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  1. 2025

  2. Isoxazole-linked 7-hydroxycoumarin–2,6-dimethylheptane conjugates as inhibitors of TDP1 enzyme

    Tsypyshev, D. O., Zakharenko, A. L., Podurina, M. V., Khomenko, T. M., Kondrashov, E. V., Lavrik, O. I., Volcho, K. P. & Salakhutdinov, N. F., 2025, In: Mendeleev Communications. 35, 4, p. 444-446 3 p.

    Research output: Contribution to journal › Article › peer-review

  3. 2024

  4. Sulfide, Sulfoxide, and Sulfone Derivatives of Usnic Acid as Inhibitors of Human TDP1 and TDP2 Enzymes

    Filimonov, A. S., Mikhailova, M. A., Dyrkheeva, N. S., Chernyshova, I. A., Kornienko, T. E., Naumenko, K. A., Anarbaev, R. O., Nefedov, A. A., Achara, C., Curtis, A. D. M., Luzina, O. A., Volcho, K. P., Salakhutdinov, N. F., Lavrik, O. I. & Reynisson, J., 17 Dec 2024, In: Chemistry (Switzerland). 6, 6, p. 1658-1679 22 p.

    Research output: Contribution to journal › Article › peer-review

  5. Proteins Associated with Neurodegenerative Diseases: Link to DNA Repair

    Khodyreva, S. N., Dyrkheeva, N. S. & Lavrik, O. I., 11 Dec 2024, In: Biomedicines. 12, 12, 2808.

    Research output: Contribution to journal › Article › peer-review

  6. Novel Peptide–Drug Conjugates with Dual Anticancer Activity

    O’Flaherty, S., Luzina, O. A., Dyrkheeva, N. S., Krier, Y., Leprince, J., Zakharenko, A. L., Pokrovsky, M. A., Pokrovsky, A. G., Lavrik, O. I., Salakhutdinov, N. F., Varbanov, M., Devocelle, M. & Volcho, K. P., 19 Nov 2024, In: International Journal of Molecular Sciences. 25, 22, 12411.

    Research output: Contribution to journal › Article › peer-review

  7. Apurinic/apyrimidinic endonuclease 1 has major impact in prevention of suicidal covalent DNA–protein crosslink with apurinic/apyrimidinic site in cellular extracts

    Lebedeva, N. A., Dyrkheeva, N. S., Rechkunova, N. I. & Lavrik, O. I., Nov 2024, In: IUBMB Life. 76, 11, p. 987-996 10 p.

    Research output: Contribution to journal › Article › peer-review

  8. Сравнительный анализ первичной структуры и получение рекомбинантной поли(ADP-рибоза)полимеразы 1 долгоживущего Heterocephalus glaber

    Naumenko, K. N., Nurislamov, A. R., Nazarov, K. D., Fishman, V. S., Popov, A. A., Petruseva, I. O., Evdokimov, A. N. & Lavrik, O. I., Nov 2024, In: Vavilovskii Zhurnal Genetiki i Selektsii. 28, 7, p. 688-695 8 p., 2.

    Research output: Contribution to journal › Article › peer-review

  9. Does the XPA–FEN1 Interaction Concern to Nucleotide Excision Repair or Beyond?

    Krasikova, Y. S., Maltseva, E. A., Khodyreva, S. N., Evdokimov, A. N., Rechkunova, N. I. & Lavrik, O. I., Jul 2024, In: Biomolecules. 14, 7, 814.

    Research output: Contribution to journal › Article › peer-review

  10. Use of qPCR to Evaluate Efficiency of the Bulky DNA Damage Removal in Extracts of Mammalian Cells with Different Maximum Lifespan

    Popov, A. A., Shamanin, V. A., Petruseva, I. O., Evdokimov, A. N. & Lavrik, O. I., Jul 2024, In: Biochemistry (Moscow). 89, 7, p. 1183-1191 9 p., 2.

