Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Tuning the Anticancer Activity of Gold(I) Complexes via Redox-Active Ar-Bian Ligands: Experimental and Theoretical Insights. / Shaposhnikov, Nikolay O.; Korotkova, Sofia V.; Komlyagina, Veronika I. и др.
в: Inorganic Chemistry, Том 65, № 40, 2026, стр. 23404-23423.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
}
TY - JOUR
T1 - Tuning the Anticancer Activity of Gold(I) Complexes via Redox-Active Ar-Bian Ligands: Experimental and Theoretical Insights
AU - Shaposhnikov, Nikolay O.
AU - Korotkova, Sofia V.
AU - Komlyagina, Veronika I.
AU - Bakaev, Ivan V.
AU - Ulantikov, Anton A.
AU - Klimina, Katerina V.
AU - Yakovlev, Ivan A.
AU - Kuratieva, Natalia V.
AU - Kompankov, Nikolay B.
AU - Fomenko, Iakov S.
AU - Kharlamova, Viktoria Yu
AU - Shestopalov, Michael A.
AU - Romashev, Nikolai F.
AU - Gushchin, Artem L.
PY - 2026
Y1 - 2026
N2 - A series of cationic gold(I) complexes of the type [Au(PPh3)(Ar-Bian)](CF3SO3) based on 1,2-bis[(2,4,6-trimethylphenyl)imino]acenaphthene (tmp-Bian), 1,2-bis[(4-chlorophenyl)imino]acenaphthene (4–Cl-C6H4–Bian), 1,2-bis[(4-bromophenyl)imino]acenaphthene (4–Br-C6H4–Bian), and 1,2-bis[(4-iodophenyl)imino]acenaphthene (4–I-C6H4–Bian) were prepared. All complexes were fully characterized by spectrochemical methods, and their crystal structures were established by X-ray diffraction analysis. The electrochemical behavior of all complexes was studied by using cyclic voltammetry. The stability of the complexes in solution was investigated using 1H NMR and UV–vis spectroscopies. The anticancer activity of Au(I) complexes was evaluated against a panel of cell lines in comparison with free 1,2-bis(arylimino)aceaphthenes (Ar-Bian) and initial [Au(PPh3)Cl]. All complexes were cytotoxic in a low micromolar range and showed selectivity toward cancer cells in comparison with MRC-5 human lung fibroblasts. The ability of the complexes to bind DNA and BSA was investigated by spectroscopic methods, molecular docking, and molecular dynamics studies. The DNA-damaging activity of gold(I) complexes was evaluated in MCF-7 cells using the comet assay. Reactive oxygen species production in MCF-7 cells was studied using confocal microscopy. The lipophilicity of complexes was determined using the n-octanol/water shake-flask method. Determination of the cell death pathway was performed using an Annexin-5-FITC/PI double staining test followed by fluorescence-activated cell sorting (FACS) analysis.
AB - A series of cationic gold(I) complexes of the type [Au(PPh3)(Ar-Bian)](CF3SO3) based on 1,2-bis[(2,4,6-trimethylphenyl)imino]acenaphthene (tmp-Bian), 1,2-bis[(4-chlorophenyl)imino]acenaphthene (4–Cl-C6H4–Bian), 1,2-bis[(4-bromophenyl)imino]acenaphthene (4–Br-C6H4–Bian), and 1,2-bis[(4-iodophenyl)imino]acenaphthene (4–I-C6H4–Bian) were prepared. All complexes were fully characterized by spectrochemical methods, and their crystal structures were established by X-ray diffraction analysis. The electrochemical behavior of all complexes was studied by using cyclic voltammetry. The stability of the complexes in solution was investigated using 1H NMR and UV–vis spectroscopies. The anticancer activity of Au(I) complexes was evaluated against a panel of cell lines in comparison with free 1,2-bis(arylimino)aceaphthenes (Ar-Bian) and initial [Au(PPh3)Cl]. All complexes were cytotoxic in a low micromolar range and showed selectivity toward cancer cells in comparison with MRC-5 human lung fibroblasts. The ability of the complexes to bind DNA and BSA was investigated by spectroscopic methods, molecular docking, and molecular dynamics studies. The DNA-damaging activity of gold(I) complexes was evaluated in MCF-7 cells using the comet assay. Reactive oxygen species production in MCF-7 cells was studied using confocal microscopy. The lipophilicity of complexes was determined using the n-octanol/water shake-flask method. Determination of the cell death pathway was performed using an Annexin-5-FITC/PI double staining test followed by fluorescence-activated cell sorting (FACS) analysis.
UR - https://www.scopus.com/pages/publications/105053350544
UR - https://www.mendeley.com/catalogue/c7e02798-a5a5-3e83-8f1b-ea749dce92d0/
U2 - 10.1021/acs.inorgchem.6c02443
DO - 10.1021/acs.inorgchem.6c02443
M3 - Article
C2 - 42916887
VL - 65
SP - 23404
EP - 23423
JO - Inorganic Chemistry
JF - Inorganic Chemistry
SN - 0020-1669
IS - 40
ER -
ID: 85047977