TY - CONF

T1 - Activity of DNA glycosylases on non-canonical DNA substrates

AU - Дятлова, Евгения Алексеевна

AU - Жарков, Дмитрий Олегович

N1 - Conference code: 12

PY - 2020

Y1 - 2020

N2 - Until recently, DNA repair was almost exclusively considered in the B-DNA context, since non-canonical DNA was not believed t be a significant target for damage in the bulk genome. A paradigm shift that followed the discoveries of functionally important roles of non-canonical DNA and the cases of apparent connection of regulation with DNA damage put DNA repair in non-canonical structures into the focus of active studies. In this work we investigated base excision repair in non-canonical DNA structures involving hairpins, quadruplexes and DNA/RNA heteroduplexes

AB - Until recently, DNA repair was almost exclusively considered in the B-DNA context, since non-canonical DNA was not believed t be a significant target for damage in the bulk genome. A paradigm shift that followed the discoveries of functionally important roles of non-canonical DNA and the cases of apparent connection of regulation with DNA damage put DNA repair in non-canonical structures into the focus of active studies. In this work we investigated base excision repair in non-canonical DNA structures involving hairpins, quadruplexes and DNA/RNA heteroduplexes

UR - https://www.mendeley.com/catalogue/b67922fd-aff8-30b2-a8ce-94bf3d2c7de9/

U2 - 10.18699/BGRS/SB-2020-346

DO - 10.18699/BGRS/SB-2020-346

M3 - Abstract

SP - 568

T2 - Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia)

Y2 - 6 July 2020 through 10 July 2020

ER -