TY - JOUR

T1 - The XPA Protein—Life under Precise Control

AU - Krasikova, Yuliya S.

AU - Lavrik, Olga I.

AU - Rechkunova, Nadejda I.

N1 - Funding Information: This work was funded by the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075-15-2022-263). The APC was funded by the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075-15-2022-263). Publisher Copyright: © 2022 by the authors.

PY - 2022/12

Y1 - 2022/12

N2 - Nucleotide excision repair (NER) is a central DNA repair pathway responsible for removing a wide variety of DNA-distorting lesions from the genome. The highly choreographed cascade of core NER reactions requires more than 30 polypeptides. The xeroderma pigmentosum group A (XPA) protein plays an essential role in the NER process. XPA interacts with almost all NER participants and organizes the correct NER repair complex. In the absence of XPA’s scaffolding function, no repair process occurs. In this review, we briefly summarize our current knowledge about the XPA protein structure and analyze the formation of contact with its protein partners during NER complex assembling. We focus on different ways of regulation of the XPA protein’s activity and expression and pay special attention to the network of post-translational modifications. We also discuss the data that is not in line with the currently accepted hypothesis about the functioning of the XPA protein.

AB - Nucleotide excision repair (NER) is a central DNA repair pathway responsible for removing a wide variety of DNA-distorting lesions from the genome. The highly choreographed cascade of core NER reactions requires more than 30 polypeptides. The xeroderma pigmentosum group A (XPA) protein plays an essential role in the NER process. XPA interacts with almost all NER participants and organizes the correct NER repair complex. In the absence of XPA’s scaffolding function, no repair process occurs. In this review, we briefly summarize our current knowledge about the XPA protein structure and analyze the formation of contact with its protein partners during NER complex assembling. We focus on different ways of regulation of the XPA protein’s activity and expression and pay special attention to the network of post-translational modifications. We also discuss the data that is not in line with the currently accepted hypothesis about the functioning of the XPA protein.

KW - ATR

KW - DNA repair

KW - nucleotide excision repair (NER)

KW - PARP1

KW - PARylation

KW - phosphorylation

KW - post-translational modifications

KW - XPA

KW - Cell Nucleus/metabolism

KW - Humans

KW - Xeroderma Pigmentosum Group A Protein/genetics

KW - DNA Repair

KW - Protein Processing, Post-Translational

UR - http://www.scopus.com/inward/record.url?scp=85143675441&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/733a20f3-969d-3861-942f-4dbfd202ed91/

U2 - 10.3390/cells11233723

DO - 10.3390/cells11233723

M3 - Review article

C2 - 36496984

AN - SCOPUS:85143675441

VL - 11

JO - Cells

JF - Cells

SN - 2073-4409

IS - 23

M1 - 3723

ER -