The Lipophilic Purine Nucleoside-Tdp1 Inhibitor-Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	323
Journal	Molecules (Basel, Switzerland)
Volume	28
Issue number	1
Early online date	31 Dec 2022
DOIs	https://doi.org/10.3390/molecules28010323
Publication status	Published - Jan 2023

Animals, Mice, Humans, Topotecan/pharmacology, Phosphoric Diester Hydrolases/metabolism, Phosphodiesterase Inhibitors/pharmacology, Purine Nucleosides, Structure-Activity Relationship, Topoisomerase I Inhibitors/pharmacology, Esterases/metabolism, DNA Damage, DNA, DNA Topoisomerases, Type I/metabolism, synergy, Tdp1 inhibitor, lipophilic nucleosides, tyrosyl-DNA phosphodiesterase 1, DNA repair, inhibiting activity, topoisomerase I, topotecan

ID: 42504455