Research output: Contribution to journal › Article › peer-review
Biosensors Based on SOI Nanowire Transistors for Biomedicine and Virusology. / Naumova, O. V.; Generalov, V. M.; Zaitseva, E. G. et al.
In: Russian Microelectronics, Vol. 50, No. 3, 05.2021, p. 137-145.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Biosensors Based on SOI Nanowire Transistors for Biomedicine and Virusology
AU - Naumova, O. V.
AU - Generalov, V. M.
AU - Zaitseva, E. G.
AU - Latyshev, A. V.
AU - Aseev, A. L.
AU - Pyankov, S. A.
AU - Kolosova, I. V.
AU - Ananko, G. G.
AU - Agafonov, A. P.
AU - Gavrilova, E. V.
AU - Maksyutov, R. A.
AU - Safatov, A. S.
N1 - Funding Information: The authors thank Boris Ivanovich Fomin, the leading researcher at Rzhanov Institute of Semiconductor Physics, Siberian Branch, Russian Academy of Sciences (ISP SB RAS), who has died untimely, and the main developer of the SOI sensor technology, without whose contribution none of the listed works of the authors, including this one, would have appeared. The authors thank Doctor of Physics D.V. Shcheglova for discussing and assisting in organizing the study. Funding Information: This study was supported by grant no. 18-29-02091 of the Russian Foundation for Basic Research. Publisher Copyright: © 2021, Pleiades Publishing, Ltd.
PY - 2021/5
Y1 - 2021/5
N2 - This article contains the results of research on the topical problem of highly sensitive express registration of biological objects using field-effect transistors with the surface open for analyte access, which are made based on silicon-on-insulator (SOI) films. The possibilities of dielectrophoretic effects for controlling the concentration of the analyte in the area of sensory elements are considered on the example of the indication of viruses of nuclear polyhedrosis and vaccinia. It is shown that the use of the dielectrophoresis (DEPh) effect makes it possible to solve (1) the key tasks for creating sensor systems: increasing the detecting ability, as well as exrtacting and verifying the signal from the target particles; and (2) the fundamental task: determining the charge state of the analyte in solutions without modifying the sensors’ surface. The problems and prospects of the mass application of nanowire (NW) biosensors, including those with the dielectrophoretic effect, in biotechnology, virology, etc., are discussed.
AB - This article contains the results of research on the topical problem of highly sensitive express registration of biological objects using field-effect transistors with the surface open for analyte access, which are made based on silicon-on-insulator (SOI) films. The possibilities of dielectrophoretic effects for controlling the concentration of the analyte in the area of sensory elements are considered on the example of the indication of viruses of nuclear polyhedrosis and vaccinia. It is shown that the use of the dielectrophoresis (DEPh) effect makes it possible to solve (1) the key tasks for creating sensor systems: increasing the detecting ability, as well as exrtacting and verifying the signal from the target particles; and (2) the fundamental task: determining the charge state of the analyte in solutions without modifying the sensors’ surface. The problems and prospects of the mass application of nanowire (NW) biosensors, including those with the dielectrophoretic effect, in biotechnology, virology, etc., are discussed.
UR - http://www.scopus.com/inward/record.url?scp=85106331986&partnerID=8YFLogxK
UR - https://www.elibrary.ru/item.asp?id=46086458
U2 - 10.1134/S1063739721030069
DO - 10.1134/S1063739721030069
M3 - Article
AN - SCOPUS:85106331986
VL - 50
SP - 137
EP - 145
JO - Russian Microelectronics
JF - Russian Microelectronics
SN - 1063-7397
IS - 3
ER -
ID: 34108730