TY - JOUR

T1 - Zebrafish models relevant to studying central opioid and endocannabinoid systems

AU - Demin, Konstantin A.

AU - Meshalkina, Darya A.

AU - Kysil, Elana V.

AU - Antonova, Kristina A.

AU - Volgin, Andrey D.

AU - Yakovlev, Oleg A.

AU - Alekseeva, Polina A.

AU - Firuleva, Maria M.

AU - Lakstygal, Anton M.

AU - de Abreu, Murilo S.

AU - Barcellos, Leonardo J.G.

AU - Bao, Wandong

AU - Friend, Ashton J.

AU - Amstislavskaya, Tamara G.

AU - Rosemberg, Denis B.

AU - Musienko, Pavel E.

AU - Song, Cai

AU - Kalueff, Allan V.

N1 - Publisher Copyright: © 2018 Elsevier Inc.

PY - 2018/8/30

Y1 - 2018/8/30

N2 - The endocannabinoid and opioid systems are two interplaying neurotransmitter systems that modulate drug abuse, anxiety, pain, cognition, neurogenesis and immune activity. Although they are involved in such critical functions, our understanding of endocannabinoid and opioid physiology remains limited, necessitating further studies, novel models and new model organisms in this field. Zebrafish (Danio rerio) is rapidly emerging as one of the most effective translational models in neuroscience and biological psychiatry. Due to their high physiological and genetic homology to humans, zebrafish may be effectively used to study the endocannabinoid and opioid systems. Here, we discuss current models used to target the endocannabinoid and opioid systems in zebrafish, and their potential use in future translational research and high-throughput drug screening. Emphasizing the high degree of conservation of the endocannabinoid and opioid systems in zebrafish and mammals, we suggest zebrafish as an excellent model organism to study these systems and to search for the new drugs and therapies targeting their evolutionarily conserved mechanisms.

AB - The endocannabinoid and opioid systems are two interplaying neurotransmitter systems that modulate drug abuse, anxiety, pain, cognition, neurogenesis and immune activity. Although they are involved in such critical functions, our understanding of endocannabinoid and opioid physiology remains limited, necessitating further studies, novel models and new model organisms in this field. Zebrafish (Danio rerio) is rapidly emerging as one of the most effective translational models in neuroscience and biological psychiatry. Due to their high physiological and genetic homology to humans, zebrafish may be effectively used to study the endocannabinoid and opioid systems. Here, we discuss current models used to target the endocannabinoid and opioid systems in zebrafish, and their potential use in future translational research and high-throughput drug screening. Emphasizing the high degree of conservation of the endocannabinoid and opioid systems in zebrafish and mammals, we suggest zebrafish as an excellent model organism to study these systems and to search for the new drugs and therapies targeting their evolutionarily conserved mechanisms.

KW - Endocannabinoid system

KW - High-throughput screening

KW - Opioid system

KW - Zebrafish

KW - HYDROLASE INHIBITOR URB597

KW - CONDITIONED PLACE PREFERENCE

KW - ADULT ZEBRAFISH

KW - ANXIETY-LIKE BEHAVIOR

KW - RAT MODEL

KW - PHYLOGENETIC DISTRIBUTION

KW - CANNABINOID CB1 RECEPTOR

KW - BINDING-SITES

KW - SALVINORIN-A

KW - MOLECULAR-MECHANISMS

KW - Zebrafish/metabolism

KW - Central Nervous System/drug effects

KW - Receptors, Opioid/metabolism

KW - Animals

KW - Models, Animal

KW - Endocannabinoids/metabolism

UR - http://www.scopus.com/inward/record.url?scp=85047070946&partnerID=8YFLogxK

U2 - 10.1016/j.pnpbp.2018.03.024

DO - 10.1016/j.pnpbp.2018.03.024

M3 - Review article

C2 - 29604314

AN - SCOPUS:85047070946

VL - 86

SP - 301

EP - 312

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

SN - 0278-5846

ER -