TY - JOUR

T1 - The Role of Long Noncoding RNAs in Plants

AU - Pronozin, A. Y.

AU - Afonnikov, D. A.

N1 - This work was carried out with the support of the budget project FWNR-2022-0020. Pronozin, A. Y. The Role of Long Noncoding RNAs in Plants / A. Y. Pronozin, D. A. Afonnikov // Russian Journal of Genetics. – 2025. – Vol. 61, No. 1. – P. 1-18. – DOI 10.1134/S1022795424701345.

PY - 2025/1/20

Y1 - 2025/1/20

N2 - Abstract: Long noncoding RNAs (lncRNAs) are a class of linear or circular RNA molecules longer than 200 nucleotides without open reading frames. Experimental studies have shown the involvement of lncRNAs in the regulation of resistance to cold, salt, and heat stress and in fruit, root, and leaf development. However, experimental methods are labor-intensive and costly approaches and cannot yet be used for genome-wide mass studies of lncRNAs. For this purpose, bioinformatic approaches that aim at large-scale recognition of lncRNA sequences in genomes and transcriptomes have been applied. However, despite the growing number of studies devoted to the structural and functional analysis of lncRNAs, this type of molecule remains poorly understood. This is due to the many factors that need to be considered when identifying lncRNAs. The use of pan-genomes and pan-transcriptomes will improve the efficiency of the study and the total number of predicted lncRNAs compared to using the genome of a single species representative. This review focuses on describing the molecular and biological functions of lncRNAs and experimental and bioinformatic methods of identification, patterns of evolution, and detection and analysis of lncRNAs at the scale of pan-genomes and pan-transcriptomes.

AB - Abstract: Long noncoding RNAs (lncRNAs) are a class of linear or circular RNA molecules longer than 200 nucleotides without open reading frames. Experimental studies have shown the involvement of lncRNAs in the regulation of resistance to cold, salt, and heat stress and in fruit, root, and leaf development. However, experimental methods are labor-intensive and costly approaches and cannot yet be used for genome-wide mass studies of lncRNAs. For this purpose, bioinformatic approaches that aim at large-scale recognition of lncRNA sequences in genomes and transcriptomes have been applied. However, despite the growing number of studies devoted to the structural and functional analysis of lncRNAs, this type of molecule remains poorly understood. This is due to the many factors that need to be considered when identifying lncRNAs. The use of pan-genomes and pan-transcriptomes will improve the efficiency of the study and the total number of predicted lncRNAs compared to using the genome of a single species representative. This review focuses on describing the molecular and biological functions of lncRNAs and experimental and bioinformatic methods of identification, patterns of evolution, and detection and analysis of lncRNAs at the scale of pan-genomes and pan-transcriptomes.

KW - long noncoding RNAs

KW - microRNAs

KW - pan-genome

KW - transcription regulation

UR - https://www.mendeley.com/catalogue/e230f2e6-67b4-36b5-b4a2-21c453b3b6e4/

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-86000006981&origin=inward&txGid=c3f34ac96432887e8b2e94abf0f4232e

UR - https://www.elibrary.ru/item.asp?id=80381342

U2 - 10.1134/S1022795424701345

DO - 10.1134/S1022795424701345

M3 - Article

VL - 61

SP - 1

EP - 18

JO - Russian Journal of Genetics

JF - Russian Journal of Genetics

SN - 1022-7954

IS - 1

ER -