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Decomposing the genetic background of chronic back pain. / Elgaeva, Elizaveta E.; Zorkoltseva, Irina V.; Nostaeva, Arina V. et al.

In: Human Molecular Genetics, Vol. 34, No. 8, 15.04.2025, p. 711-725.

Research output: Contribution to journal › Article › peer-review

Harvard

Elgaeva, EE, Zorkoltseva, IV, Nostaeva, AV, Verzun, DA, Tiys, ES, Timoshchuk, AN, Kirichenko, AV, Svishcheva, GR, Freidin, MB, Williams, FMK, Suri, P, Aulchenko, YS, Axenovich, TI & Tsepilov, YA 2025, 'Decomposing the genetic background of chronic back pain', Human Molecular Genetics, vol. 34, no. 8, pp. 711-725. https://doi.org/10.1093/hmg/ddae195

APA

Elgaeva, E. E., Zorkoltseva, I. V., Nostaeva, A. V., Verzun, D. A., Tiys, E. S., Timoshchuk, A. N., Kirichenko, A. V., Svishcheva, G. R., Freidin, M. B., Williams, F. M. K., Suri, P., Aulchenko, Y. S., Axenovich, T. I., & Tsepilov, Y. A. (2025). Decomposing the genetic background of chronic back pain. Human Molecular Genetics, 34(8), 711-725. https://doi.org/10.1093/hmg/ddae195

Vancouver

Elgaeva EE, Zorkoltseva IV, Nostaeva AV, Verzun DA, Tiys ES, Timoshchuk AN et al. Decomposing the genetic background of chronic back pain. Human Molecular Genetics. 2025 Apr 15;34(8):711-725. doi: 10.1093/hmg/ddae195

Author

Elgaeva, Elizaveta E. ; Zorkoltseva, Irina V. ; Nostaeva, Arina V. et al. / Decomposing the genetic background of chronic back pain. In: Human Molecular Genetics. 2025 ; Vol. 34, No. 8. pp. 711-725.

BibTeX

@article{09323adf978f4a8988fa54a59ccb320e,
title = "Decomposing the genetic background of chronic back pain",
abstract = "Chronic back pain (CBP) is a disabling condition with a lifetime prevalence of 40% and a substantial socioeconomic burden. Because of the high heterogeneity of CBP, subphenotyping may help to improve prediction and support personalized treatment of CBP. To investigate CBP subphenotypes, we decomposed its genetic background into a shared one common to other chronic pain conditions (back, neck, hip, knee, stomach, and head pain) and unshared genetic background specific to CBP. We identified and replicated 18 genes with shared impact across different chronic pain conditions and two genes that were specific for CBP. Among people with CBP, we demonstrated that polygenic risk scores accounting for the shared and unshared genetic backgrounds of CBP may underpin different CBP subphenotypes. These subphenotypes are characterized by varying genetic predisposition to diverse medical conditions and interventions such as diabetes mellitus, myocardial infarction, diagnostic endoscopic procedures, and surgery involving muscles, bones, and joints.",
keywords = "genome-wide association study, low back pain, polygenic risk score, shared genetic background, subphenotyping",
author = "Elgaeva, {Elizaveta E.} and Zorkoltseva, {Irina V.} and Nostaeva, {Arina V.} and Verzun, {Dmitrii A.} and Tiys, {Evgeny S.} and Timoshchuk, {Anna N.} and Kirichenko, {Anatoliy V.} and Svishcheva, {Gulnara R.} and Freidin, {Maxim B.} and Williams, {Frances M.K.} and Pradeep Suri and Aulchenko, {Yurii S.} and Axenovich, {Tatiana I.} and Tsepilov, {Yakov A.}",
year = "2025",
month = apr,
day = "15",
doi = "10.1093/hmg/ddae195",
language = "English",
volume = "34",
pages = "711--725",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "8",

}

RIS

TY - JOUR

T1 - Decomposing the genetic background of chronic back pain

AU - Elgaeva, Elizaveta E.

AU - Zorkoltseva, Irina V.

AU - Nostaeva, Arina V.

AU - Verzun, Dmitrii A.

AU - Tiys, Evgeny S.

AU - Timoshchuk, Anna N.

AU - Kirichenko, Anatoliy V.

AU - Svishcheva, Gulnara R.

AU - Freidin, Maxim B.

AU - Williams, Frances M.K.

AU - Suri, Pradeep

AU - Aulchenko, Yurii S.

AU - Axenovich, Tatiana I.

AU - Tsepilov, Yakov A.

PY - 2025/4/15

Y1 - 2025/4/15

N2 - Chronic back pain (CBP) is a disabling condition with a lifetime prevalence of 40% and a substantial socioeconomic burden. Because of the high heterogeneity of CBP, subphenotyping may help to improve prediction and support personalized treatment of CBP. To investigate CBP subphenotypes, we decomposed its genetic background into a shared one common to other chronic pain conditions (back, neck, hip, knee, stomach, and head pain) and unshared genetic background specific to CBP. We identified and replicated 18 genes with shared impact across different chronic pain conditions and two genes that were specific for CBP. Among people with CBP, we demonstrated that polygenic risk scores accounting for the shared and unshared genetic backgrounds of CBP may underpin different CBP subphenotypes. These subphenotypes are characterized by varying genetic predisposition to diverse medical conditions and interventions such as diabetes mellitus, myocardial infarction, diagnostic endoscopic procedures, and surgery involving muscles, bones, and joints.

AB - Chronic back pain (CBP) is a disabling condition with a lifetime prevalence of 40% and a substantial socioeconomic burden. Because of the high heterogeneity of CBP, subphenotyping may help to improve prediction and support personalized treatment of CBP. To investigate CBP subphenotypes, we decomposed its genetic background into a shared one common to other chronic pain conditions (back, neck, hip, knee, stomach, and head pain) and unshared genetic background specific to CBP. We identified and replicated 18 genes with shared impact across different chronic pain conditions and two genes that were specific for CBP. Among people with CBP, we demonstrated that polygenic risk scores accounting for the shared and unshared genetic backgrounds of CBP may underpin different CBP subphenotypes. These subphenotypes are characterized by varying genetic predisposition to diverse medical conditions and interventions such as diabetes mellitus, myocardial infarction, diagnostic endoscopic procedures, and surgery involving muscles, bones, and joints.

KW - genome-wide association study

KW - low back pain

KW - polygenic risk score

KW - shared genetic background

KW - subphenotyping

UR - https://www.mendeley.com/catalogue/e1cd6813-8bf8-3126-a25b-ccc08705ea63/

UR - https://pubmed.ncbi.nlm.nih.gov/39895344/

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-105002226476&origin=inward&txGid=87c5790968b237951e7e9aa1553e177d

U2 - 10.1093/hmg/ddae195

DO - 10.1093/hmg/ddae195

M3 - Article

C2 - 39895344

VL - 34

SP - 711

EP - 725

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 8

ER -

ID: 65201029