A single coned Poly-Biz moderator designed for animal irradiation in boron neutron capture therapy

Standard

A single coned Poly-Biz moderator designed for animal irradiation in boron neutron capture therapy. / Sycheva, Tatiana ; Berendeev, Evgenii; Verkhovod, Gleb et al.

In: Applied Radiation and Isotopes, Vol. 198, 110818, 08.2023.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{cba648da91ce41dca591fed2c4dd78a7,

title = "A single coned Poly-Biz moderator designed for animal irradiation in boron neutron capture therapy",

abstract = "BNCT is considered to be a promising method for the treatment of malignant tumors, which ensures the selective destruction of malignant tumor cells by accumulating non-radioactive atomic boron-10 nuclei in them and subsequent irradiation with neutrons. As a result of the absorption of a neutron by boron, a nuclear reaction occurs with the release of energy in a cell containing boron, which leads to its death. To date, two drugs for targeted delivery of boron, boronophenylalanine and sodium borocaptate, have been developed, which ensures selective accumulation of boron in a number of tumors, and a number of charged particle accelerators with neutron-generating targets and with neutron beam shaping assemblies have been developed providing the quality of the neutron beam required for therapy. The paper presents a critical analysis of the methods used to form a therapeutic neutron beam and proposes a new concept of a neutron beam shaping assembly, supported by the results of numerical simulation validated by in-phantom measurements.",

author = "Tatiana Sycheva and Evgenii Berendeev and Gleb Verkhovod and Sergey Taskaev",

year = "2023",

month = aug,

doi = "10.1016/j.apradiso.2023.110818",

language = "English",

volume = "198",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier Ltd",

}

RIS

TY - JOUR

T1 - A single coned Poly-Biz moderator designed for animal irradiation in boron neutron capture therapy

AU - Sycheva, Tatiana

AU - Berendeev, Evgenii

AU - Verkhovod, Gleb

AU - Taskaev, Sergey

PY - 2023/8

Y1 - 2023/8

N2 - BNCT is considered to be a promising method for the treatment of malignant tumors, which ensures the selective destruction of malignant tumor cells by accumulating non-radioactive atomic boron-10 nuclei in them and subsequent irradiation with neutrons. As a result of the absorption of a neutron by boron, a nuclear reaction occurs with the release of energy in a cell containing boron, which leads to its death. To date, two drugs for targeted delivery of boron, boronophenylalanine and sodium borocaptate, have been developed, which ensures selective accumulation of boron in a number of tumors, and a number of charged particle accelerators with neutron-generating targets and with neutron beam shaping assemblies have been developed providing the quality of the neutron beam required for therapy. The paper presents a critical analysis of the methods used to form a therapeutic neutron beam and proposes a new concept of a neutron beam shaping assembly, supported by the results of numerical simulation validated by in-phantom measurements.

AB - BNCT is considered to be a promising method for the treatment of malignant tumors, which ensures the selective destruction of malignant tumor cells by accumulating non-radioactive atomic boron-10 nuclei in them and subsequent irradiation with neutrons. As a result of the absorption of a neutron by boron, a nuclear reaction occurs with the release of energy in a cell containing boron, which leads to its death. To date, two drugs for targeted delivery of boron, boronophenylalanine and sodium borocaptate, have been developed, which ensures selective accumulation of boron in a number of tumors, and a number of charged particle accelerators with neutron-generating targets and with neutron beam shaping assemblies have been developed providing the quality of the neutron beam required for therapy. The paper presents a critical analysis of the methods used to form a therapeutic neutron beam and proposes a new concept of a neutron beam shaping assembly, supported by the results of numerical simulation validated by in-phantom measurements.

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85159587061&origin=inward&txGid=21846cff930ba37c6bf04a5d275edbee

U2 - 10.1016/j.apradiso.2023.110818

DO - 10.1016/j.apradiso.2023.110818

M3 - Article

C2 - 37196433

VL - 198

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

SN - 0969-8043

M1 - 110818

ER -

ID: 49828908