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Cytotoxicity and Crystal Structures of Nitrosoruthenium Complexes mer-[Ru(NO)Py2Cl3] and mer-[Ru(NO)(γ-Pic)2Cl3]. / Makhinya, Alexander N.; Eremina, Julia A.; Sukhikh, Taisiya S. et al.

In: ChemistrySelect, Vol. 4, No. 19, 24.05.2019, p. 5866-5871.

Research output: Contribution to journal › Article › peer-review

Harvard

Makhinya, AN, Eremina, JA, Sukhikh, TS, Baidina, IA, Il'in, MA, Klyushova, LS & Lider, EV 2019, 'Cytotoxicity and Crystal Structures of Nitrosoruthenium Complexes mer-[Ru(NO)Py2Cl3] and mer-[Ru(NO)(γ-Pic)2Cl3]', ChemistrySelect, vol. 4, no. 19, pp. 5866-5871. https://doi.org/10.1002/slct.201900111

APA

Makhinya, A. N., Eremina, J. A., Sukhikh, T. S., Baidina, I. A., Il'in, M. A., Klyushova, L. S., & Lider, E. V. (2019). Cytotoxicity and Crystal Structures of Nitrosoruthenium Complexes mer-[Ru(NO)Py2Cl3] and mer-[Ru(NO)(γ-Pic)2Cl3]. ChemistrySelect, 4(19), 5866-5871. https://doi.org/10.1002/slct.201900111

Vancouver

Makhinya AN, Eremina JA, Sukhikh TS, Baidina IA, Il'in MA, Klyushova LS et al. Cytotoxicity and Crystal Structures of Nitrosoruthenium Complexes mer-[Ru(NO)Py2Cl3] and mer-[Ru(NO)(γ-Pic)2Cl3]. ChemistrySelect. 2019 May 24;4(19):5866-5871. doi: 10.1002/slct.201900111

Author

Makhinya, Alexander N. ; Eremina, Julia A. ; Sukhikh, Taisiya S. et al. / Cytotoxicity and Crystal Structures of Nitrosoruthenium Complexes mer-[Ru(NO)Py2Cl3] and mer-[Ru(NO)(γ-Pic)2Cl3]. In: ChemistrySelect. 2019 ; Vol. 4, No. 19. pp. 5866-5871.

BibTeX

@article{4a7167d1032b48f0b0be41560d1173cf,
title = "Cytotoxicity and Crystal Structures of Nitrosoruthenium Complexes mer-[Ru(NO)Py2Cl3] and mer-[Ru(NO)(γ-Pic)2Cl3]",
abstract = "The reaction of K2[Ru(NO)Cl5] with excess of pyridine or γ-picoline in DMF solution at high temperature gives mer-[Ru(NO)Py2Cl3] (I) and mer-[Ru(NO)(γ-Pic)2Cl3] (II), correspondingly, that were obtained with high yields (∼80%) by filtration of concentrated solutions. There is another method for this synthesis that consists of reaction of the same salt with respective heterocycle in water solution with following evaporation with ethanol addition (yield is ∼95%). The crystal structures of the compounds were determined by X-ray single-crystal diffraction analysis. Synthesized compounds were characterized by elemental analysis, TGA, IR- and NMR-spectroscopy. The title complexes and related compounds fac-[Ru(NO)Py2Cl3] (III), cis-[Ru(NO)Py2Cl2(OH)] (IV), trans-[Ru(NO)Py2Cl2(OH)] (V), trans-[Ru(NO)Py4(OH)]Cl2⋅H2O (VI), trans-[Ru(NO)Py4Cl]Cl2⋅H2O (VII) were examined on cytotoxic activity towards Hep-2 cancer cell line and HEK-293 cell line. All the complexes have shown a dose-dependent cytotoxic effect, complex II has the lowest IC50 value.",
keywords = "cytotoxic activity, pyridine, ruthenium nitrosyl complexes, γ-picoline, 2,2'-BIPYRIDINE, NO, HYDROXO, ACID, RELEASE, gamma-picoline, LIGANDS, RUTHENIUM COMPLEXES, NITRIC-OXIDE, TRANSFORMATIONS",
author = "Makhinya, {Alexander N.} and Eremina, {Julia A.} and Sukhikh, {Taisiya S.} and Baidina, {Iraida A.} and Il'in, {Maxim A.} and Klyushova, {Lyubov S.} and Lider, {Elizaveta V.}",
year = "2019",
month = may,
day = "24",
doi = "10.1002/slct.201900111",
language = "English",
volume = "4",
pages = "5866--5871",
journal = "ChemistrySelect",
issn = "2365-6549",
publisher = "Wiley-Blackwell",
number = "19",

