Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Virotherapy of the Malignant U87 Human Glioblastoma in the Orthotopic Xenotransplantation Mouse SCID Model. / Shchelkunov, S. N.; Razumov, I. A.; Kolosova, I. V. и др.
в: Doklady Biochemistry and Biophysics, Том 478, № 1, 01.01.2018, стр. 30-33.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
}
TY - JOUR
T1 - Virotherapy of the Malignant U87 Human Glioblastoma in the Orthotopic Xenotransplantation Mouse SCID Model
AU - Shchelkunov, S. N.
AU - Razumov, I. A.
AU - Kolosova, I. V.
AU - Romashchenko, A. V.
AU - Zavjalov, E. L.
N1 - Publisher Copyright: © 2018, Pleiades Publishing, Ltd.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - The possibility of glioblastoma virotherapy at intravenous injection of the LIVP–GFP recombinant virus was studied in experimental model of orthotopic xenotransplantation of human glioblastoma cell line U87 to SCID laboratory mice. The LIVP–GFP recombinant virus deficient for thymidine kinase exhibited a significantly greater oncolytic capacity than the original LIVP virus, and an intravenous injection of LIVP–GFP at the early stages of tumorigenesis in mouse brain in most cases resulted in the lysis of the tumor.
AB - The possibility of glioblastoma virotherapy at intravenous injection of the LIVP–GFP recombinant virus was studied in experimental model of orthotopic xenotransplantation of human glioblastoma cell line U87 to SCID laboratory mice. The LIVP–GFP recombinant virus deficient for thymidine kinase exhibited a significantly greater oncolytic capacity than the original LIVP virus, and an intravenous injection of LIVP–GFP at the early stages of tumorigenesis in mouse brain in most cases resulted in the lysis of the tumor.
UR - http://www.scopus.com/inward/record.url?scp=85043993175&partnerID=8YFLogxK
U2 - 10.1134/S1607672918010088
DO - 10.1134/S1607672918010088
M3 - Article
C2 - 29536305
AN - SCOPUS:85043993175
VL - 478
SP - 30
EP - 33
JO - Doklady Biochemistry and Biophysics
JF - Doklady Biochemistry and Biophysics
SN - 1607-6729
IS - 1
ER -
ID: 12027962