TY - JOUR

T1 - The role of hydrolysis in biological effects of molybdenum cluster with DMSO ligands

AU - Pronina, Ekaterina V.

AU - Pozmogova, Tatiana N.

AU - Vorotnikov, Yuri A.

AU - Ivanov, Anton A.

AU - Shestopalov, Michael A.

N1 - Funding Information: This research was supported by the Russian Foundation for Basic Research (Grant no. 20-33-90087). The NIIC team thanks the Ministry of Science and Higher Education of the Russian Federation (No. 121031700321-3). Publisher Copyright: © 2021, The Author(s), under exclusive licence to Society for Biological Inorganic Chemistry (SBIC).

PY - 2022/2

Y1 - 2022/2

N2 - Biological applications of octahedral molybdenum cluster complexes are complicated by their hydrolytic instability, since hydrolysis leads to irreversible changes in the structure and properties of these compounds. On the other hand, if such changes are thoroughly investigated and understood, the hydrolysis process can become an important tool for regulating specific biological effects of the clusters. In this work, we demonstrate how the luminescence and biological properties (cellular uptake, cytotoxicity in the dark and photodynamic effect) of highly unstable cluster complex [{Mo6I8}(DMSO)6](NO3)4 change along with the degree of hydrolysis. Particularly, cluster solution preliminarily aged in water demonstrated lower dark and higher photoinduced cytotoxicity and higher cellular uptake in comparison with fresh solution.

AB - Biological applications of octahedral molybdenum cluster complexes are complicated by their hydrolytic instability, since hydrolysis leads to irreversible changes in the structure and properties of these compounds. On the other hand, if such changes are thoroughly investigated and understood, the hydrolysis process can become an important tool for regulating specific biological effects of the clusters. In this work, we demonstrate how the luminescence and biological properties (cellular uptake, cytotoxicity in the dark and photodynamic effect) of highly unstable cluster complex [{Mo6I8}(DMSO)6](NO3)4 change along with the degree of hydrolysis. Particularly, cluster solution preliminarily aged in water demonstrated lower dark and higher photoinduced cytotoxicity and higher cellular uptake in comparison with fresh solution.

KW - Cluster compounds

KW - Cytotoxicity

KW - Hydrolysis

KW - Molybdenum

KW - Photoinduced cytotoxicity

UR - http://www.scopus.com/inward/record.url?scp=85119008613&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/172da743-e568-3e7a-aa23-30ce34c9b5e0/

U2 - 10.1007/s00775-021-01914-3

DO - 10.1007/s00775-021-01914-3

M3 - Article

C2 - 34782931

AN - SCOPUS:85119008613

VL - 27

SP - 111

EP - 119

JO - Journal of Biological Inorganic Chemistry

JF - Journal of Biological Inorganic Chemistry

SN - 0949-8257

IS - 1

ER -