    Research output: Contribution to journal › Article › peer-review

  11. Activity of DNA Repair Systems in the Cells of Long-Lived Rodents and Bats

    Popov, A. A., Petruseva, I. O. & Lavrik, O. I., Jun 2024, In: Biochemistry (Moscow). 89, 6, p. 1014-1023 10 p.

    Research output: Contribution to journal › Article › peer-review

  12. Studying Structure and Functions of Nucleosomes with Atomic Force Microscopy

    Ukraintsev, A. A., Kutuzov, M. M. & Lavrik, O. I., Apr 2024, In: Biochemistry (Moscow). 89, 4, p. 674-687 14 p.

    Research output: Contribution to journal › Review article › peer-review

  13. A Knockout of Poly(ADP-Ribose) Polymerase 1 in a Human Cell Line: An Influence on Base Excision Repair Reactions in Cellular Extracts

    Khodyreva, S. N., Ilina, E. S., Dyrkheeva, N. S., Kochetkova, A. S., Yamskikh, A. A., Maltseva, E. A., Malakhova, A. A., Medvedev, S. P., Zakian, S. M. & Lavrik, O. I., Feb 2024, In: Cells. 13, 4, 302.

    Research output: Contribution to journal › Article › peer-review

  14. 2023

  15. Synthesis of Norabietyl and Nordehydroabietyl Imidazolidine-2,4,5-Triones and Their Activity against Tyrosyl-DNA Phosphodiesterase 1

    Kovaleva, K. S., Yarovaya, O. I., Chernyshova, I. A., Zakharenko, A. L., Cheresiz, S. V., Azimirad, A., Pokrovsky, A. G., Lavrik, O. I. & Salakhutdinov, N. F., Dec 2023, In: MolBank. 2023, 4, М1743.

    Research output: Contribution to journal › Article › peer-review

  16. Pharmacokinetic study of Tdp1 inhibitor resulted in a significant increase in antitumor effect in the treatment of Lewis lung carcinoma in mice by its combination with topotecan

    Okhina, A. A., Kornienko, T. E., Rogachev, A. D., Luzina, O. A., Popova, N. A., Nikolin, V. P., Zakharenko, A. L., Dyrkheeva, N. S., Pokrovsky, A. G., Salakhutdinov, N. F. & Lavrik, O. I., 30 Nov 2023, In: Journal of Pharmaceutical and Biomedical Analysis. 236, 9 p., 115731.

    Research output: Contribution to journal › Article › peer-review

  17. Cas9 is mostly orthogonal to human systems of DNA break sensing and repair

    Maltseva, E. A., Vasil'eva, I. A., Moor, N. A., Kim, D. V., Dyrkheeva, N. S., Kutuzov, M. M., Vokhtantsev, I. P., Kulishova, L. M., Zharkov, D. O. & Lavrik, O. I., 29 Nov 2023, In: PLoS ONE. 18, 11, 26 p., e0294683.

    Research output: Contribution to journal › Article › peer-review

  18. Methods for Assessment of Nucleotide Excision Repair Efficiency

    Popov, A. A., Petruseva, I. O., Naumenko, N. V. & Lavrik, O. I., Nov 2023, In: Biochemistry (Moscow). 88, 11, p. 1844-1856 13 p.

    Research output: Contribution to journal › Review article › peer-review

  19. FUS RRM regulates poly(ADP-ribose) levels after transcriptional arrest and PARP-1 activation on DNA damage

    Mamontova, E. M., Clément, M-J., Sukhanova, M. V., Joshi, V., Bouhss, A., Rengifo-Gonzalez, J. C., Desforges, B., Hamon, L., Lavrik, O. I. & Pastré, D., 31 Oct 2023, In: Cell Reports. 42, 10, 25 p., 113199.

