Research output: Contribution to journal › Article › peer-review
Candidate SNP Markers Significantly Altering the Affinity of TATA-Binding Protein for the Promoters of Human Hub Genes for Atherogenesis, Atherosclerosis and Atheroprotection. / Bogomolov, Anton; Filonov, Sergey; Chadaeva, Irina et al.
In: International Journal of Molecular Sciences, Vol. 24, No. 10, 9010, 19.05.2023.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Candidate SNP Markers Significantly Altering the Affinity of TATA-Binding Protein for the Promoters of Human Hub Genes for Atherogenesis, Atherosclerosis and Atheroprotection
AU - Bogomolov, Anton
AU - Filonov, Sergey
AU - Chadaeva, Irina
AU - Rasskazov, Dmitry
AU - Khandaev, Bato
AU - Zolotareva, Karina
AU - Kazachek, Anna
AU - Oshchepkov, Dmitry
AU - Ivanisenko, Vladimir A
AU - Demenkov, Pavel
AU - Podkolodnyy, Nikolay
AU - Kondratyuk, Ekaterina
AU - Ponomarenko, Petr
AU - Podkolodnaya, Olga
AU - Mustafin, Zakhar
AU - Savinkova, Ludmila
AU - Kolchanov, Nikolay
AU - Tverdokhleb, Natalya
AU - Ponomarenko, Mikhail
N1 - Funding: This study was supported by the Russian Federal Science and Technology Program for the Development of Genetic Technologies. We are thankful to the multi-access bioinformatics center for the use of computational resources as supported by Russian government project No. FWNR-2022-0020
PY - 2023/5/19
Y1 - 2023/5/19
N2 - Atherosclerosis is a systemic disease in which focal lesions in arteries promote the build-up of lipoproteins and cholesterol they are transporting. The development of atheroma (atherogenesis) narrows blood vessels, reduces the blood supply and leads to cardiovascular diseases. According to the World Health Organization (WHO), cardiovascular diseases are the leading cause of death, which has been especially boosted since the COVID-19 pandemic. There is a variety of contributors to atherosclerosis, including lifestyle factors and genetic predisposition. Antioxidant diets and recreational exercises act as atheroprotectors and can retard atherogenesis. The search for molecular markers of atherogenesis and atheroprotection for predictive, preventive and personalized medicine appears to be the most promising direction for the study of atherosclerosis. In this work, we have analyzed 1068 human genes associated with atherogenesis, atherosclerosis and atheroprotection. The hub genes regulating these processes have been found to be the most ancient. In silico analysis of all 5112 SNPs in their promoters has revealed 330 candidate SNP markers, which statistically significantly change the affinity of the TATA-binding protein (TBP) for these promoters. These molecular markers have made us confident that natural selection acts against underexpression of the hub genes for atherogenesis, atherosclerosis and atheroprotection. At the same time, upregulation of the one for atheroprotection promotes human health.
AB - Atherosclerosis is a systemic disease in which focal lesions in arteries promote the build-up of lipoproteins and cholesterol they are transporting. The development of atheroma (atherogenesis) narrows blood vessels, reduces the blood supply and leads to cardiovascular diseases. According to the World Health Organization (WHO), cardiovascular diseases are the leading cause of death, which has been especially boosted since the COVID-19 pandemic. There is a variety of contributors to atherosclerosis, including lifestyle factors and genetic predisposition. Antioxidant diets and recreational exercises act as atheroprotectors and can retard atherogenesis. The search for molecular markers of atherogenesis and atheroprotection for predictive, preventive and personalized medicine appears to be the most promising direction for the study of atherosclerosis. In this work, we have analyzed 1068 human genes associated with atherogenesis, atherosclerosis and atheroprotection. The hub genes regulating these processes have been found to be the most ancient. In silico analysis of all 5112 SNPs in their promoters has revealed 330 candidate SNP markers, which statistically significantly change the affinity of the TATA-binding protein (TBP) for these promoters. These molecular markers have made us confident that natural selection acts against underexpression of the hub genes for atherogenesis, atherosclerosis and atheroprotection. At the same time, upregulation of the one for atheroprotection promotes human health.
KW - Humans
KW - TATA-Box Binding Protein/genetics
KW - Polymorphism, Single Nucleotide
KW - Cardiovascular Diseases/genetics
KW - Pandemics
KW - COVID-19/genetics
KW - Atherosclerosis/genetics
KW - TATA Box
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85160377000&origin=inward&txGid=f0fd259111c01206fd2a1bb8dc0d4a49
U2 - 10.3390/ijms24109010
DO - 10.3390/ijms24109010
M3 - Article
C2 - 37240358
VL - 24
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 10
M1 - 9010
ER -
ID: 50518962