TY - JOUR

T1 - Thraustochytrids: Evolution, Ultrastructure, Biotechnology, and Modeling

AU - Menzorov, Aleksei G.

AU - Iukhtanov, Daniil A.

AU - Naumenko, Ludmila G.

AU - Bobrovskikh, Aleksandr V.

AU - Zubairova, Ulyana S.

AU - Morozova, Ksenia N.

AU - Doroshkov, Alexey V.

N1 - This research was funded by Russian Science Foundation, grant number 24-24-00451.

PY - 2024/12

Y1 - 2024/12

N2 - The thraustochytrids are a group of marine protists known for their significant ecological roles as decomposers and parasites as well as for their potential biotechnological applications, yet their evolutionary and structural diversity remains poorly understood. Our review critically examines the phylogeny of this taxa, utilizing available up-to-date knowledge and their taxonomic classifications. Additionally, advanced imaging techniques, including electron microscopy, are employed to explore the ultrastructural characteristics of these organisms, revealing key features that contribute to their adaptive capabilities in varying marine environments. The integration of this knowledge with available omics data highlights the huge biotechnological potential of thraustochytrids, particularly in producing (Formula presented.) -3 fatty acids and other bioactive compounds. Our review underscores the importance of a systems biology approach in understanding thraustochytrids biology and highlights the urgent need for novel, accurate omics research to unlock their full biotechnological potential. Overall, this review aims to foster a deeper appreciation of thraustochytrids by synthesizing information on their evolution, ultrastructure, and practical applications, thereby providing a foundation for future studies in microbiology and biotechnology.

AB - The thraustochytrids are a group of marine protists known for their significant ecological roles as decomposers and parasites as well as for their potential biotechnological applications, yet their evolutionary and structural diversity remains poorly understood. Our review critically examines the phylogeny of this taxa, utilizing available up-to-date knowledge and their taxonomic classifications. Additionally, advanced imaging techniques, including electron microscopy, are employed to explore the ultrastructural characteristics of these organisms, revealing key features that contribute to their adaptive capabilities in varying marine environments. The integration of this knowledge with available omics data highlights the huge biotechnological potential of thraustochytrids, particularly in producing (Formula presented.) -3 fatty acids and other bioactive compounds. Our review underscores the importance of a systems biology approach in understanding thraustochytrids biology and highlights the urgent need for novel, accurate omics research to unlock their full biotechnological potential. Overall, this review aims to foster a deeper appreciation of thraustochytrids by synthesizing information on their evolution, ultrastructure, and practical applications, thereby providing a foundation for future studies in microbiology and biotechnology.

KW - bioreactor

KW - marine protists

KW - phylogenetics

KW - thraustochytrids

KW - ultrastructure

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85211963641&origin=inward&txGid=40c9b25ce2a1474a0024aeb3fd42f364

UR - https://www.mendeley.com/catalogue/6fe1103b-45f6-313f-b0f1-a1f6291f0a2f/

U2 - 10.3390/ijms252313172

DO - 10.3390/ijms252313172

M3 - Article

VL - 25

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 23

M1 - 13172

ER -