    Research output: Contribution to journal › Article › peer-review

  20. Effect of Usnic Acid-Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitor Used as Monotherapy or in Combination with Olaparib on Transplanted Tumors In Vivo

    Kornienko, T. E., Zakharenko, A. L., Ilina, E. S., Chepanova, A. A., Zakharova, O. D., Dyrkheeva, N. S., Popova, N. A., Nikolin, V. P., Filimonov, A. S., Luzina, O. A., Salakhutdinov, N. F. & Lavrik, O. I., Apr 2023, In: Molecular Biology. 57, 2, p. 214-224 11 p.

    Research output: Contribution to journal › Article › peer-review

  21. Influence of the Poly(ADP-Ribose) Polymerase 1 Level on the Status of Base Excision Repair in Human Cells

    Ilina, E. S., Kochetkova, A. S., Belousova, E. A., Kutuzov, M. M., Lavrik, O. I. & Khodyreva, S. N., Apr 2023, In: Molecular Biology. 57, 2, p. 272-283 12 p.

    Research output: Contribution to journal › Article › peer-review

  22. Poly(ADP-Ribose) Polymerases 1 and 2: Classical Functions and Interaction with New Histone Poly(ADP-Ribosyl)ation Factor HPF1

    Kurgina, T. A. & Lavrik, O. I., Apr 2023, In: Molecular Biology. 57, 2, p. 245-257 13 p.

    Research output: Contribution to journal › Article › peer-review

  23. Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor

    Dyrkheeva, N. S., Malakhova, A. A., Zakharenko, A. L., Okorokova, L. S., Shtokalo, D. N., Pavlova, S. V., Medvedev, S. P., Zakian, S. M., Nushtaeva, A. A., Tupikin, A. E., Kabilov, M. R., Khodyreva, S. N., Luzina, O. A., Salakhutdinov, N. F. & Lavrik, O. I., 7 Mar 2023, In: International Journal of Molecular Sciences. 24, 6, 5148.

    Research output: Contribution to journal › Article › peer-review

  24. Влияние производного усниновой кислоты (ингибитора тирозил-ДНК-фосфодиэстеразы 1) на трансплантированные опухоли in vivo в качестве монотерапии и в сочетании с олапарибом

    Kornienko, T. E., Zakharenko, A. L., Ilina, E. S., Chepanova, A. A., Zakharova, O. D., Dyrkheeva, N. S., Popova, N. A., Nikolin, V. P., Filimonov, A. S., Luzina, O. A., Salakhutdinov, N. F. & Lavrik, O. I., 1 Mar 2023, In: Molekuliarnaia biologiia. 57, 2, p. 220-231 12 p., 8.

    Research output: Contribution to journal › Article › peer-review

  25. Влияние уровня поли(ADP-рибоза)полимеразы 1 на статус системы эксцизионной репарации оснований в клетках человека

    Ilina, E. S., Kochetkova, A. S., Belousova, E. A., Kutuzov, M. M., Lavrik, O. I. & Khodyreva, S. N., 1 Mar 2023, In: Molekuliarnaia biologiia. 57, 2, p. 285-298 14 p., 13.

    Research output: Contribution to journal › Article › peer-review

  26. Поли(АDP-рибоза)полимеразы 1 и 2: классические функции и взаимодействие с HPF1 ‒ новым фактором поли(ADP-рибозил)ирования гистонов

    Kurgina, T. A. & Lavrik, O. I., 1 Mar 2023, In: Molekuliarnaia biologiia. 57, 2, p. 254-268 15 p., 11.

    Research output: Contribution to journal › Article › peer-review

  27. Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties

    Ivankin, D. I., Kornienko, T. E., Mikhailova, M. A., Dyrkheeva, N. S., Zakharenko, A. L., Achara, C., Reynisson, J., Golyshev, V. M., Luzina, O. A., Volcho, K. P., Salakhutdinov, N. F. & Lavrik, O. I., 14 Feb 2023, In: International Journal of Molecular Sciences. 24, 4, 3834.

