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Comprehensive study of hexarhenium cluster complex Na4[{Re6Te8}(CN)6] – In terms of a new promising luminescent and X-ray contrast agent. / Krasilnikova, Anna A.; Solovieva, Anastasiya O.; Ivanov, Anton A. et al.

In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 13, No. 2, 01.02.2017, p. 755-763.

Research output: Contribution to journal › Article › peer-review

Harvard

Krasilnikova, AA, Solovieva, AO, Ivanov, AA, Trifonova, KE, Pozmogova, TN, Tsygankova, AR, Smolentsev, AI, Kretov, EI, Sergeevichev, DS, Shestopalov, MA, Mironov, YV, Shestopalov, AM, Poveshchenko, AF & Shestopalova, LV 2017, 'Comprehensive study of hexarhenium cluster complex Na4[{Re6Te8}(CN)6] – In terms of a new promising luminescent and X-ray contrast agent', Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 13, no. 2, pp. 755-763. https://doi.org/10.1016/j.nano.2016.10.016

APA

Krasilnikova, A. A., Solovieva, A. O., Ivanov, A. A., Trifonova, K. E., Pozmogova, T. N., Tsygankova, A. R., Smolentsev, A. I., Kretov, E. I., Sergeevichev, D. S., Shestopalov, M. A., Mironov, Y. V., Shestopalov, A. M., Poveshchenko, A. F., & Shestopalova, L. V. (2017). Comprehensive study of hexarhenium cluster complex Na4[{Re6Te8}(CN)6] – In terms of a new promising luminescent and X-ray contrast agent. Nanomedicine: Nanotechnology, Biology, and Medicine, 13(2), 755-763. https://doi.org/10.1016/j.nano.2016.10.016

Vancouver

Krasilnikova AA, Solovieva AO, Ivanov AA, Trifonova KE, Pozmogova TN, Tsygankova AR et al. Comprehensive study of hexarhenium cluster complex Na4[{Re6Te8}(CN)6] – In terms of a new promising luminescent and X-ray contrast agent. Nanomedicine: Nanotechnology, Biology, and Medicine. 2017 Feb 1;13(2):755-763. doi: 10.1016/j.nano.2016.10.016

Author

Krasilnikova, Anna A. ; Solovieva, Anastasiya O. ; Ivanov, Anton A. et al. / Comprehensive study of hexarhenium cluster complex Na4[{Re6Te8}(CN)6] – In terms of a new promising luminescent and X-ray contrast agent. In: Nanomedicine: Nanotechnology, Biology, and Medicine. 2017 ; Vol. 13, No. 2. pp. 755-763.

BibTeX

@article{fd1a15999e1043e99d137961ee91ef08,
title = "Comprehensive study of hexarhenium cluster complex Na4[{Re6Te8}(CN)6] – In terms of a new promising luminescent and X-ray contrast agent",
abstract = "Octahedral rhenium cluster complexes may have considerable potential as therapeutic and diagnostic drugs due to their luminescent and X-ray contrast properties, as well as their ability to generate singlet oxygen upon photoirradiation. However, their potential biological effects and toxicity in vitro and in vivo are rather far from being understood. Thus, the aim of our research was to study cytotoxicity, intracellular localization and cellular uptake/elimination kinetics in vitro, biodistribution and acute intravenous toxicity in vivo of a complex Na4[{Re6Te8}(CN)6] as the promising compound for biomedical application. The results have demonstrated that the complex penetrates through cell membranes with the maximum accumulation in cells in 24 h of incubation and have low toxic effects in vitro and in vivo. The median lethal dose (LD50) of intravenously administrated Na4[{Re6Te8}(CN)6] is equal to 1082 ± 83 mg/kg. These findings will be useful for future development of cluster-based agents for different biomedical applications.",
keywords = "Acute intravenous toxicity, Angiography, Intracellular localization, Tellurocyanide octahedral rhenium cluster complex, X-ray contrast agent, Tissue Distribution, Contrast Media, X-Rays, Humans, Luminescence, Rhenium, Tumor Cells, Cultured, PHOTODYNAMIC THERAPY, PHOTOSENSITIZERS, CANCER",
author = "Krasilnikova, {Anna A.} and Solovieva, {Anastasiya O.} and Ivanov, {Anton A.} and Trifonova, {Kristina E.} and Pozmogova, {Tatiana N.} and Tsygankova, {Alphiya R.} and Smolentsev, {Anton I.} and Kretov, {Evgeniy I.} and Sergeevichev, {David S.} and Shestopalov, {Michael A.} and Mironov, {Yuri V.} and Shestopalov, {Alexander M.} and Poveshchenko, {Alexander F.} and Shestopalova, {Lidiya V.}",
note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",
year = "2017",
month = feb,
day = "1",
doi = "10.1016/j.nano.2016.10.016",
language = "English",
volume = "13",
pages = "755--763",
journal = "Nanomedicine: Nanotechnology, Biology, and Medicine",
issn = "1549-9634",
publisher = "Elsevier Science Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Comprehensive study of hexarhenium cluster complex Na4[{Re6Te8}(CN)6] – In terms of a new promising luminescent and X-ray contrast agent

