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Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells. / Frolova, T. S.; Lipeeva, A. V.; Baev, D. S. et al.

In: Molekuliarnaia biologiia, Vol. 51, No. 5, 01.09.2017, p. 809-816.

Research output: Contribution to journal › Article › peer-review

Harvard

Frolova, TS, Lipeeva, AV, Baev, DS, Tsepilov, YA & Sinitsyna, OI 2017, 'Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells', Molekuliarnaia biologiia, vol. 51, no. 5, pp. 809-816. https://doi.org/10.7868/S002689841705007X

APA

Frolova, T. S., Lipeeva, A. V., Baev, D. S., Tsepilov, Y. A., & Sinitsyna, O. I. (2017). Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells. Molekuliarnaia biologiia, 51(5), 809-816. https://doi.org/10.7868/S002689841705007X

Vancouver

Frolova TS, Lipeeva AV, Baev DS, Tsepilov YA, Sinitsyna OI. Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells. Molekuliarnaia biologiia. 2017 Sept 1;51(5):809-816. doi: 10.7868/S002689841705007X

Author

Frolova, T. S. ; Lipeeva, A. V. ; Baev, D. S. et al. / Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells. In: Molekuliarnaia biologiia. 2017 ; Vol. 51, No. 5. pp. 809-816.

BibTeX

@article{71eaca8b3825434f863fdb74b685e202,
title = "Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells",
abstract = "Pentacyclic triterpene acids are of great interest as compounds that exhibit selective cytotoxicity against malignant tumor cells. If earlier studies were carried out mainly in cancer cells of epithelial origin, in the present work the cytotoxic effect of ursolic and pomolic acids on the primary and permanent glioma cell lines was analyzed. Both compounds are toxic to oncotransformed cells and induce apoptosis in U-87 MG line. Using molecular docking, it has been shown that Akt1 and MDM2 may be potential targets of the studied triterpene acids. It has been suggested that ursolic and pomolic acids induce apoptosis in glioma cells through inhibition of the PI3K/Akt signaling pathway, and they can be considered as potentially promising agents for the treatment of glioblastoma.",
keywords = "apoptosis, glioma, pomolic acid, selective cytotoxicity, ursolic acid, Apoptosis/drug effects, Cell Line, Tumor, Cytotoxins/chemistry, Glioma/drug therapy, Humans, Molecular Docking Simulation, Oleanolic Acid/analogs & derivatives, Proto-Oncogene Proteins c-akt/chemistry, Proto-Oncogene Proteins c-mdm2/chemistry, Signal Transduction/drug effects, Triterpenes/chemistry",
author = "Frolova, {T. S.} and Lipeeva, {A. V.} and Baev, {D. S.} and Tsepilov, {Y. A.} and Sinitsyna, {O. I.}",
year = "2017",
month = sep,
day = "1",
doi = "10.7868/S002689841705007X",
language = "English",
volume = "51",
pages = "809--816",
journal = "Molekulyarnaya Biologiya",
issn = "0026-8984",
publisher = "Russian Academy of Sciences",
number = "5",

}

RIS

TY - JOUR

T1 - Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells

AU - Frolova, T. S.

AU - Lipeeva, A. V.

AU - Baev, D. S.

AU - Tsepilov, Y. A.

AU - Sinitsyna, O. I.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Pentacyclic triterpene acids are of great interest as compounds that exhibit selective cytotoxicity against malignant tumor cells. If earlier studies were carried out mainly in cancer cells of epithelial origin, in the present work the cytotoxic effect of ursolic and pomolic acids on the primary and permanent glioma cell lines was analyzed. Both compounds are toxic to oncotransformed cells and induce apoptosis in U-87 MG line. Using molecular docking, it has been shown that Akt1 and MDM2 may be potential targets of the studied triterpene acids. It has been suggested that ursolic and pomolic acids induce apoptosis in glioma cells through inhibition of the PI3K/Akt signaling pathway, and they can be considered as potentially promising agents for the treatment of glioblastoma.

AB - Pentacyclic triterpene acids are of great interest as compounds that exhibit selective cytotoxicity against malignant tumor cells. If earlier studies were carried out mainly in cancer cells of epithelial origin, in the present work the cytotoxic effect of ursolic and pomolic acids on the primary and permanent glioma cell lines was analyzed. Both compounds are toxic to oncotransformed cells and induce apoptosis in U-87 MG line. Using molecular docking, it has been shown that Akt1 and MDM2 may be potential targets of the studied triterpene acids. It has been suggested that ursolic and pomolic acids induce apoptosis in glioma cells through inhibition of the PI3K/Akt signaling pathway, and they can be considered as potentially promising agents for the treatment of glioblastoma.

KW - apoptosis

KW - glioma

KW - pomolic acid

KW - selective cytotoxicity

KW - ursolic acid

KW - Apoptosis/drug effects

KW - Cell Line, Tumor

KW - Cytotoxins/chemistry

KW - Glioma/drug therapy

KW - Humans

KW - Molecular Docking Simulation

KW - Oleanolic Acid/analogs & derivatives

KW - Proto-Oncogene Proteins c-akt/chemistry

KW - Proto-Oncogene Proteins c-mdm2/chemistry

KW - Signal Transduction/drug effects

KW - Triterpenes/chemistry

UR - http://www.scopus.com/inward/record.url?scp=85049071614&partnerID=8YFLogxK

U2 - 10.7868/S002689841705007X

DO - 10.7868/S002689841705007X

M3 - Article

C2 - 29116067

AN - SCOPUS:85049071614

VL - 51

SP - 809

EP - 816

JO - Molekulyarnaya Biologiya

JF - Molekulyarnaya Biologiya

SN - 0026-8984

IS - 5

ER -

ID: 14279901