Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells

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Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells. / Frolova, T. S.; Lipeeva, A. V.; Baev, D. S. et al.

In: Molecular Biology, Vol. 51, No. 5, 01.09.2017, p. 705-711.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{62a7fa9bc59641c0979e86558fdbe6a6,

title = "Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells",

abstract = "Pentacyclic triterpene acids are of great interest as compounds that exhibit selective cytotoxicity against malignant tumor cells. If earlier studies were carried out mainly in cancer cells of epithelial origin, in the present work the cytotoxic effect of ursolic and pomolic acids on the primary and permanent glioma cell lines was analyzed. Both compounds are toxic to oncotransformed cells and induce apoptosis in U-87 MG line. Using molecular docking, it has been shown that Akt1 and MDM2 may be potential targets of the studied triterpene acids. It has been suggested that ursolic and pomolic acids induce apoptosis in glioma cells through inhibition of the PI3K/Akt signaling pathway, and they can be considered as potentially promising agents for the treatment of glioblastoma.",

keywords = "apoptosis, glioma, pomolic acid, selective cytotoxicity, ursolic acid",

author = "Frolova, {T. S.} and Lipeeva, {A. V.} and Baev, {D. S.} and Tsepilov, {Y. A.} and Sinitsyna, {O. I.}",

note = "Publisher Copyright: {\textcopyright} 2017, Pleiades Publishing, Inc.",

year = "2017",

month = sep,

day = "1",

doi = "10.1134/S0026893317050090",

language = "English",

volume = "51",

pages = "705--711",

journal = "Molecular Biology",

issn = "0026-8933",

publisher = "Maik Nauka-Interperiodica Publishing",

number = "5",

}

RIS

TY - JOUR

T1 - Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells

AU - Frolova, T. S.

AU - Lipeeva, A. V.

AU - Baev, D. S.

AU - Tsepilov, Y. A.

AU - Sinitsyna, O. I.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Pentacyclic triterpene acids are of great interest as compounds that exhibit selective cytotoxicity against malignant tumor cells. If earlier studies were carried out mainly in cancer cells of epithelial origin, in the present work the cytotoxic effect of ursolic and pomolic acids on the primary and permanent glioma cell lines was analyzed. Both compounds are toxic to oncotransformed cells and induce apoptosis in U-87 MG line. Using molecular docking, it has been shown that Akt1 and MDM2 may be potential targets of the studied triterpene acids. It has been suggested that ursolic and pomolic acids induce apoptosis in glioma cells through inhibition of the PI3K/Akt signaling pathway, and they can be considered as potentially promising agents for the treatment of glioblastoma.

AB - Pentacyclic triterpene acids are of great interest as compounds that exhibit selective cytotoxicity against malignant tumor cells. If earlier studies were carried out mainly in cancer cells of epithelial origin, in the present work the cytotoxic effect of ursolic and pomolic acids on the primary and permanent glioma cell lines was analyzed. Both compounds are toxic to oncotransformed cells and induce apoptosis in U-87 MG line. Using molecular docking, it has been shown that Akt1 and MDM2 may be potential targets of the studied triterpene acids. It has been suggested that ursolic and pomolic acids induce apoptosis in glioma cells through inhibition of the PI3K/Akt signaling pathway, and they can be considered as potentially promising agents for the treatment of glioblastoma.

KW - apoptosis

KW - glioma

KW - pomolic acid

KW - selective cytotoxicity

KW - ursolic acid

UR - http://www.scopus.com/inward/record.url?scp=85031414336&partnerID=8YFLogxK

U2 - 10.1134/S0026893317050090

DO - 10.1134/S0026893317050090

M3 - Article

AN - SCOPUS:85031414336

VL - 51

SP - 705

EP - 711

JO - Molecular Biology

JF - Molecular Biology

SN - 0026-8933

IS - 5

ER -

ID: 9892429