Co-expression of membrane-bound TNF-alpha type 1 and 2 receptors differ in the subsets of immunocompetent cells. / Sennikov, Sergey; Alshevskaya, Alina; Zhukova, Julia et al.
In: Immunology Letters, Vol. 207, 01.03.2019, p. 1-5.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Co-expression of membrane-bound TNF-alpha type 1 and 2 receptors differ in the subsets of immunocompetent cells
AU - Sennikov, Sergey
AU - Alshevskaya, Alina
AU - Zhukova, Julia
AU - Belomestnova, Irina
AU - Karaulov, Aleksander
AU - Evsegneeva, Irina
AU - Lopatnikova, Julia
N1 - Copyright © 2019 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - The immunoregulatory cytokine tumor necrosis factor α plays crucial roles in the pathogenesis of a broad spectrum of disorders. However, its effect may depend on the expression and co-expression of receptors on the target cell. The aim of the present study was to evaluate the expression levels of type 1 and 2 tumor necrosis factor α receptors (TNFR1/2) on individual cell subsets from peripheral blood of healthy volunteers. Flow cytometry analysis was used to study whole populations as well as subsets (T regulatory cells, T memory cells, cytotoxic T cells, T helper cells). Significant differences in the co-expression of TNFR1/2 were seen within subsets and total pools. Further studies are necessary to explore the implications of the observed differences in the modulation of tumor necrosis factor α function in health and pathology.
AB - The immunoregulatory cytokine tumor necrosis factor α plays crucial roles in the pathogenesis of a broad spectrum of disorders. However, its effect may depend on the expression and co-expression of receptors on the target cell. The aim of the present study was to evaluate the expression levels of type 1 and 2 tumor necrosis factor α receptors (TNFR1/2) on individual cell subsets from peripheral blood of healthy volunteers. Flow cytometry analysis was used to study whole populations as well as subsets (T regulatory cells, T memory cells, cytotoxic T cells, T helper cells). Significant differences in the co-expression of TNFR1/2 were seen within subsets and total pools. Further studies are necessary to explore the implications of the observed differences in the modulation of tumor necrosis factor α function in health and pathology.
KW - Cellular immunology
KW - Cytokine receptors expression
KW - Immune regulation
KW - EXPRESSION
UR - http://www.scopus.com/inward/record.url?scp=85060220346&partnerID=8YFLogxK
U2 - 10.1016/j.imlet.2019.01.005
DO - 10.1016/j.imlet.2019.01.005
M3 - Article
C2 - 30639514
AN - SCOPUS:85060220346
VL - 207
SP - 1
EP - 5
JO - Immunology Letters
JF - Immunology Letters
SN - 0165-2478
ER -
ID: 18296730