}

RIS

TY - JOUR

T1 - Cytotoxicity and Crystal Structures of Nitrosoruthenium Complexes mer-[Ru(NO)Py2Cl3] and mer-[Ru(NO)(γ-Pic)2Cl3]

AU - Makhinya, Alexander N.

AU - Eremina, Julia A.

AU - Sukhikh, Taisiya S.

AU - Baidina, Iraida A.

AU - Il'in, Maxim A.

AU - Klyushova, Lyubov S.

AU - Lider, Elizaveta V.

PY - 2019/5/24

Y1 - 2019/5/24

N2 - The reaction of K2[Ru(NO)Cl5] with excess of pyridine or γ-picoline in DMF solution at high temperature gives mer-[Ru(NO)Py2Cl3] (I) and mer-[Ru(NO)(γ-Pic)2Cl3] (II), correspondingly, that were obtained with high yields (∼80%) by filtration of concentrated solutions. There is another method for this synthesis that consists of reaction of the same salt with respective heterocycle in water solution with following evaporation with ethanol addition (yield is ∼95%). The crystal structures of the compounds were determined by X-ray single-crystal diffraction analysis. Synthesized compounds were characterized by elemental analysis, TGA, IR- and NMR-spectroscopy. The title complexes and related compounds fac-[Ru(NO)Py2Cl3] (III), cis-[Ru(NO)Py2Cl2(OH)] (IV), trans-[Ru(NO)Py2Cl2(OH)] (V), trans-[Ru(NO)Py4(OH)]Cl2⋅H2O (VI), trans-[Ru(NO)Py4Cl]Cl2⋅H2O (VII) were examined on cytotoxic activity towards Hep-2 cancer cell line and HEK-293 cell line. All the complexes have shown a dose-dependent cytotoxic effect, complex II has the lowest IC50 value.

AB - The reaction of K2[Ru(NO)Cl5] with excess of pyridine or γ-picoline in DMF solution at high temperature gives mer-[Ru(NO)Py2Cl3] (I) and mer-[Ru(NO)(γ-Pic)2Cl3] (II), correspondingly, that were obtained with high yields (∼80%) by filtration of concentrated solutions. There is another method for this synthesis that consists of reaction of the same salt with respective heterocycle in water solution with following evaporation with ethanol addition (yield is ∼95%). The crystal structures of the compounds were determined by X-ray single-crystal diffraction analysis. Synthesized compounds were characterized by elemental analysis, TGA, IR- and NMR-spectroscopy. The title complexes and related compounds fac-[Ru(NO)Py2Cl3] (III), cis-[Ru(NO)Py2Cl2(OH)] (IV), trans-[Ru(NO)Py2Cl2(OH)] (V), trans-[Ru(NO)Py4(OH)]Cl2⋅H2O (VI), trans-[Ru(NO)Py4Cl]Cl2⋅H2O (VII) were examined on cytotoxic activity towards Hep-2 cancer cell line and HEK-293 cell line. All the complexes have shown a dose-dependent cytotoxic effect, complex II has the lowest IC50 value.

KW - cytotoxic activity

KW - pyridine

KW - ruthenium nitrosyl complexes

KW - γ-picoline

KW - 2,2'-BIPYRIDINE

KW - NO

KW - HYDROXO

KW - ACID

KW - RELEASE

KW - gamma-picoline

KW - LIGANDS

KW - RUTHENIUM COMPLEXES

KW - NITRIC-OXIDE

KW - TRANSFORMATIONS

UR - http://www.scopus.com/inward/record.url?scp=85066234311&partnerID=8YFLogxK

U2 - 10.1002/slct.201900111

DO - 10.1002/slct.201900111

M3 - Article

AN - SCOPUS:85066234311

VL - 4

SP - 5866

EP - 5871

JO - ChemistrySelect

JF - ChemistrySelect

SN - 2365-6549

IS - 19

ER -

ID: 20344562