Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Tumor-Derived Microvesicles Promote Kidney Regeneration and Cytoprotective Immunomodulation. / Seledtsova, Galina V.; Seledtsov, Victor I.; Dorzhieva, Ayana B. и др.
в: Pharmaceuticals, Том 18, № 10, 1520, 10.10.2025.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Tumor-Derived Microvesicles Promote Kidney Regeneration and Cytoprotective Immunomodulation
AU - Seledtsova, Galina V.
AU - Seledtsov, Victor I.
AU - Dorzhieva, Ayana B.
AU - Blinova, Elena A.
AU - Darinskas, Adas
AU - Prokopyeva, Elena A.
AU - von Delwig, Alexei A.
N1 - Tumor-Derived Microvesicles Promote Kidney Regeneration and Cytoprotective Immunomodulation / G. V. Seledtsova, V. I. Seledtsov, A. B. Dorzhieva, E. A. Blinova, A. Darinskas, E. A. Prokopyeva, A. A. von Delwig // Pharmaceuticals. – 2025. – Vol. 18, No. 10. - С. 1520. DOI 10.3390/ph18101520
PY - 2025/10/10
Y1 - 2025/10/10
N2 - Background: A comparative study was conducted to evaluate the potential of extracellular, tumor-derived microvesicles (MVs)s in promoting kidney regeneration. Methods: MVs were collected from L929 sarcoma, LLC, and B16 melanoma cells, and mesenchymal stem cells (MSCs). The regenerative activity of MVs was evaluated in an experimental murine model of chronic kidney injury (CKI). Results: Both tumor-derived MVs (T-MVs) and MSC-derived MVs (MSC-MVs) significantly improved kidney function and histological structure. Specifically, the height of collecting tubules in the middle third of the renal medulla returned to normal levels following MV treatment. Both T-MVs and MSC-MVs reduced the proportion of pro-inflammatory CD4+CD44+ T cells in renal cell infiltrates and spleens of CKI mice. Furthermore, treatment with these MVs increased the number of natural CD4+CD25+FoxP3+ regulatory T cells in the spleen, indicating their immunomodulatory effects. Conclusions: These findings suggest that T-MVs, similar to MSC-MVs, possess a universal capacity to promote kidney tissue regeneration and exert anti-inflammatory immunomodulatory effects.
AB - Background: A comparative study was conducted to evaluate the potential of extracellular, tumor-derived microvesicles (MVs)s in promoting kidney regeneration. Methods: MVs were collected from L929 sarcoma, LLC, and B16 melanoma cells, and mesenchymal stem cells (MSCs). The regenerative activity of MVs was evaluated in an experimental murine model of chronic kidney injury (CKI). Results: Both tumor-derived MVs (T-MVs) and MSC-derived MVs (MSC-MVs) significantly improved kidney function and histological structure. Specifically, the height of collecting tubules in the middle third of the renal medulla returned to normal levels following MV treatment. Both T-MVs and MSC-MVs reduced the proportion of pro-inflammatory CD4+CD44+ T cells in renal cell infiltrates and spleens of CKI mice. Furthermore, treatment with these MVs increased the number of natural CD4+CD25+FoxP3+ regulatory T cells in the spleen, indicating their immunomodulatory effects. Conclusions: These findings suggest that T-MVs, similar to MSC-MVs, possess a universal capacity to promote kidney tissue regeneration and exert anti-inflammatory immunomodulatory effects.
KW - chronic kidney injury
KW - mesenchymal stem cell
KW - microvesicle
KW - regeneration
KW - tumor
UR - https://www.mendeley.com/catalogue/e137d5ce-d045-35b2-b213-013561d567de/
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=105020195561&origin=inward
U2 - 10.3390/ph18101520
DO - 10.3390/ph18101520
M3 - Article
VL - 18
JO - Pharmaceuticals
JF - Pharmaceuticals
SN - 1424-8247
IS - 10
M1 - 1520
ER -
ID: 71756119