    Research output: Contribution to journal › Article › peer-review

  28. The Lipophilic Purine Nucleoside-Tdp1 Inhibitor-Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo

    Chernyshova, I. A., Zakharenko, A. L., Kurochkin, N. N., Dyrkheeva, N. S., Kornienko, T. E., Popova, N. A., Nikolin, V. P., Ilina, E. S., Zharkov, T. D., Kupryushkin, M. S., Oslovsky, V. E., Drenichev, M. S. & Lavrik, O. I., Jan 2023, In: Molecules (Basel, Switzerland). 28, 1, 323.

    Research output: Contribution to journal › Article › peer-review

  29. 2022

  30. The HPF1-dependent histone PARylation catalyzed by PARP2 is specifically stimulated by an incised AP site-containing BER DNA intermediate

    Kurgina, T. A., Moor, N. A., Kutuzov, M. M. & Lavrik, O. I., Dec 2022, In: DNA Repair. 120, 103423.

    Research output: Contribution to journal › Article › peer-review

  31. The XPA Protein—Life under Precise Control

    Krasikova, Y. S., Lavrik, O. I. & Rechkunova, N. I., Dec 2022, In: Cells. 11, 23, 3723.

    Research output: Contribution to journal › Review article › peer-review

  32. Poly(ADP-ribose) in Condensates: The PARtnership of Phase Separation and Site-Specific Interactions

    Alemasova, E. E. & Lavrik, O. I., Nov 2022, In: International Journal of Molecular Sciences. 23, 22, 14075.

    Research output: Contribution to journal › Review article › peer-review

  33. A sePARate phase? Poly(ADP-ribose) versus RNA in the organization of biomolecular condensates

    Alemasova, E. E. & Lavrik, O. I., 28 Oct 2022, In: Nucleic Acids Research. 50, 19, p. 10817-10838 22 p.

    Research output: Contribution to journal › Review article › peer-review

  34. Inhibitory Effects of 7-Methylguanine and Its Metabolite 8-Hydroxy-7-Methylguanine on Human Poly(ADP-Ribose) Polymerase 1

    Kurgina, T. A., Shram, S. I., Kutuzov, M. M., Abramova, T. V., Shcherbakova, T. A., Maltseva, E. A., Poroikov, V. V., Lavrik, O. I., Švedas, V. K. & Nilov, D. K., Aug 2022, In: Biochemistry (Moscow). 87, 8, p. 823-831 9 p.

    Research output: Contribution to journal › Article › peer-review

  35. Structural features of DNA polymerases β and λ in complex with benzo[a]pyrene-adducted DNA cause a difference in lesion tolerance

    Rechkunova, N. I., Zhdanova, P. V., Lebedeva, N. A., Maltseva, E. A., Koval, V. V. & Lavrik, O. I., Aug 2022, In: DNA Repair. 116, 103353.

    Research output: Contribution to journal › Article › peer-review

  36. The C-Terminal Domain of Y-Box Binding Protein 1 Exhibits Structure-Specific Binding to Poly(ADP-Ribose), Which Regulates PARP1 Activity

    Naumenko, K. N., Sukhanova, M. V., Hamon, L., Kurgina, T. A., Anarbaev, R. O., Mangerich, A., Pastré, D. & Lavrik, O. I., 21 Jun 2022, In: Frontiers in Cell and Developmental Biology. 10, 831741.

    Research output: Contribution to journal › Article › peer-review

  37. Study of Interaction of the PARP Family DNA-Dependent Proteins with Nucleosomes Containing DNA Intermediates of the Initial Stages of BER Process

    Ukraintsev, A. A., Belousova, E. A., Kutuzov, M. M. & Lavrik, O. I., Apr 2022, In: Biochemistry (Moscow). 87, 4, p. 331-345 15 p.

