TY - JOUR

T1 - Therapeutic Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Neuroinflammation and Neuroplasticity in Patients with Parkinson’s Disease

T2 - a Placebo-Controlled Study

AU - Aftanas, L. I.

AU - Gevorgyan, M. M.

AU - Zhanaeva, S. Y.

AU - Dzemidovich, S. S.

AU - Kulikova, K. I.

AU - Al’perina, E. L.

AU - Danilenko, K. V.

AU - Idova, G. V.

PY - 2018/6

Y1 - 2018/6

N2 - The parallel placebo-controlled study examined the therapeutic effects of dual-target repetitive transcranial magnetic stimulation (rTMS) of the motor cortex (bilaterally) and the left prefrontal cortex (dorsolaterally) on spontaneous and mitogen-stimulating synthesis of pro- and anti-inflammatory cytokines by the blood cells and the level of brain-derived neurotrophic factor (BDNF) in blood serum of patients with Parkinson’s disease. The significantly steeper positive clinical dynamics (assessed by UPRSD scale) observed in rTMS group in comparison with the placebo group was accompanied by a significant drop in spontaneous production of proinflammatory cytokines IFNγ and IL-17A. rTMS produced no significant effect on serum BDNF. The possible mechanisms of rTMS therapeutic action on the level of cytokines associated with neuroinflammation in patients with Parkinson’s disease are discussed.

AB - The parallel placebo-controlled study examined the therapeutic effects of dual-target repetitive transcranial magnetic stimulation (rTMS) of the motor cortex (bilaterally) and the left prefrontal cortex (dorsolaterally) on spontaneous and mitogen-stimulating synthesis of pro- and anti-inflammatory cytokines by the blood cells and the level of brain-derived neurotrophic factor (BDNF) in blood serum of patients with Parkinson’s disease. The significantly steeper positive clinical dynamics (assessed by UPRSD scale) observed in rTMS group in comparison with the placebo group was accompanied by a significant drop in spontaneous production of proinflammatory cytokines IFNγ and IL-17A. rTMS produced no significant effect on serum BDNF. The possible mechanisms of rTMS therapeutic action on the level of cytokines associated with neuroinflammation in patients with Parkinson’s disease are discussed.

KW - BDNF

KW - Parkinson’s disease

KW - high-frequency repetitive transcranial magnetic stimulation (rTMS)

KW - pro- and anti-inflammatory cytokines

KW - Parkinson's disease

KW - RAT

KW - MOTOR

KW - DOPAMINE

KW - MECHANISMS

UR - http://www.scopus.com/inward/record.url?scp=85048823102&partnerID=8YFLogxK

U2 - 10.1007/s10517-018-4128-4

DO - 10.1007/s10517-018-4128-4

M3 - Article

C2 - 29923005

AN - SCOPUS:85048823102

VL - 165

SP - 195

EP - 199

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 2

ER -