Standard

A new polymorph of metacetamol. / McGregor, Lindsay; Rychkov, Denis A.; Coster, Paul L. et al.

In: CrystEngComm, Vol. 17, No. 32, 28.08.2015, p. 6183-6192.

Research output: Contribution to journal › Article › peer-review

Harvard

McGregor, L, Rychkov, DA, Coster, PL, Day, S, Drebushchak, VA, Achkasov, AF, Nichol, GS, Pulham, CR & Boldyreva, EV 2015, 'A new polymorph of metacetamol', CrystEngComm, vol. 17, no. 32, pp. 6183-6192. https://doi.org/10.1039/c5ce00910c

APA

McGregor, L., Rychkov, D. A., Coster, P. L., Day, S., Drebushchak, V. A., Achkasov, A. F., Nichol, G. S., Pulham, C. R., & Boldyreva, E. V. (2015). A new polymorph of metacetamol. CrystEngComm, 17(32), 6183-6192. https://doi.org/10.1039/c5ce00910c

Vancouver

McGregor L, Rychkov DA, Coster PL, Day S, Drebushchak VA, Achkasov AF et al. A new polymorph of metacetamol. CrystEngComm. 2015 Aug 28;17(32):6183-6192. doi: 10.1039/c5ce00910c

Author

McGregor, Lindsay ; Rychkov, Denis A. ; Coster, Paul L. et al. / A new polymorph of metacetamol. In: CrystEngComm. 2015 ; Vol. 17, No. 32. pp. 6183-6192.

BibTeX

@article{17abd6a1e9d648ac8f7c9977e75eef29,
title = "A new polymorph of metacetamol",
abstract = "Metacetamol is a structural isomer of the widely used drug paracetamol and is being considered as a promising alternative to the latter because of its lower toxicity. Due to the importance of the well-known polymorphism of paracetamol, an investigation of the polymorphism of metacetamol was successfully undertaken. A new polymorph of metacetamol has been discovered and extensively characterised using a variety of analytical techniques (IR- and Raman spectroscopy, UV-visible optical spectroscopy, X-ray powder and single-crystal diffraction, TGA and DSC). A procedure for the reliable and reproducible preparation of the new polymorph is described. Its properties and crystal structure are compared with those of the previously known polymorph, as well as with those of paracetamol.",
author = "Lindsay McGregor and Rychkov, {Denis A.} and Coster, {Paul L.} and Sarah Day and Drebushchak, {Valeri A.} and Achkasov, {Andrei F.} and Nichol, {Gary S.} and Pulham, {Colin R.} and Boldyreva, {Elena V.}",
year = "2015",
month = aug,
day = "28",
doi = "10.1039/c5ce00910c",
language = "English",
volume = "17",
pages = "6183--6192",
journal = "CrystEngComm",
issn = "1466-8033",
publisher = "Royal Society of Chemistry",
number = "32",

}

RIS

TY - JOUR

T1 - A new polymorph of metacetamol

AU - McGregor, Lindsay

AU - Rychkov, Denis A.

AU - Coster, Paul L.

AU - Day, Sarah

AU - Drebushchak, Valeri A.

AU - Achkasov, Andrei F.

AU - Nichol, Gary S.

AU - Pulham, Colin R.

AU - Boldyreva, Elena V.

PY - 2015/8/28

Y1 - 2015/8/28

N2 - Metacetamol is a structural isomer of the widely used drug paracetamol and is being considered as a promising alternative to the latter because of its lower toxicity. Due to the importance of the well-known polymorphism of paracetamol, an investigation of the polymorphism of metacetamol was successfully undertaken. A new polymorph of metacetamol has been discovered and extensively characterised using a variety of analytical techniques (IR- and Raman spectroscopy, UV-visible optical spectroscopy, X-ray powder and single-crystal diffraction, TGA and DSC). A procedure for the reliable and reproducible preparation of the new polymorph is described. Its properties and crystal structure are compared with those of the previously known polymorph, as well as with those of paracetamol.

AB - Metacetamol is a structural isomer of the widely used drug paracetamol and is being considered as a promising alternative to the latter because of its lower toxicity. Due to the importance of the well-known polymorphism of paracetamol, an investigation of the polymorphism of metacetamol was successfully undertaken. A new polymorph of metacetamol has been discovered and extensively characterised using a variety of analytical techniques (IR- and Raman spectroscopy, UV-visible optical spectroscopy, X-ray powder and single-crystal diffraction, TGA and DSC). A procedure for the reliable and reproducible preparation of the new polymorph is described. Its properties and crystal structure are compared with those of the previously known polymorph, as well as with those of paracetamol.

UR - http://www.scopus.com/inward/record.url?scp=84938490728&partnerID=8YFLogxK

U2 - 10.1039/c5ce00910c

DO - 10.1039/c5ce00910c

M3 - Article

AN - SCOPUS:84938490728

VL - 17

SP - 6183

EP - 6192

JO - CrystEngComm

JF - CrystEngComm

SN - 1466-8033

IS - 32

ER -

ID: 22580410