TY - JOUR

T1 - The role of thrombophilia in the premature detachment of a normally located placenta

AU - Pasman, Natalya M.

AU - Chumanova, Olga V.

N1 - Пасман Н.М., Чуманова О.В. Значение тромбофилии в развитии преждевременной отслойки нормально расположенной плаценты // Акушерство, Гинекология и Репродукция. - 2019. - Т. 13. - № 1. - С. 29-34

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Aim: to study the association between hereditary/acquired thrombophilia and premature detachment of normally located placenta. Materials and methods. The participating women were divided into 2 groups: the main group (n = 38) and the control group (n = 43). The main group included women, whose pregnancy or delivery was complicated by premature detachment of normally located placenta. The control group included women without previous obstetric or thrombotic complications, who gave birth to full-term live babies with an Apgar score of 8-10. The key coagulogram parameters, the presence of hyperhomocysteinemia, antiphospholipide syndrome, and polymorphisms of the hemostasis genes (by realtime polymerase chain reaction) were determined. Results. A statistically significant increase in the concentration of fibrinogen and D-dimer was found in patients of the main group. In addition, allele A of the G1691A polymorphic locus of the factor V gene and allele 4G of the 5G/4G 675 polymorphic locus of the PAI-1 gene are risk factors of placental detachment development. Conclusion. Hereditary and acquired thrombophilia are significant factors in the development of premature detachment of the normally located placenta.

AB - Aim: to study the association between hereditary/acquired thrombophilia and premature detachment of normally located placenta. Materials and methods. The participating women were divided into 2 groups: the main group (n = 38) and the control group (n = 43). The main group included women, whose pregnancy or delivery was complicated by premature detachment of normally located placenta. The control group included women without previous obstetric or thrombotic complications, who gave birth to full-term live babies with an Apgar score of 8-10. The key coagulogram parameters, the presence of hyperhomocysteinemia, antiphospholipide syndrome, and polymorphisms of the hemostasis genes (by realtime polymerase chain reaction) were determined. Results. A statistically significant increase in the concentration of fibrinogen and D-dimer was found in patients of the main group. In addition, allele A of the G1691A polymorphic locus of the factor V gene and allele 4G of the 5G/4G 675 polymorphic locus of the PAI-1 gene are risk factors of placental detachment development. Conclusion. Hereditary and acquired thrombophilia are significant factors in the development of premature detachment of the normally located placenta.

KW - Acquired thrombophilia

KW - Hereditary thrombophilia

KW - Hypercoagulation

KW - Normally located placenta

KW - Premature detachment

UR - http://www.scopus.com/inward/record.url?scp=85085745958&partnerID=8YFLogxK

UR - https://www.elibrary.ru/item.asp?id=37638401

U2 - 10.17749/2313-7347.2019.13.1.029-034

DO - 10.17749/2313-7347.2019.13.1.029-034

M3 - Article

AN - SCOPUS:85085745958

VL - 13

SP - 29

EP - 34

JO - Obstetrics, Gynecology and Reproduction

JF - Obstetrics, Gynecology and Reproduction

SN - 2313-7347

IS - 1

ER -