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Architecture of Promoters of House-Keeping Genes in Polytene Chromosome Interbands of Drosophila melanogaster. / Zykova, T. Yu; Levitsky, V. G.; Zhimulev, I. F.

In: Doklady Biochemistry and Biophysics, Vol. 485, No. 1, 01.03.2019, p. 95-100.

Research output: Contribution to journal › Article › peer-review

Harvard

Zykova, TY, Levitsky, VG & Zhimulev, IF 2019, 'Architecture of Promoters of House-Keeping Genes in Polytene Chromosome Interbands of Drosophila melanogaster', Doklady Biochemistry and Biophysics, vol. 485, no. 1, pp. 95-100. https://doi.org/10.1134/S1607672919020029

APA

Zykova, T. Y., Levitsky, V. G., & Zhimulev, I. F. (2019). Architecture of Promoters of House-Keeping Genes in Polytene Chromosome Interbands of Drosophila melanogaster. Doklady Biochemistry and Biophysics, 485(1), 95-100. https://doi.org/10.1134/S1607672919020029

Vancouver

Zykova TY, Levitsky VG, Zhimulev IF. Architecture of Promoters of House-Keeping Genes in Polytene Chromosome Interbands of Drosophila melanogaster. Doklady Biochemistry and Biophysics. 2019 Mar 1;485(1):95-100. doi: 10.1134/S1607672919020029

Author

Zykova, T. Yu ; Levitsky, V. G. ; Zhimulev, I. F. / Architecture of Promoters of House-Keeping Genes in Polytene Chromosome Interbands of Drosophila melanogaster. In: Doklady Biochemistry and Biophysics. 2019 ; Vol. 485, No. 1. pp. 95-100.

BibTeX

@article{230b08cb603240328a02dc353dc1fc3a,
title = "Architecture of Promoters of House-Keeping Genes in Polytene Chromosome Interbands of Drosophila melanogaster",
abstract = "Abstract: This is the first study to investigate the molecular-genetic organization of polytene chromosome interbands located on both molecular and cytological maps of Drosophila genome. The majority of the studied interbands contained one gene with a single transcription initiation site; the remaining interbands contained one gene with several alternative promoters, two or more unidirectional genes, and “head-to-head” arranged genes. In addition, intricately arranged interbands containing three or more genes in both unidirectional and bidirectional orientation were found. Insulator proteins, ORC, P-insertions, DNase I hypersensitive sites, and other open chromatin structures were situated in the promoter region of the genes located in the interbands. This area is critical for the formation of the interband, an open chromatin region in which gene transcription and replication are combined.",
keywords = "ORGANIZATION, Promoter Regions, Genetic, Animals, Polytene Chromosomes/genetics, Drosophila melanogaster, Genes, Essential, DNA Transposable Elements",
author = "Zykova, {T. Yu} and Levitsky, {V. G.} and Zhimulev, {I. F.}",
note = "Publisher Copyright: {\textcopyright} 2019, Pleiades Publishing, Ltd.",
year = "2019",
month = mar,
day = "1",
doi = "10.1134/S1607672919020029",
language = "English",
volume = "485",
pages = "95--100",
journal = "Doklady Biochemistry and Biophysics",
issn = "1607-6729",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "1",

}

RIS

TY - JOUR

T1 - Architecture of Promoters of House-Keeping Genes in Polytene Chromosome Interbands of Drosophila melanogaster

AU - Zykova, T. Yu

AU - Levitsky, V. G.

AU - Zhimulev, I. F.

N1 - Publisher Copyright: © 2019, Pleiades Publishing, Ltd.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Abstract: This is the first study to investigate the molecular-genetic organization of polytene chromosome interbands located on both molecular and cytological maps of Drosophila genome. The majority of the studied interbands contained one gene with a single transcription initiation site; the remaining interbands contained one gene with several alternative promoters, two or more unidirectional genes, and “head-to-head” arranged genes. In addition, intricately arranged interbands containing three or more genes in both unidirectional and bidirectional orientation were found. Insulator proteins, ORC, P-insertions, DNase I hypersensitive sites, and other open chromatin structures were situated in the promoter region of the genes located in the interbands. This area is critical for the formation of the interband, an open chromatin region in which gene transcription and replication are combined.

AB - Abstract: This is the first study to investigate the molecular-genetic organization of polytene chromosome interbands located on both molecular and cytological maps of Drosophila genome. The majority of the studied interbands contained one gene with a single transcription initiation site; the remaining interbands contained one gene with several alternative promoters, two or more unidirectional genes, and “head-to-head” arranged genes. In addition, intricately arranged interbands containing three or more genes in both unidirectional and bidirectional orientation were found. Insulator proteins, ORC, P-insertions, DNase I hypersensitive sites, and other open chromatin structures were situated in the promoter region of the genes located in the interbands. This area is critical for the formation of the interband, an open chromatin region in which gene transcription and replication are combined.

KW - ORGANIZATION

KW - Promoter Regions, Genetic

KW - Animals

KW - Polytene Chromosomes/genetics

KW - Drosophila melanogaster

KW - Genes, Essential

KW - DNA Transposable Elements

UR - http://www.scopus.com/inward/record.url?scp=85065027724&partnerID=8YFLogxK

U2 - 10.1134/S1607672919020029

DO - 10.1134/S1607672919020029

M3 - Article

C2 - 31201623

AN - SCOPUS:85065027724

VL - 485

SP - 95

EP - 100

JO - Doklady Biochemistry and Biophysics

JF - Doklady Biochemistry and Biophysics

SN - 1607-6729

IS - 1

ER -

ID: 20589115