NANOPARTICLES
KW - LASER FRAGMENTATION
KW - CELL CULTURES
UR - https://elibrary.ru/item.asp?id=80616024
U2 - 10.3103/S1068335624602541
DO - 10.3103/S1068335624602541
M3 - Article
VL - 52
SP - 95
EP - 102
JO - Bulletin of the Lebedev Physics Institute
JF - Bulletin of the Lebedev Physics Institute
SN - 1068-3356
IS - 2
ER -
ID: 72826690