Chemical Reaction Monitoring using Zero-Field Nuclear Magnetic Resonance Enables Study of Heterogeneous Samples in Metal Containers

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Chemical Reaction Monitoring using Zero-Field Nuclear Magnetic Resonance Enables Study of Heterogeneous Samples in Metal Containers. / Burueva, Dudari B.; Eills, James; Blanchard, John W. et al.

In: Angewandte Chemie - International Edition, Vol. 59, No. 39, 21.09.2020, p. 17026-17032.

Research output: Contribution to journal › Article › peer-review

Harvard

Burueva, DB, Eills, J, Blanchard, JW, Garcon, A, Picazo-Frutos, R, Kovtunov, KV, Koptyug, IV & Budker, D 2020, 'Chemical Reaction Monitoring using Zero-Field Nuclear Magnetic Resonance Enables Study of Heterogeneous Samples in Metal Containers', Angewandte Chemie - International Edition, vol. 59, no. 39, pp. 17026-17032. https://doi.org/10.1002/anie.202006266

APA

Burueva, D. B., Eills, J., Blanchard, J. W., Garcon, A., Picazo-Frutos, R., Kovtunov, K. V., Koptyug, I. V., & Budker, D. (2020). Chemical Reaction Monitoring using Zero-Field Nuclear Magnetic Resonance Enables Study of Heterogeneous Samples in Metal Containers. Angewandte Chemie - International Edition, 59(39), 17026-17032. https://doi.org/10.1002/anie.202006266

Vancouver

Burueva DB, Eills J, Blanchard JW, Garcon A, Picazo-Frutos R, Kovtunov KV et al. Chemical Reaction Monitoring using Zero-Field Nuclear Magnetic Resonance Enables Study of Heterogeneous Samples in Metal Containers. Angewandte Chemie - International Edition. 2020 Sept 21;59(39):17026-17032. Epub 2020 Jun 8. doi: 10.1002/anie.202006266

Author

Burueva, Dudari B. ; Eills, James ; Blanchard, John W. et al. / Chemical Reaction Monitoring using Zero-Field Nuclear Magnetic Resonance Enables Study of Heterogeneous Samples in Metal Containers. In: Angewandte Chemie - International Edition. 2020 ; Vol. 59, No. 39. pp. 17026-17032.

BibTeX

@article{75d445e7f6a943c7886055bc45c94f84,

title = "Chemical Reaction Monitoring using Zero-Field Nuclear Magnetic Resonance Enables Study of Heterogeneous Samples in Metal Containers",

abstract = "We demonstrate that heterogeneous/biphasic chemical reactions can be monitored with high spectroscopic resolution using zero-field nuclear magnetic resonance spectroscopy. This is possible because magnetic susceptibility broadening is negligible at ultralow magnetic fields. We show the two-step hydrogenation of dimethyl acetylenedicarboxylate with para-enriched hydrogen gas in conventional glass NMR tubes, as well as in a titanium tube. The low frequency zero-field NMR signals ensure that there is no significant signal attenuation arising from shielding by the electrically conductive sample container. This method paves the way for in situ monitoring of reactions in complex heterogeneous multiphase systems and in reactors made of conductive materials while maintaining resolution and chemical specificity.",

keywords = "catalysis, hyperpolarization, NMR spectroscopy, reaction monitoring, zero-field, PARA-HYDROGEN, SPIN DYNAMICS, NMR-SPECTROSCOPY, PARAHYDROGEN, FLOW, KINETICS, CHEMISTRY, COUPLINGS, CATIONIC RHODIUM COMPLEXES, POLARIZATION TRANSFER",

author = "Burueva, {Dudari B.} and James Eills and Blanchard, {John W.} and Antoine Garcon and Rom{\'a}n Picazo-Frutos and Kovtunov, {Kirill V.} and Koptyug, {Igor V.} and Dmitry Budker",

year = "2020",

month = sep,

day = "21",

doi = "10.1002/anie.202006266",

language = "English",

volume = "59",

pages = "17026--17032",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "39",

}

RIS

TY - JOUR

T1 - Chemical Reaction Monitoring using Zero-Field Nuclear Magnetic Resonance Enables Study of Heterogeneous Samples in Metal Containers

AU - Burueva, Dudari B.

AU - Eills, James

AU - Blanchard, John W.

AU - Garcon, Antoine

AU - Picazo-Frutos, Román

AU - Kovtunov, Kirill V.

AU - Koptyug, Igor V.

AU - Budker, Dmitry

PY - 2020/9/21

Y1 - 2020/9/21

N2 - We demonstrate that heterogeneous/biphasic chemical reactions can be monitored with high spectroscopic resolution using zero-field nuclear magnetic resonance spectroscopy. This is possible because magnetic susceptibility broadening is negligible at ultralow magnetic fields. We show the two-step hydrogenation of dimethyl acetylenedicarboxylate with para-enriched hydrogen gas in conventional glass NMR tubes, as well as in a titanium tube. The low frequency zero-field NMR signals ensure that there is no significant signal attenuation arising from shielding by the electrically conductive sample container. This method paves the way for in situ monitoring of reactions in complex heterogeneous multiphase systems and in reactors made of conductive materials while maintaining resolution and chemical specificity.

AB - We demonstrate that heterogeneous/biphasic chemical reactions can be monitored with high spectroscopic resolution using zero-field nuclear magnetic resonance spectroscopy. This is possible because magnetic susceptibility broadening is negligible at ultralow magnetic fields. We show the two-step hydrogenation of dimethyl acetylenedicarboxylate with para-enriched hydrogen gas in conventional glass NMR tubes, as well as in a titanium tube. The low frequency zero-field NMR signals ensure that there is no significant signal attenuation arising from shielding by the electrically conductive sample container. This method paves the way for in situ monitoring of reactions in complex heterogeneous multiphase systems and in reactors made of conductive materials while maintaining resolution and chemical specificity.

KW - catalysis

KW - hyperpolarization

KW - NMR spectroscopy

KW - reaction monitoring

KW - zero-field

KW - PARA-HYDROGEN

KW - SPIN DYNAMICS

KW - NMR-SPECTROSCOPY

KW - PARAHYDROGEN

KW - FLOW

KW - KINETICS

KW - CHEMISTRY

KW - COUPLINGS

KW - CATIONIC RHODIUM COMPLEXES

KW - POLARIZATION TRANSFER

UR - http://www.scopus.com/inward/record.url?scp=85088515698&partnerID=8YFLogxK

U2 - 10.1002/anie.202006266

DO - 10.1002/anie.202006266

M3 - Article

C2 - 32510813

AN - SCOPUS:85088515698

VL - 59

SP - 17026

EP - 17032

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 39

ER -

ID: 24823035