TY - JOUR

T1 - Triple Haplotypes of the TP53 Gene in Patients with Diffuse Small B-Cell Lymphoma

AU - Voropaeva, E. N.

AU - Cherdyntseva, N. V.

AU - Voevoda, M. I.

AU - Pospelova, T. I.

AU - Maximov, V. N.

AU - Orlov, Yu L.

AU - Ageeva, T. A.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - The role of genetic susceptibility to the development of lymphoma is confirmed by the accumulating data on common genetic variants of the genes involved in lymphomogenesis. The varieties of disease variants, as well as the small effect of each of the polymorphisms, require the analysis of these markers in individual histological lymphoma subtypes in haplotype groups. This study was carried out to analyze the frequencies of rs1042522, rs1625895, and rs17878362, their triple haplotypes, and linkage disequilibrium in patients with diffuse small B-cell lymphoma and a control group. The absence of pronounced linkage disequilibrium between the rs17878362, rs1042522, and rs1625895 markers of the TP53 gene in the population control sample was revealed. At the same time, data on significant linkage disequilibrium between rs1625895 and rs1042522, as well as rs1625895 and rs17878362, and on moderate linkage disequilibrium between rs17878362 and rs1042522 in the group of patients with lymphoma were obtained. An association of the haplotype wArgG in the homozygous state with a predisposition to the development of diffuse small B-cell lymphoma was found.

AB - The role of genetic susceptibility to the development of lymphoma is confirmed by the accumulating data on common genetic variants of the genes involved in lymphomogenesis. The varieties of disease variants, as well as the small effect of each of the polymorphisms, require the analysis of these markers in individual histological lymphoma subtypes in haplotype groups. This study was carried out to analyze the frequencies of rs1042522, rs1625895, and rs17878362, their triple haplotypes, and linkage disequilibrium in patients with diffuse small B-cell lymphoma and a control group. The absence of pronounced linkage disequilibrium between the rs17878362, rs1042522, and rs1625895 markers of the TP53 gene in the population control sample was revealed. At the same time, data on significant linkage disequilibrium between rs1625895 and rs1042522, as well as rs1625895 and rs17878362, and on moderate linkage disequilibrium between rs17878362 and rs1042522 in the group of patients with lymphoma were obtained. An association of the haplotype wArgG in the homozygous state with a predisposition to the development of diffuse small B-cell lymphoma was found.

KW - developmental risk

KW - haplotype structure

KW - linkage disequilibrium

KW - non-Hodgkin lymphomas

KW - rs1042522

KW - rs1625895

KW - rs17878362

KW - TP53 gene

KW - CANCER PATIENTS

KW - RISK

KW - P53 POLYMORPHISMS

KW - GENOTYPES

KW - LINKAGE DISEQUILIBRIUM

KW - FREQUENCY

KW - ASSOCIATION

UR - http://www.scopus.com/inward/record.url?scp=85078342936&partnerID=8YFLogxK

U2 - 10.1134/S1022795419120123

DO - 10.1134/S1022795419120123

M3 - Article

AN - SCOPUS:85078342936

VL - 55

SP - 1564

EP - 1568

JO - Russian Journal of Genetics

JF - Russian Journal of Genetics

SN - 1022-7954

IS - 12

ER -