    Research output: Contribution to journal › Article › peer-review

  38. Inhibition of the DNA repair enzyme TDP1 by the resin acid derivatives as a new way to increase the efficiency of glioblastoma chemotherapy

    Kovaleva, K., Oleshko, O., Yarovaya, O., Cheresiz, S., Zakharenko, A., Ponomarev, K., Lavrik, O., Pokrovsky, A. & Salakhutdinov, N., 4 Feb 2022, Actual Problems of Organic Chemistry and Biotechnology, OCBT 2020: Proceedings of the International Scientific Conference. Bakulev, V., Kovaleva, E., Glukhareva, T., Beryozkina, T., Schafran, Y., Lyubyakina, P. & Koptyaeva, O. (eds.). American Institute of Physics Inc., 020036. (AIP Conference Proceedings; vol. 2390).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Research › peer-review

  39. Role of YB-1 in Regulation of Poly(ADP-Ribosylation) Catalyzed by Poly(ADP-Ribose) Polymerases

    Alemasova, E. E., Naumenko, K. N., Sukhanova, M. V. & Lavrik, O. I., Jan 2022, In: Biochemistry (Moscow). 87, Suppl 1, p. S32-S47

    Research output: Contribution to journal › Review article › peer-review

  40. 2021

  41. Dual function of HPF1 in the modulation of PARP1 and PARP2 activities

    Kurgina, T. A., Moor, N. A., Kutuzov, M. M., Naumenko, K. N., Ukraintsev, A. A. & Lavrik, O. I., Dec 2021, In: Communications Biology. 4, 1, 1259.

    Research output: Contribution to journal › Article › peer-review

  42. New hybrid compounds combining fragments of usnic acid and thioether are inhibitors of human enzymes TDP1, TDP2 and PARP1

    Dyrkheeva, N. S., Filimonov, A. S., Luzina, O. A., Orlova, K. A., Chernyshova, I. A., Kornienko, T. E., Malakhova, A. A., Medvedev, S. P., Zakharenko, A. L., Ilina, E. S., Anarbaev, R. O., Naumenko, K. N., Klabenkova, K. V., Burakova, E. A., Stetsenko, D. A., Zakian, S. M., Salakhutdinov, N. F. & Lavrik, O. I., 1 Nov 2021, In: International Journal of Molecular Sciences. 22, 21, 11336.

    Research output: Contribution to journal › Article › peer-review

  43. Dehydroabietylamine-based thiazolidin-4-ones and 2-thioxoimidazolidin-4-ones as novel tyrosyl-DNA phosphodiesterase 1 inhibitors

    Kovaleva, K., Mamontova, E., Yarovaya, O., Zakharova, O., Zakharenko, A., Lavrik, O. & Salakhutdinov, N., Nov 2021, In: Molecular Diversity. 25, 4, p. 2389-2397 9 p.

    Research output: Contribution to journal › Article › peer-review

  44. The influence of an enamine usnic acid derivative (a tyrosyl-DNA phosphodiesterase 1 inhibitor) on the therapeutic effect of topotecan against transplanted tumors in vivo

    Nikolin, V. P., Popova, N. A., Kaledin, V. I., Luzina, O. A., Zakharenko, A. L., Salakhutdinov, N. F. & Lavrik, O. I., Oct 2021, In: Clinical and Experimental Metastasis. 38, 5, p. 431-440 10 p.

    Research output: Contribution to journal › Article › peer-review

  45. A Method for Assessing the Efficiency of the Nucleotide Excision Repair System Ex Vivo

    Popov, A. A., Orishchenko, K. E., Naumenko, K. N., Evdokimov, A. N., Petruseva, I. O. & Lavrik, O. I., Sept 2021, In: Acta Naturae. 13, 3, p. 122-125 4 p., 13.

    Research output: Contribution to journal › Article › peer-review

  46. New hybrid compounds combining fragments of usnic acid and monoterpenoids for effective tyrosyl-dna phosphodiesterase 1 inhibition

    Dyrkheeva, N. S., Filimonov, A. S., Luzina, O. A., Zakharenko, A. L., Ilina, E. S., Malakhova, A. A., Medvedev, S. P., Reynisson, J., Volcho, K. P., Zakian, S. M., Salakhutdinov, N. F. & Lavrik, O. I., 1 Jul 2021, In: Biomolecules. 11, 7, 973.

