TY - JOUR

T1 - Ultrastructural Changes in Hepatocellular Carcinoma-29 Cells after Treatment with Lithium Carbonate

AU - Taskaeva, Yu S.

AU - Bgatova, N. P.

PY - 2019/5/15

Y1 - 2019/5/15

N2 - We studied the effect of lithium carbonate on hepatocellular carcinoma-29 cells in CBA male mice after injection in a dose of 20 mM along the tumor periphery. Transmission electron microscopy revealed a decrease in the volume density of the granular endoplasmic reticulum in the cell cytoplasm and an increase in the total numerical and volume density of autophagosomes and autolysosomes and zones of destruction of intracellular organelles. The ability of lithium carbonate to activate intracellular degradation processes in tumor cells and to stimulate cell death can be used to develop new combined strategies in the chemotherapy for hepatocellular carcinoma.

AB - We studied the effect of lithium carbonate on hepatocellular carcinoma-29 cells in CBA male mice after injection in a dose of 20 mM along the tumor periphery. Transmission electron microscopy revealed a decrease in the volume density of the granular endoplasmic reticulum in the cell cytoplasm and an increase in the total numerical and volume density of autophagosomes and autolysosomes and zones of destruction of intracellular organelles. The ability of lithium carbonate to activate intracellular degradation processes in tumor cells and to stimulate cell death can be used to develop new combined strategies in the chemotherapy for hepatocellular carcinoma.

KW - autophagy

KW - hepatocellular carcinoma

KW - lithium carbonate

KW - ultrastructural organization

UR - http://www.scopus.com/inward/record.url?scp=85067992916&partnerID=8YFLogxK

U2 - 10.1007/s10517-019-04467-3

DO - 10.1007/s10517-019-04467-3

M3 - Article

C2 - 31177458

AN - SCOPUS:85067992916

VL - 167

SP - 87

EP - 90

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 1

ER -