Research output: Contribution to journal › Article › peer-review
Chromosome synapsis and recombination in male hybrids between two chromosome races of the common shrew (Sorex araneus L., Soricidae, Eulipotyphla). / Belonogova, Nadezhda M.; Polyakov, Andrei V.; Karamysheva, Tatyana V. et al.
In: Genes, Vol. 8, No. 10, 282, 20.10.2017.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Chromosome synapsis and recombination in male hybrids between two chromosome races of the common shrew (Sorex araneus L., Soricidae, Eulipotyphla)
AU - Belonogova, Nadezhda M.
AU - Polyakov, Andrei V.
AU - Karamysheva, Tatyana V.
AU - Torgasheva, Anna A.
AU - Searle, Jeremy B.
AU - Borodin, Pavel M.
N1 - Publisher Copyright: © 2017 by the authors; Licensee MDPI, Basel, Switzerland.
PY - 2017/10/20
Y1 - 2017/10/20
N2 - Hybrid zones between chromosome races of the common shrew (Sorex araneus) provide exceptional models to study the potential role of chromosome rearrangements in the initial steps of speciation. The Novosibirsk and Tomsk races differ by a series of Robertsonian fusions with monobrachial homology. They form a narrow hybrid zone and generate hybrids with both simple (chain of three chromosomes) and complex (chain of eight or nine) synaptic configurations. Using immunolocalisation of the meiotic proteins, we examined chromosome pairing and recombination in males from the hybrid zone. Homozygotes and simple heterozygotes for Robertsonian fusions showed a low frequency of synaptic aberrations (<10%). The carriers of complex synaptic configurations showed multiple pairing abnormalities, which might lead to reduced fertility. The recombination frequency in the proximal regions of most chromosomes of all karyotypes was much lower than in the other regions. The strong suppression of recombination in the pericentromeric regions and co-segregation of race specific chromosomes involved in the long chains would be expected to lead to linkage disequilibrium between genes located there. Genic differentiation, together with the high frequency of pairing aberrations in male carriers of the long chains, might contribute to maintenance of the narrow hybrid zone.
AB - Hybrid zones between chromosome races of the common shrew (Sorex araneus) provide exceptional models to study the potential role of chromosome rearrangements in the initial steps of speciation. The Novosibirsk and Tomsk races differ by a series of Robertsonian fusions with monobrachial homology. They form a narrow hybrid zone and generate hybrids with both simple (chain of three chromosomes) and complex (chain of eight or nine) synaptic configurations. Using immunolocalisation of the meiotic proteins, we examined chromosome pairing and recombination in males from the hybrid zone. Homozygotes and simple heterozygotes for Robertsonian fusions showed a low frequency of synaptic aberrations (<10%). The carriers of complex synaptic configurations showed multiple pairing abnormalities, which might lead to reduced fertility. The recombination frequency in the proximal regions of most chromosomes of all karyotypes was much lower than in the other regions. The strong suppression of recombination in the pericentromeric regions and co-segregation of race specific chromosomes involved in the long chains would be expected to lead to linkage disequilibrium between genes located there. Genic differentiation, together with the high frequency of pairing aberrations in male carriers of the long chains, might contribute to maintenance of the narrow hybrid zone.
KW - Common shrew
KW - Hybrids
KW - Meiotic chromosomes
KW - MLH1
KW - Sorex araneus
KW - Synaptonemal complex
KW - PACHYTENE CHECKPOINT
KW - MONOBRACHIAL CENTRIC FUSIONS
KW - REDUCED GENE FLOW
KW - HOUSE MOUSE
KW - ZONE
KW - SIBERIA
KW - hybrids
KW - synaptonemal complex
KW - meiotic chromosomes
KW - SYNAPTONEMAL COMPLEXES
KW - common shrew
KW - KARYOTYPIC RACES
KW - SPECIATION
KW - MEIOSIS
UR - http://www.scopus.com/inward/record.url?scp=85032573857&partnerID=8YFLogxK
U2 - 10.3390/genes8100282
DO - 10.3390/genes8100282
M3 - Article
C2 - 29053571
AN - SCOPUS:85032573857
VL - 8
JO - Genes
JF - Genes
SN - 2073-4425
IS - 10
M1 - 282
ER -
ID: 8975320