Dihydroartemisinin counteracts fibrotic portal hypertension via farnesoid X receptor-dependent inhibition of hepatic stellate cell contraction

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	114-133
Number of pages	20
Journal	FEBS Journal
Volume	284
Issue number	1
DOIs	https://doi.org/10.1111/febs.13956
Publication status	Published - 1 Jan 2017
Event	42nd Congress of the Federation-of-European-Biochemical-Societies (FEBS) on From Molecules to Cells and Back - Jerusalem, Israel Duration: 10 Sept 2017 → 14 Sept 2017

contraction, dihydroartemisinin, farnesoid X receptor, hepatic stellate cell, portal hypertension, Portal Vein/drug effects, Carbon Tetrachloride, Humans, Male, Cell Death/drug effects, Gene Expression, Liver/blood supply, Rats, Hepatocytes/drug effects, Mice, Transgenic, Chenodeoxycholic Acid/analogs & derivatives, Protective Agents/pharmacology, Rats, Sprague-Dawley, Mice, Inbred ICR, Receptors, Cytoplasmic and Nuclear/agonists, Liver Cirrhosis/chemically induced, Hypertension, Portal/chemically induced, Animals, Hepatic Stellate Cells/drug effects, Mice, Pregnenediones/pharmacology, Artemisinins/pharmacology

ID: 18734398