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Degradation of core-shell Au@SiO2 nanoparticles in biological media. / Ryabchikova, Elena I.; Chelobanov, Boris P.; Parkhomenko, Roman G. et al.

In: Microporous and Mesoporous Materials, Vol. 248, 08.2017, p. 46-53.

Research output: Contribution to journal › Article › peer-review

Harvard

Ryabchikova, EI, Chelobanov, BP, Parkhomenko, RG, Korchagina, KV & Basova, TV 2017, 'Degradation of core-shell Au@SiO2 nanoparticles in biological media', Microporous and Mesoporous Materials, vol. 248, pp. 46-53. https://doi.org/10.1016/j.micromeso.2017.04.006

APA

Ryabchikova, E. I., Chelobanov, B. P., Parkhomenko, R. G., Korchagina, K. V., & Basova, T. V. (2017). Degradation of core-shell Au@SiO2 nanoparticles in biological media. Microporous and Mesoporous Materials, 248, 46-53. https://doi.org/10.1016/j.micromeso.2017.04.006

Vancouver

Ryabchikova EI, Chelobanov BP, Parkhomenko RG, Korchagina KV, Basova TV. Degradation of core-shell Au@SiO2 nanoparticles in biological media. Microporous and Mesoporous Materials. 2017 Aug;248:46-53. doi: 10.1016/j.micromeso.2017.04.006

Author

Ryabchikova, Elena I. ; Chelobanov, Boris P. ; Parkhomenko, Roman G. et al. / Degradation of core-shell Au@SiO2 nanoparticles in biological media. In: Microporous and Mesoporous Materials. 2017 ; Vol. 248. pp. 46-53.

BibTeX

@article{14601965063d4fb48e207900d7770fdf,
title = "Degradation of core-shell Au@SiO2 nanoparticles in biological media",
abstract = "In this work, the effect of a cell culture medium on the integrity of mesoporous silica shell of gold-core nanoparticles (Au@SiO2 NPs) and their behavior in cells of HeLa, MDA-MB and BT cultures were studied using the method of transmission electron microscopy. It was shown that degradation of Au@SiO2 NPs takes place in the culture medium. The presence of the cells and serum does not influence on the process of the mesoporous silica layer degradation. The presence of both damaged and undamaged NPs in endosomes and lysosomes is related to different time of NPs{\textquoteright} location outside of the cell, i.e. in culture medium. The analysis of the cell ultrastructure leads to a conclusion that the internal conditions in endosomes/lysosomes do not influence on the integrity of Au@SiO2 NPs.",
keywords = "Eukaryotic cells, Gold core–mesoporous silica shell nanoparticles, Mesoporous silica, Transmission electron microscopy, GOLD NANOPARTICLES, DRUG-DELIVERY, BEHAVIOR, SURFACE CHARACTERISTICS, Gold core-mesoporous silica shell nanoparticles, MESOPOROUS SILICA NANOPARTICLES, NANORODS, CANCER-THERAPY, GROWTH, PLASMON RESONANCE, GEOMETRY",
author = "Ryabchikova, {Elena I.} and Chelobanov, {Boris P.} and Parkhomenko, {Roman G.} and Korchagina, {Kseniya V.} and Basova, {Tamara V.}",
year = "2017",
month = aug,
doi = "10.1016/j.micromeso.2017.04.006",
language = "English",
volume = "248",
pages = "46--53",
journal = "Microporous and Mesoporous Materials",
issn = "1387-1811",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Degradation of core-shell Au@SiO2 nanoparticles in biological media

AU - Ryabchikova, Elena I.

AU - Chelobanov, Boris P.

AU - Parkhomenko, Roman G.

AU - Korchagina, Kseniya V.

AU - Basova, Tamara V.

PY - 2017/8

Y1 - 2017/8

N2 - In this work, the effect of a cell culture medium on the integrity of mesoporous silica shell of gold-core nanoparticles (Au@SiO2 NPs) and their behavior in cells of HeLa, MDA-MB and BT cultures were studied using the method of transmission electron microscopy. It was shown that degradation of Au@SiO2 NPs takes place in the culture medium. The presence of the cells and serum does not influence on the process of the mesoporous silica layer degradation. The presence of both damaged and undamaged NPs in endosomes and lysosomes is related to different time of NPs’ location outside of the cell, i.e. in culture medium. The analysis of the cell ultrastructure leads to a conclusion that the internal conditions in endosomes/lysosomes do not influence on the integrity of Au@SiO2 NPs.

AB - In this work, the effect of a cell culture medium on the integrity of mesoporous silica shell of gold-core nanoparticles (Au@SiO2 NPs) and their behavior in cells of HeLa, MDA-MB and BT cultures were studied using the method of transmission electron microscopy. It was shown that degradation of Au@SiO2 NPs takes place in the culture medium. The presence of the cells and serum does not influence on the process of the mesoporous silica layer degradation. The presence of both damaged and undamaged NPs in endosomes and lysosomes is related to different time of NPs’ location outside of the cell, i.e. in culture medium. The analysis of the cell ultrastructure leads to a conclusion that the internal conditions in endosomes/lysosomes do not influence on the integrity of Au@SiO2 NPs.

KW - Eukaryotic cells

KW - Gold core–mesoporous silica shell nanoparticles

KW - Mesoporous silica

KW - Transmission electron microscopy

KW - GOLD NANOPARTICLES

KW - DRUG-DELIVERY

KW - BEHAVIOR

KW - SURFACE CHARACTERISTICS

KW - Gold core-mesoporous silica shell nanoparticles

KW - MESOPOROUS SILICA NANOPARTICLES

KW - NANORODS

KW - CANCER-THERAPY

KW - GROWTH

KW - PLASMON RESONANCE

KW - GEOMETRY

UR - http://www.scopus.com/inward/record.url?scp=85017422890&partnerID=8YFLogxK

U2 - 10.1016/j.micromeso.2017.04.006

DO - 10.1016/j.micromeso.2017.04.006

M3 - Article

AN - SCOPUS:85017422890

VL - 248

SP - 46

EP - 53

JO - Microporous and Mesoporous Materials

JF - Microporous and Mesoporous Materials

SN - 1387-1811

ER -

ID: 10264120