AU - Krasilnikova, Anna A.

AU - Solovieva, Anastasiya O.

AU - Ivanov, Anton A.

AU - Trifonova, Kristina E.

AU - Pozmogova, Tatiana N.

AU - Tsygankova, Alphiya R.

AU - Smolentsev, Anton I.

AU - Kretov, Evgeniy I.

AU - Sergeevichev, David S.

AU - Shestopalov, Michael A.

AU - Mironov, Yuri V.

AU - Shestopalov, Alexander M.

AU - Poveshchenko, Alexander F.

AU - Shestopalova, Lidiya V.

N1 - Publisher Copyright: © 2016 Elsevier Inc.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Octahedral rhenium cluster complexes may have considerable potential as therapeutic and diagnostic drugs due to their luminescent and X-ray contrast properties, as well as their ability to generate singlet oxygen upon photoirradiation. However, their potential biological effects and toxicity in vitro and in vivo are rather far from being understood. Thus, the aim of our research was to study cytotoxicity, intracellular localization and cellular uptake/elimination kinetics in vitro, biodistribution and acute intravenous toxicity in vivo of a complex Na4[{Re6Te8}(CN)6] as the promising compound for biomedical application. The results have demonstrated that the complex penetrates through cell membranes with the maximum accumulation in cells in 24 h of incubation and have low toxic effects in vitro and in vivo. The median lethal dose (LD50) of intravenously administrated Na4[{Re6Te8}(CN)6] is equal to 1082 ± 83 mg/kg. These findings will be useful for future development of cluster-based agents for different biomedical applications.

AB - Octahedral rhenium cluster complexes may have considerable potential as therapeutic and diagnostic drugs due to their luminescent and X-ray contrast properties, as well as their ability to generate singlet oxygen upon photoirradiation. However, their potential biological effects and toxicity in vitro and in vivo are rather far from being understood. Thus, the aim of our research was to study cytotoxicity, intracellular localization and cellular uptake/elimination kinetics in vitro, biodistribution and acute intravenous toxicity in vivo of a complex Na4[{Re6Te8}(CN)6] as the promising compound for biomedical application. The results have demonstrated that the complex penetrates through cell membranes with the maximum accumulation in cells in 24 h of incubation and have low toxic effects in vitro and in vivo. The median lethal dose (LD50) of intravenously administrated Na4[{Re6Te8}(CN)6] is equal to 1082 ± 83 mg/kg. These findings will be useful for future development of cluster-based agents for different biomedical applications.

KW - Acute intravenous toxicity

KW - Angiography

KW - Intracellular localization

KW - Tellurocyanide octahedral rhenium cluster complex

KW - X-ray contrast agent

KW - Tissue Distribution

KW - Contrast Media

KW - X-Rays

KW - Humans

KW - Luminescence

KW - Rhenium

KW - Tumor Cells, Cultured

KW - PHOTODYNAMIC THERAPY

KW - PHOTOSENSITIZERS

KW - CANCER

UR - http://www.scopus.com/inward/record.url?scp=85010796735&partnerID=8YFLogxK

U2 - 10.1016/j.nano.2016.10.016

DO - 10.1016/j.nano.2016.10.016

M3 - Article

C2 - 27816527

AN - SCOPUS:85010796735

VL - 13

SP - 755

EP - 763

JO - Nanomedicine: Nanotechnology, Biology, and Medicine

JF - Nanomedicine: Nanotechnology, Biology, and Medicine

SN - 1549-9634

IS - 2

ER -

ID: 9029550