Research output: Contribution to journal › Article › peer-review
Determination of boron by inductively coupled plasma atomic emission spectroscopy. Biodistribution of 10B in tumor-bearing mice. / Tsygankova, A. R.; Kanygin, V. V.; Kasatova, A. I. et al.
In: Russian Chemical Bulletin, Vol. 69, No. 3, 01.03.2020, p. 601-607.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Determination of boron by inductively coupled plasma atomic emission spectroscopy. Biodistribution of 10B in tumor-bearing mice
AU - Tsygankova, A. R.
AU - Kanygin, V. V.
AU - Kasatova, A. I.
AU - Zav’yalov, E. L.
AU - Gusel’nikova, T. Ya
AU - Kichigin, A. I.
AU - Mukhamadiyarov, R. A.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - The determination of boron in animal organ tissues using inductively coupled plasma atomic emission spectroscopy (ICP AES) has been optimized for analytical support of boron neutron capture therapy of cancerous tumors. The proposed technique is universal and rapid. The methodology includes: preliminary acid decomposition at elevated temperatures and pressure (if necessary), determination of boron by ICP AES in the obtained solutions using reference samples based on single-element solutions. The method is verified by spike experiment and varying the weight-samples. The ICP AES technique was used to evaluate the accumulation of boronophenylalanine and borocaptate in mice organs. Biodistribution of 10B in the case of intravenous administration of the drug to SCID mice with SPF status using the human glioblastoma cell line U87 was investigated.
AB - The determination of boron in animal organ tissues using inductively coupled plasma atomic emission spectroscopy (ICP AES) has been optimized for analytical support of boron neutron capture therapy of cancerous tumors. The proposed technique is universal and rapid. The methodology includes: preliminary acid decomposition at elevated temperatures and pressure (if necessary), determination of boron by ICP AES in the obtained solutions using reference samples based on single-element solutions. The method is verified by spike experiment and varying the weight-samples. The ICP AES technique was used to evaluate the accumulation of boronophenylalanine and borocaptate in mice organs. Biodistribution of 10B in the case of intravenous administration of the drug to SCID mice with SPF status using the human glioblastoma cell line U87 was investigated.
KW - atomic emission spectroscopy
KW - borocaptate
KW - boron neutron capture therapy
KW - boronophenylalanine
KW - determination of boron
KW - organ tissue
KW - sample preparation
KW - BNCT
KW - DELIVERY
KW - P-BORONOPHENYLALANINE
KW - MICROWAVE DIGESTION
KW - BSH
KW - NEUTRON-CAPTURE THERAPY
KW - MASS SPECTROMETRY
KW - AGENTS
KW - NEBULIZATION
UR - http://www.scopus.com/inward/record.url?scp=85083345299&partnerID=8YFLogxK
U2 - 10.1007/s11172-020-2805-8
DO - 10.1007/s11172-020-2805-8
M3 - Article
AN - SCOPUS:85083345299
VL - 69
SP - 601
EP - 607
JO - Russian Chemical Bulletin
JF - Russian Chemical Bulletin
SN - 1066-5285
IS - 3
ER -
ID: 24159783