TY - JOUR

T1 - Water composed of reduced hydrogen bonds activated by localized surface plasmon resonance effectively enhances anti-viral and anti-oxidative activities of melatonin

AU - Renn, Ting Yi

AU - Yang, Chih Ping

AU - Wu, Un In

AU - Chen, Li You

AU - Mai, Fu Der

AU - Tikhonova, Maria A.

AU - Amstislavskaya, Tamara G.

AU - Liao, Wen Chieh

AU - Lin, Che Tong

AU - Liu, Yu Chuan

AU - Chang, Hung Ming

N1 - Funding Information: The authors are grateful to the Core Facility Center, Office of the Research and Development, Taipei Medical University, for its great support in TOF-SIMS analysis. This work was supported by the research grants (MOST 107-2221-E-038-005-MY3 to Dr. Liu, and MOST 107-2633-B-038-001 to Dr. Chang) from The Ministry of Science and Technology, Taipei, Taiwan. Publisher Copyright: © 2021 Elsevier B.V.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Melatonin is a lipophilic antioxidant generally dissolved in organic solvent before delivery. However, the presence of organics may severely depress the functional effects of melatonin. By rendering deionized water (DIW) flow through gold nano-particles under localized surface plasmon resonant illumination, we developed plasmon-activated water (PAW) which successfully increases the solubility of melatonin to 150.325%. Melatonin dissolved in PAW also exhibits stronger anti-viral and anti-oxidative activities than that dissolved in DIW in which the percentage of dengue virus infected human hepatocellular carcinoma cells is remarkably decreased (14.7% vs. 20.6%) whilst the clearance rate of hydroxyl radical is significantly enhanced (11.9% vs. 6.69%), respectively. Moreover, in vivo approaches further show that following chronic sleep deprivation, the level of oxidative stress, hepatic bioenergetics, anti-oxidative enzyme activity, and metabolic function are all significantly improved in rats received melatonin prepared in PAW than that in DIW. As the bio-activity of melatonin depends largely on its solubility, utilizing PAW as a non-organic solvent will not only enhance the anti-viral and anti-oxidative function of melatonin, but also offer great potential for clinical use of melatonin as a therapeutic strategy to depress virus infection and counteract oxidative damage in a more natural, more economic and more efficient way.

AB - Melatonin is a lipophilic antioxidant generally dissolved in organic solvent before delivery. However, the presence of organics may severely depress the functional effects of melatonin. By rendering deionized water (DIW) flow through gold nano-particles under localized surface plasmon resonant illumination, we developed plasmon-activated water (PAW) which successfully increases the solubility of melatonin to 150.325%. Melatonin dissolved in PAW also exhibits stronger anti-viral and anti-oxidative activities than that dissolved in DIW in which the percentage of dengue virus infected human hepatocellular carcinoma cells is remarkably decreased (14.7% vs. 20.6%) whilst the clearance rate of hydroxyl radical is significantly enhanced (11.9% vs. 6.69%), respectively. Moreover, in vivo approaches further show that following chronic sleep deprivation, the level of oxidative stress, hepatic bioenergetics, anti-oxidative enzyme activity, and metabolic function are all significantly improved in rats received melatonin prepared in PAW than that in DIW. As the bio-activity of melatonin depends largely on its solubility, utilizing PAW as a non-organic solvent will not only enhance the anti-viral and anti-oxidative function of melatonin, but also offer great potential for clinical use of melatonin as a therapeutic strategy to depress virus infection and counteract oxidative damage in a more natural, more economic and more efficient way.

KW - Anti-oxidative effects

KW - Anti-viral function

KW - Biomedical application

KW - Hepatic bioenergetics

KW - Melatonin

KW - Plasmon-activated water

UR - http://www.scopus.com/inward/record.url?scp=85113603543&partnerID=8YFLogxK

U2 - 10.1016/j.cej.2021.131626

DO - 10.1016/j.cej.2021.131626

M3 - Article

AN - SCOPUS:85113603543

VL - 427

JO - Chemical Engineering Journal

JF - Chemical Engineering Journal

SN - 1385-8947

M1 - 131626

ER -