Результаты исследований: Научные публикации в периодических изданиях › обзорная статья › Рецензирование
The role of the habenula in the transition from reward to misery in substance use and mood disorders. / Batalla, Albert; Homberg, Judith R.; Lipina, Tatiana V. и др.
в: Neuroscience and Biobehavioral Reviews, Том 80, 01.09.2017, стр. 276-285.Результаты исследований: Научные публикации в периодических изданиях › обзорная статья › Рецензирование
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TY - JOUR
T1 - The role of the habenula in the transition from reward to misery in substance use and mood disorders
AU - Batalla, Albert
AU - Homberg, Judith R.
AU - Lipina, Tatiana V.
AU - Sescousse, Guillaume
AU - Luijten, Maartje
AU - Ivanova, Svetlana A.
AU - Schellekens, Arnt F.A.
AU - Loonen, Anton J.M.
N1 - Copyright © 2017 Elsevier Ltd. All rights reserved.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - The habenula (Hb) is an evolutionary well-conserved structure located in the epithalamus. The Hb receives inputs from the septum, basal ganglia, hypothalamus, anterior cingulate and medial prefrontal cortex, and projects to several midbrain centers, most importantly the inhibitory rostromedial tegmental nucleus (RMTg) and the excitatory interpeduncular nucleus (IPN), which regulate the activity of midbrain monoaminergic nuclei. The Hb is postulated to play a key role in reward and aversion processing across species, including humans, and to be implicated in the different stages of transition from recreational drug intake to addiction and co-morbid mood disorders. The Hb is divided into two anatomically and functionally distinct nuclei, the lateral (LHb) and the medial (MHb), which are primarily involved in reward-seeking (LHb) and misery-fleeing (MHb) behavior by controlling the RMTg and IPN, respectively. This review provides a neuroanatomical description of the Hb, discusses preclinical and human findings regarding its role in the development of addiction and co-morbid mood disorders, and addresses future directions in this area.
AB - The habenula (Hb) is an evolutionary well-conserved structure located in the epithalamus. The Hb receives inputs from the septum, basal ganglia, hypothalamus, anterior cingulate and medial prefrontal cortex, and projects to several midbrain centers, most importantly the inhibitory rostromedial tegmental nucleus (RMTg) and the excitatory interpeduncular nucleus (IPN), which regulate the activity of midbrain monoaminergic nuclei. The Hb is postulated to play a key role in reward and aversion processing across species, including humans, and to be implicated in the different stages of transition from recreational drug intake to addiction and co-morbid mood disorders. The Hb is divided into two anatomically and functionally distinct nuclei, the lateral (LHb) and the medial (MHb), which are primarily involved in reward-seeking (LHb) and misery-fleeing (MHb) behavior by controlling the RMTg and IPN, respectively. This review provides a neuroanatomical description of the Hb, discusses preclinical and human findings regarding its role in the development of addiction and co-morbid mood disorders, and addresses future directions in this area.
KW - fmri
KW - Habenula
KW - Mood disorders
KW - Reward
KW - Substance use disorders
KW - Mood Disorders/epidemiology
KW - Animals
KW - Habenula/physiopathology
KW - Comorbidity
KW - Humans
KW - Avoidance Learning/physiology
KW - Substance-Related Disorders/epidemiology
UR - http://www.scopus.com/inward/record.url?scp=85020728325&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2017.03.019
DO - 10.1016/j.neubiorev.2017.03.019
M3 - Review article
C2 - 28576510
AN - SCOPUS:85020728325
VL - 80
SP - 276
EP - 285
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
SN - 0149-7634
ER -
ID: 9981503