    Research output: Contribution to journal › Article › peer-review

  47. Impact of various poly(ADP-ribose)polymerase 1 level on DNA base excision repair status in human cells

    Kochetkova, A. S., Ilina, E. S., Khodyreva, S. N. & Lavrik, O. I., Jul 2021, In: FEBS Open Bio. 11, p. 190-190 1 p.

    Research output: Contribution to journal › Meeting Abstract › peer-review

  48. PARP1, PARP2 and PARP3 interaction with nucleosomes containing DNA-lesions

    Kurgina, T. A., Kutuzov, M. M., Belousova, E. A., Ukraitsev, A. A., Anarbaev, R. O. & Lavrik, O. I., Jul 2021, In: FEBS Open Bio. 11, p. 244-245 2 p.

    Research output: Contribution to journal › Meeting Abstract › peer-review

  49. Nucleotide excision repair: From molecular defects to neurological abnormalities

    Krasikova, Y., Rechkunova, N. & Lavrik, O., 2 Jun 2021, In: International Journal of Molecular Sciences. 22, 12, 6220.

    Research output: Contribution to journal › Review article › peer-review

  50. PARP1 Regulates the Biogenesis and Activity of Telomerase Complex Through Modification of H/ACA-Proteins

    Savelyev, N. V., Shepelev, N. M., Lavrik, O. I., Rubtsova, M. P. & Dontsova, O. A., 19 May 2021, In: Frontiers in Cell and Developmental Biology. 9, 621134.

    Research output: Contribution to journal › Article › peer-review

  51. Design, synthesis, and molecular docking study of new tyrosyl-dna phosphodiesterase 1 (Tdp1) inhibitors combining resin acids and adamantane moieties

    Kovaleva, K., Yarovaya, O., Ponomarev, K., Cheresiz, S., Azimirad, A., Chernyshova, I., Zakharenko, A., Konev, V., Khlebnikova, T., Mozhaytsev, E., Suslov, E., Nilov, D., Švedas, V., Pokrovsky, A., Lavrik, O. & Salakhutdinov, N., 1 May 2021, In: Pharmaceuticals. 14, 5, 422.

    Research output: Contribution to journal › Article › peer-review

  52. Functional roles of parp2 in assembling protein–protein complexes involved in base excision dna repair

    Vasil’eva, I., Moor, N., Anarbaev, R., Kutuzov, M. & Lavrik, O., 1 May 2021, In: International Journal of Molecular Sciences. 22, 9, 4679.

    Research output: Contribution to journal › Article › peer-review

  53. Triazinylamidophosphate Oligonucleotides: Synthesis and Study of Their Interaction with Cells and DNA-Binding Proteins

    Kupryushkin, M. S., Zharkov, T. D., Ilina, E. S., Markov, O. V., Kochetkova, A. S., Akhmetova, M. M., Lomzov, A. A., Pyshnyi, D. V., Lavrik, O. I. & Khodyreva, S. N., May 2021, In: Russian Journal of Bioorganic Chemistry. 47, 3, p. 719-733 15 p.

    Research output: Contribution to journal › Article › peer-review

  54. Интерактом систем репарации оснований и нуклеотидов

    Rechkunova, N. I., Krasikova, Y. S. & Lavrik, O. I., 20 Apr 2021, In: Molekuliarnaia biologiia. 55, 2, p. 181-193 13 p., 2.

    Research output: Contribution to journal › Review article › peer-review

  55. Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors

    Gladkova, E. D., Chepanova, A. A., Ilina, E. S., Zakharenko, A. L., Reynisson, J., Luzina, O. A., Volcho, K. P., Lavrik, O. I. & Salakhutdinov, N. F., 30 Mar 2021, In: Molecules (Basel, Switzerland). 26, 7, 1945.

    Research output: Contribution to journal › Article › peer-review

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