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A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases. / Zaitseva, Olga O.; Lauc, Gordan; Шарапов, Содбо Жамбалович et al.

2020. 134-135 Abstract from Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia), Новосибирск, Russian Federation.

Research output: Contribution to conference › Abstract › peer-review

Harvard

Zaitseva, OO, Lauc, G, Шарапов, СЖ, Цепилов, ЯА & Klarić, L 2020, 'A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases', Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia), Новосибирск, Russian Federation, 06.07.2020 - 10.07.2020 pp. 134-135. https://doi.org/10.18699/BGRS/SB-2020-085

APA

Zaitseva, O. O., Lauc, G., Шарапов, С. Ж., Цепилов, Я. А., & Klarić, L. (2020). A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases. 134-135. Abstract from Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia), Новосибирск, Russian Federation. https://doi.org/10.18699/BGRS/SB-2020-085

Vancouver

Zaitseva OO, Lauc G, Шарапов СЖ, Цепилов ЯА, Klarić L. A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases. 2020. Abstract from Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia), Новосибирск, Russian Federation. doi: 10.18699/BGRS/SB-2020-085

Author

Zaitseva, Olga O. ; Lauc, Gordan ; Шарапов, Содбо Жамбалович et al. / A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases. Abstract from Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia), Новосибирск, Russian Federation.2 p.

BibTeX

@conference{14ea0449e9ec463692c44345e2e2f69e,
title = "A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases",
abstract = "N-glycosylation of IgG affects ligand binding, antigen recognition and modulates immune response. IgG N- glycome is altered in many pathological states, including cancers, autoimmune and inflammatory diseases. However, the causal relationships between diseases and IgG N-glycosylation traits remain enigmatic. In the current study we implement a Mendelian Randomization approach to study causal effect of IgG N-glycan traits on 12 diseases and vice versa. We have found limited genetic evidence that increased risk of systemic lupus erythematosus might lead to increased bisection of IgG N- glycans.",
author = "Zaitseva, {Olga O.} and Gordan Lauc and Шарапов, {Содбо Жамбалович} and Цепилов, {Яков Александрович} and Lucija Klari{\'c}",
note = "The work of OOZ and GL was supported by the Croatian National Centre of Research Excellence in Personalized Healthcare grant (#KK.01.1.1.01.0010). The work of SZSh was supported by the Russian Science Foundation grant number 19-15-00115. The work of LK was supported by the RCUK Innovation Fellowship from the National Productivity Investment Fund (MR/R026408/1).The work of YAT was supported by the Russian Ministry of Science and Education under the 5-100 Excellence Programme by the Federal Agency of Scientific Organizations via the Institute of Cytology and Genetics (project 0324-2019-0040-C- 01/АААА-А17-117092070032-4).; Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia) ; Conference date: 06-07-2020 Through 10-07-2020",
year = "2020",
doi = "10.18699/BGRS/SB-2020-085",
language = "English",
pages = "134--135",
url = "https://bgrssb.icgbio.ru/2020/",

}

RIS

TY - CONF

T1 - A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases

AU - Zaitseva, Olga O.

AU - Lauc, Gordan

AU - Шарапов, Содбо Жамбалович

AU - Цепилов, Яков Александрович

AU - Klarić, Lucija

N1 - Conference code: 12

PY - 2020

Y1 - 2020

N2 - N-glycosylation of IgG affects ligand binding, antigen recognition and modulates immune response. IgG N- glycome is altered in many pathological states, including cancers, autoimmune and inflammatory diseases. However, the causal relationships between diseases and IgG N-glycosylation traits remain enigmatic. In the current study we implement a Mendelian Randomization approach to study causal effect of IgG N-glycan traits on 12 diseases and vice versa. We have found limited genetic evidence that increased risk of systemic lupus erythematosus might lead to increased bisection of IgG N- glycans.

AB - N-glycosylation of IgG affects ligand binding, antigen recognition and modulates immune response. IgG N- glycome is altered in many pathological states, including cancers, autoimmune and inflammatory diseases. However, the causal relationships between diseases and IgG N-glycosylation traits remain enigmatic. In the current study we implement a Mendelian Randomization approach to study causal effect of IgG N-glycan traits on 12 diseases and vice versa. We have found limited genetic evidence that increased risk of systemic lupus erythematosus might lead to increased bisection of IgG N- glycans.

UR - https://www.elibrary.ru/item.asp?id=44042203

UR - https://www.mendeley.com/catalogue/24272a09-fcaf-37aa-b515-c59185eb7c7a/

U2 - 10.18699/BGRS/SB-2020-085

DO - 10.18699/BGRS/SB-2020-085

M3 - Abstract

SP - 134

EP - 135

T2 - Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia)

Y2 - 6 July 2020 through 10 July 2020

ER -

ID: 27653373