Research output: Contribution to journal › Article › peer-review
A fourth Denisovan individual. / Slon, Viviane; Viola, Bence; Renaud, Gabriel et al.
In: Science advances, Vol. 3, No. 7, 1700186, 05.07.2017.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - A fourth Denisovan individual
AU - Slon, Viviane
AU - Viola, Bence
AU - Renaud, Gabriel
AU - Gansauge, Marie Theres
AU - Benazzi, Stefano
AU - Sawyer, Susanna
AU - Hublin, Jean Jacques
AU - Shunkov, Michael V.
AU - Derevianko, Anatoly P.
AU - Kelso, Janet
AU - Prüfer, Kay
AU - Meyer, Matthias
AU - Pääbo, Svante
N1 - This work was supported by the Max Planck Society, the Max Planck Foundation(grant 31-12LMP Pääbo to S.P.), the European Research Council (grant agreement no. 694707to S.P.), the Social Sciences and Humanities Research Council (IDG 430-2016-00590 to B.V.),and the Russian Science Foundation (project no. 14-50-00036 to M.V.S. and A.P.D.).
PY - 2017/7/5
Y1 - 2017/7/5
N2 - The presence of Neandertals in Europe and Western Eurasia before the arrival of anatomically modern humans is well supported by archaeological and paleontological data. In contrast, fossil evidence for Denisovans, a sister group of Neandertals recently identified on the basis of DNA sequences, is limited to three specimens, all of which originate from Denisova Cave in the Altai Mountains (Siberia, Russia). We report the retrieval of DNA from a deciduous lower second molar (Denisova 2), discovered in a deep stratigraphic layer in Denisova Cave, and show that this tooth comes from a female Denisovan individual. On the basis of the number of "missing substitutions" in the mitochondrial DNA determined from the specimen, we find that Denisova 2 is substantially older than two of the other Denisovans, reinforcing the view that Denisovans were likely to have been present in the vicinity of Denisova Cave over an extended time period. We show that the level of nuclear DNA sequence diversity found among Denisovans is within the lower range of that of present-day human populations.
AB - The presence of Neandertals in Europe and Western Eurasia before the arrival of anatomically modern humans is well supported by archaeological and paleontological data. In contrast, fossil evidence for Denisovans, a sister group of Neandertals recently identified on the basis of DNA sequences, is limited to three specimens, all of which originate from Denisova Cave in the Altai Mountains (Siberia, Russia). We report the retrieval of DNA from a deciduous lower second molar (Denisova 2), discovered in a deep stratigraphic layer in Denisova Cave, and show that this tooth comes from a female Denisovan individual. On the basis of the number of "missing substitutions" in the mitochondrial DNA determined from the specimen, we find that Denisova 2 is substantially older than two of the other Denisovans, reinforcing the view that Denisovans were likely to have been present in the vicinity of Denisova Cave over an extended time period. We show that the level of nuclear DNA sequence diversity found among Denisovans is within the lower range of that of present-day human populations.
KW - ADMIXTURE
KW - ANCIENT DNA
KW - CAVE
KW - CONTAMINATION
KW - DNA-SEQUENCES
KW - HOMININ
KW - INTROGRESSION
KW - MITOCHONDRIAL GENOME SEQUENCE
KW - NEANDERTHAL
KW - PHYLOGENIES
UR - http://www.scopus.com/inward/record.url?scp=85029352668&partnerID=8YFLogxK
U2 - 10.1126/sciadv.1700186
DO - 10.1126/sciadv.1700186
M3 - Article
C2 - 28695206
AN - SCOPUS:85029352668
VL - 3
JO - Science advances
JF - Science advances
SN - 2375-2548
IS - 7
M1 - 1700186
ER -
ID: 12179339